(56 nodes) Negative regulation of osteoblast differentiation network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Id2	DNA-binding protein inhibitor ID-2. (134 aa)
	Hdac8	Histone deacetylase 8 isoform X1. (377 aa)
	Cited1	Cbp/p300-interacting transactivator 1 isoform X1. (203 aa)
	Limd1	LIM domain-containing protein 1. (668 aa)
	Smad6	Mothers against decapentaplegic homolog 6. (496 aa)
	Smad3	Mothers against decapentaplegic homolog 3. (425 aa)
	Hand2	Heart- and neural crest derivatives-expressed protein 2. (217 aa)
	Vegfc	Vascular endothelial growth factor C/D. (415 aa)
	Fgfr1	Fibroblast growth factor receptor 1 isoform X1. (833 aa)
	Sfrp1	Secreted frizzled-related protein 1. (288 aa)
	Trpm4	Transient receptor potential cation channel subfamily M member 4. (1213 aa)
	Fgf23	Fibroblast growth factor 23. (251 aa)
	Pparg	Peroxisome proliferator-activated receptor gamma isoform X1. (505 aa)
	Hoxa2	Homeobox protein HoxA/B2. (372 aa)
	Areg	Amphiregulin. (248 aa)
	Cdk6	Cyclin-dependent kinase 6. (326 aa)
	Ski	Ski oncogene. (727 aa)
	Id3	DNA-binding protein inhibitor ID-3. (119 aa)
	Tmem64	Transmembrane protein 64 isoform X1. (381 aa)
	Noct	Nocturnin isoform X1. (429 aa)
	Sox2	Transcription factor SOX2 (SOX group B). (319 aa)
	Fndc3b	Fibronectin type III domain-containing protein 3B isoform X1. (1207 aa)
	Id1	DNA-binding protein inhibitor ID-1. (164 aa)
	Grem1	Gremlin-1 isoform X1. (184 aa)
	Tnfaip6	Tumor necrosis factor-inducible gene 6 protein. (275 aa)
	Notch1	Neurogenic locus notch homolog protein 1. (2531 aa)
	Ucma	Unique cartilage matrix-associated protein isoform X1. (138 aa)
	Rorb	Nuclear receptor ROR-beta isoform X1. (470 aa)
	Men1	Menin isoform X1. (617 aa)
	Lrp5	Low density lipoprotein receptor-related protein 5/6. (1611 aa)
	Nfatc1	Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (938 aa)
	Bambi	BMP and activin membrane-bound inhibitor homolog. (260 aa)
	Crim1	Cysteine-rich motor neuron 1 protein. (1037 aa)
	Twsg1	Twisted gastrulation protein homolog 1 isoform X1. (222 aa)
	Tnf	Tumor necrosis factor superfamily, member 2. (235 aa)
	Ostn	Osteocrin isoform X1. (130 aa)
	Chrd	Chordin isoform X1. (948 aa)
	Hdac7	Histone deacetylase 7. (975 aa)
	Ranbp3l	Ran-binding protein 3-like. (93 aa)
	Gdf10	Growth differentiation factor 10. (476 aa)
	Ptch1	Protein patched homolog 1. (1434 aa)
	Sema4d	Semaphorin-4D isoform X1. (859 aa)
	Dlk1	Protein delta homolog 1 isoform X1. (385 aa)
	Riox1	Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66. (604 aa)
	Ahr	Aryl hydrocarbon receptor. (854 aa)
	Twist1	Twist-related protein 1. (206 aa)
	Sox9	Transcription factor SOX9 (SOX group E). (507 aa)
	Axin2	Axin 2. (840 aa)
	Hdac5	Histone deacetylase 5 isoform X1. (1119 aa)
	Nbr1	Next to BRCA1 gene 1 protein isoform X1. (988 aa)
	Tob1	Protein Tob/BTG. (356 aa)
	Nog	Noggin. (232 aa)
	Tnn	Tenascin-N. (1560 aa)
	Hdac4	Histone deacetylase 4/5. (1076 aa)
	Twist2	Twist-related protein 2. (160 aa)
	Igfbp5	Insulin-like growth factor-binding protein 5. (271 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Areg	Fgfr1	MGP_CAROLIEiJ_P0069062	MGP_CAROLIEiJ_P0084029	Amphiregulin.	Fibroblast growth factor receptor 1 isoform X1.	0.754
Areg	Tnf	MGP_CAROLIEiJ_P0069062	MGP_CAROLIEiJ_P0044486	Amphiregulin.	Tumor necrosis factor superfamily, member 2.	0.584
Areg	Tnfaip6	MGP_CAROLIEiJ_P0069062	MGP_CAROLIEiJ_P0051745	Amphiregulin.	Tumor necrosis factor-inducible gene 6 protein.	0.435
Axin2	Lrp5	MGP_CAROLIEiJ_P0030674	MGP_CAROLIEiJ_P0047338	Axin 2.	Low density lipoprotein receptor-related protein 5/6.	0.889
Axin2	Notch1	MGP_CAROLIEiJ_P0030674	MGP_CAROLIEiJ_P0050383	Axin 2.	Neurogenic locus notch homolog protein 1.	0.473
Axin2	Sfrp1	MGP_CAROLIEiJ_P0030674	MGP_CAROLIEiJ_P0083978	Axin 2.	Secreted frizzled-related protein 1.	0.685
Axin2	Sox2	MGP_CAROLIEiJ_P0030674	MGP_CAROLIEiJ_P0057315	Axin 2.	Transcription factor SOX2 (SOX group B).	0.402
Axin2	Sox9	MGP_CAROLIEiJ_P0030674	MGP_CAROLIEiJ_P0030751	Axin 2.	Transcription factor SOX9 (SOX group E).	0.566
Axin2	Twist1	MGP_CAROLIEiJ_P0030674	MGP_CAROLIEiJ_P0032133	Axin 2.	Twist-related protein 1.	0.501
Bambi	Chrd	MGP_CAROLIEiJ_P0045926	MGP_CAROLIEiJ_P0041006	BMP and activin membrane-bound inhibitor homolog.	Chordin isoform X1.	0.453
Bambi	Lrp5	MGP_CAROLIEiJ_P0045926	MGP_CAROLIEiJ_P0047338	BMP and activin membrane-bound inhibitor homolog.	Low density lipoprotein receptor-related protein 5/6.	0.910
Bambi	Smad3	MGP_CAROLIEiJ_P0045926	MGP_CAROLIEiJ_P0088272	BMP and activin membrane-bound inhibitor homolog.	Mothers against decapentaplegic homolog 3.	0.604
Bambi	Smad6	MGP_CAROLIEiJ_P0045926	MGP_CAROLIEiJ_P0088277	BMP and activin membrane-bound inhibitor homolog.	Mothers against decapentaplegic homolog 6.	0.729
Cdk6	Notch1	MGP_CAROLIEiJ_P0066476	MGP_CAROLIEiJ_P0050383	Cyclin-dependent kinase 6.	Neurogenic locus notch homolog protein 1.	0.468
Cdk6	Sox2	MGP_CAROLIEiJ_P0066476	MGP_CAROLIEiJ_P0057315	Cyclin-dependent kinase 6.	Transcription factor SOX2 (SOX group B).	0.579
Chrd	Bambi	MGP_CAROLIEiJ_P0041006	MGP_CAROLIEiJ_P0045926	Chordin isoform X1.	BMP and activin membrane-bound inhibitor homolog.	0.453
Chrd	Nog	MGP_CAROLIEiJ_P0041006	MGP_CAROLIEiJ_P0029156	Chordin isoform X1.	Noggin.	0.702
Chrd	Smad6	MGP_CAROLIEiJ_P0041006	MGP_CAROLIEiJ_P0088277	Chordin isoform X1.	Mothers against decapentaplegic homolog 6.	0.530
Chrd	Tnfaip6	MGP_CAROLIEiJ_P0041006	MGP_CAROLIEiJ_P0051745	Chordin isoform X1.	Tumor necrosis factor-inducible gene 6 protein.	0.545
Chrd	Twsg1	MGP_CAROLIEiJ_P0041006	MGP_CAROLIEiJ_P0045478	Chordin isoform X1.	Twisted gastrulation protein homolog 1 isoform X1.	0.787