(18 nodes) Regulation of isotype switching to IgG isotypes network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pagr1	PAXIP1 associated glutamate rich protein 1. (253 aa)
	Cd28	T-cell-specific surface glycoprotein CD28. (219 aa)
	Ptprc	Receptor-type tyrosine-protein phosphatase C. (1302 aa)
	Ifng	Interferon gamma. (155 aa)
	Il4	Interleukin 4. (140 aa)
	Atad5	ATPase family AAA domain-containing protein 5 isoform X1. (1835 aa)
	Tbx21	T-box transcription factor TBX21. (530 aa)
	Msh2	DNA mismatch repair protein MSH2. (936 aa)
	Ndfip1	NEDD4 family-interacting protein 1. (221 aa)
	Cd40	Tumor necrosis factor receptor superfamily member 5 isoform X1. (289 aa)
	Il2	Interleukin 2. (164 aa)
	Paxip1	PAX-interacting protein 1 isoform X1. (1057 aa)
	Slc15a4	Solute carrier family 15 (peptide/histidine transporter), member 3/4. (574 aa)
	Pms2	Mismatch repair endonuclease PMS2. (859 aa)
	Pagr1-2	PAXIP1-associated glutamate-rich protein 1. (253 aa)
	Il27ra	Interleukin-27 receptor subunit alpha. (631 aa)
	Mlh1	DNA mismatch repair protein Mlh1 isoform X1. (760 aa)
	Foxp3	Forkhead box protein P3 isoform X1. (428 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd28	Cd40	MGP_CAROLIEiJ_P0017946	MGP_CAROLIEiJ_P0056161	T-cell-specific surface glycoprotein CD28.	Tumor necrosis factor receptor superfamily member 5 isoform X1.	0.733
Cd28	Foxp3	MGP_CAROLIEiJ_P0017946	MGP_CAROLIEiJ_P0090803	T-cell-specific surface glycoprotein CD28.	Forkhead box protein P3 isoform X1.	0.710
Cd28	Ifng	MGP_CAROLIEiJ_P0017946	MGP_CAROLIEiJ_P0024852	T-cell-specific surface glycoprotein CD28.	Interferon gamma.	0.676
Cd28	Il2	MGP_CAROLIEiJ_P0017946	MGP_CAROLIEiJ_P0057416	T-cell-specific surface glycoprotein CD28.	Interleukin 2.	0.723
Cd28	Il4	MGP_CAROLIEiJ_P0017946	MGP_CAROLIEiJ_P0026641	T-cell-specific surface glycoprotein CD28.	Interleukin 4.	0.608
Cd28	Ptprc	MGP_CAROLIEiJ_P0017946	MGP_CAROLIEiJ_P0020154	T-cell-specific surface glycoprotein CD28.	Receptor-type tyrosine-protein phosphatase C.	0.506
Cd40	Cd28	MGP_CAROLIEiJ_P0056161	MGP_CAROLIEiJ_P0017946	Tumor necrosis factor receptor superfamily member 5 isoform X1.	T-cell-specific surface glycoprotein CD28.	0.733
Cd40	Foxp3	MGP_CAROLIEiJ_P0056161	MGP_CAROLIEiJ_P0090803	Tumor necrosis factor receptor superfamily member 5 isoform X1.	Forkhead box protein P3 isoform X1.	0.807
Cd40	Ifng	MGP_CAROLIEiJ_P0056161	MGP_CAROLIEiJ_P0024852	Tumor necrosis factor receptor superfamily member 5 isoform X1.	Interferon gamma.	0.739
Cd40	Il2	MGP_CAROLIEiJ_P0056161	MGP_CAROLIEiJ_P0057416	Tumor necrosis factor receptor superfamily member 5 isoform X1.	Interleukin 2.	0.787
Cd40	Il4	MGP_CAROLIEiJ_P0056161	MGP_CAROLIEiJ_P0026641	Tumor necrosis factor receptor superfamily member 5 isoform X1.	Interleukin 4.	0.729
Cd40	Ptprc	MGP_CAROLIEiJ_P0056161	MGP_CAROLIEiJ_P0020154	Tumor necrosis factor receptor superfamily member 5 isoform X1.	Receptor-type tyrosine-protein phosphatase C.	0.639
Foxp3	Cd28	MGP_CAROLIEiJ_P0090803	MGP_CAROLIEiJ_P0017946	Forkhead box protein P3 isoform X1.	T-cell-specific surface glycoprotein CD28.	0.710
Foxp3	Cd40	MGP_CAROLIEiJ_P0090803	MGP_CAROLIEiJ_P0056161	Forkhead box protein P3 isoform X1.	Tumor necrosis factor receptor superfamily member 5 isoform X1.	0.807
Foxp3	Ifng	MGP_CAROLIEiJ_P0090803	MGP_CAROLIEiJ_P0024852	Forkhead box protein P3 isoform X1.	Interferon gamma.	0.843
Foxp3	Il2	MGP_CAROLIEiJ_P0090803	MGP_CAROLIEiJ_P0057416	Forkhead box protein P3 isoform X1.	Interleukin 2.	0.940
Foxp3	Il27ra	MGP_CAROLIEiJ_P0090803	MGP_CAROLIEiJ_P0085207	Forkhead box protein P3 isoform X1.	Interleukin-27 receptor subunit alpha.	0.421
Foxp3	Il4	MGP_CAROLIEiJ_P0090803	MGP_CAROLIEiJ_P0026641	Forkhead box protein P3 isoform X1.	Interleukin 4.	0.800
Foxp3	Ptprc	MGP_CAROLIEiJ_P0090803	MGP_CAROLIEiJ_P0020154	Forkhead box protein P3 isoform X1.	Receptor-type tyrosine-protein phosphatase C.	0.728
Foxp3	Tbx21	MGP_CAROLIEiJ_P0090803	MGP_CAROLIEiJ_P0029505	Forkhead box protein P3 isoform X1.	T-box transcription factor TBX21.	0.730