(134 nodes) Negative regulation of inflammatory response network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Uaca	Uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1. (1413 aa)
	Foxp3	Forkhead box protein P3 isoform X1. (428 aa)
	Gpx1	Glutathione peroxidase 1. (145 aa)
	Il20rb	Interleukin-20 receptor subunit beta. (308 aa)
	Nt5e	5'-nucleotidase. (485 aa)
	Rora	Nuclear receptor ROR-alpha isoform X1. (523 aa)
	Smad3	Mothers against decapentaplegic homolog 3. (425 aa)
	Cd276	CD276 antigen. (316 aa)
	Cyp19a1	Aromatase. (503 aa)
	Ets1	Protein C-ets-1. (440 aa)
	Acp5	Tartrate-resistant acid phosphatase type 5. (327 aa)
	Ldlr	Low-density lipoprotein receptor. (861 aa)
	Foxf1	Forkhead box protein F1. (378 aa)
	Wfdc1	WAP four-disulfide core domain protein 1 isoform X1. (211 aa)
	Cdh5	Cadherin 5, type 2, VE-cadherin. (784 aa)
	Cx3cl1	C-X3-C motif chemokine 1. (395 aa)
	Cyld	Ubiquitin carboxyl-terminal hydrolase CYLD. (955 aa)
	Nod2	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1020 aa)
	Vps35	Vacuolar protein sorting-associated protein 35. (796 aa)
	Npy5r	Neuropeptide Y receptor type 5. (466 aa)
	Mfhas1	Malignant fibrous histiocytoma-amplified sequence 1 isoform X1. (1048 aa)
	Nlrp6	NACHT, LRR and PYD domains-containing protein 6. (901 aa)
	Spn	Leukosialin. (386 aa)
	Psma1	Proteasome subunit alpha type-1. (263 aa)
	Selenos	Selenoprotein S isoform X1. (187 aa)
	Chrna7	Neuronal acetylcholine receptor subunit alpha-7. (502 aa)
	Siglece	Sialic acid binding Ig-like lectin 12. (462 aa)
	Siglecg	Sialic acid binding Ig-like lectin G. (597 aa)
	Zfp36	MRNA decay activator protein ZFP36. (319 aa)
	Cxcl17	C-X-C motif chemokine 17. (128 aa)
	Rps19	Small subunit ribosomal protein S19e. (176 aa)
	Apoe	Apolipoprotein E. (312 aa)
	Pglyrp1	Peptidoglycan recognition protein 1. (182 aa)
	Nlrp12	NACHT, LRR and PYD domains-containing protein 12. (1050 aa)
	Tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A. (452 aa)
	Lpcat3	Lysophospholipid acyltransferase 5. (487 aa)
	Alox5	Arachidonate 5-lipoxygenase isoform X1. (674 aa)
	Mkrn2	Probable E3 ubiquitin-protein ligase makorin-2. (416 aa)
	Pparg	Peroxisome proliferator-activated receptor gamma isoform X1. (505 aa)
	Ghrl	Appetite-regulating hormone isoform X1. (117 aa)
	Npy	Pro-neuropeptide Y. (97 aa)
	Gper1	G-protein coupled estrogen receptor 1. (375 aa)
	Rabgef1	Rab5 GDP/GTP exchange factor isoform X1. (491 aa)
	Mvk	Mevalonate kinase. (407 aa)
	Slit2	Slit homolog 2 protein isoform X1. (1542 aa)
	Fndc4	Fibronectin type III domain-containing protein 4. (230 aa)
	Hgf	Hepatocyte growth factor isoform X1. (728 aa)
	C1qtnf12	Adipolin. (308 aa)
	Tnfrsf1b	Tumor necrosis factor receptor superfamily member 1B. (474 aa)
	Pla2g5	Calcium-dependent phospholipase A2. (137 aa)
	Cnr2	Cannabinoid receptor 2. (347 aa)
	Smpdl3b	Acid sphingomyelinase-like phosphodiesterase 3b. (456 aa)
	Nfkb1	Nuclear factor NF-kappa-B p105 subunit. (971 aa)
	Tafa3	Protein FAM19A3. (132 aa)
	Tnfaip8l2	Tumor necrosis factor alpha-induced protein 8-like protein 2. (184 aa)
	Psmb4	Proteasome subunit beta type-4. (264 aa)
	Syt11	Synaptotagmin-11. (430 aa)
	Il2	Interleukin 2. (164 aa)
	Ghsr	Growth hormone secretagogue receptor type 1. (364 aa)
	Ptgis	Prostacyclin synthase. (510 aa)
	Ada	Adenosine deaminase. (352 aa)
	Cst7	Cystatin-F. (144 aa)
	Tyro3	Tyrosine-protein kinase receptor TYRO3. (880 aa)
	Cd44	CD44 antigen isoform X1. (778 aa)
	Mdk	Midkine isoform X1. (140 aa)
	Nr1h3	Oxysterols receptor LXR-alpha isoform X1. (445 aa)
	Calcrl	Calcitonin gene-related peptide type 1 receptor. (463 aa)
	Tnfaip6	Tumor necrosis factor-inducible gene 6 protein. (275 aa)
	Il2ra	Interleukin-2 receptor subunit alpha. (267 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (443 aa)
	Ffar4	Free fatty acid receptor 4. (361 aa)
	Ptpn2	Tyrosine-protein phosphatase non-receptor type 2 isoform X1. (406 aa)
	Adrb2	Adrenergic receptor beta-2. (418 aa)
	Ndfip1	NEDD4 family-interacting protein 1. (221 aa)
	Proc	Vitamin K-dependent protein C isoform X1. (460 aa)
	Gpr17	Uracil nucleotide/cysteinyl leukotriene receptor. (339 aa)
	Adcyap1	Pituitary adenylate cyclase-activating polypeptide isoform X1. (175 aa)
	Socs5	Suppressor of cytokine signaling 5. (536 aa)
	Fem1a	Protein fem-1 homolog A. (388 aa)
	Trem2	Triggering receptor expressed on myeloid cells 2 isoform X1. (249 aa)
	Ier3	Radiation-inducible immediate-early gene IEX-1. (160 aa)
	Tff2	Trefoil factor 2 isoform X1. (129 aa)
	Ppard	Peroxisome proliferator-activated receptor delta. (440 aa)
	Gpr31b	12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor. (319 aa)
	Sod1	Superoxide dismutase, Cu-Zn family. (154 aa)
	Gm609	OX-2 membrane glycoprotein-like isoform X1. (300 aa)
	Cd200	OX-2 membrane glycoprotein. (278 aa)
	Cd200r1	CD200 receptor 1. (305 aa)
	Adipoq	Adiponectin. (247 aa)
	Pla2g10	Group 10 secretory phospholipase A2. (151 aa)
	Nlrc3	LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 3. (1101 aa)
	Mefv	Pyrin isoform X1. (808 aa)
	Krt1	Keratin, type II cytoskeletal 1. (647 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (468 aa)
	Sharpin	Shank-associated RH domain-interacting protein. (376 aa)
	Ccn3	Insulin-like growth factor-binding protein 9. (354 aa)
	Otulin	Ubiquitin thioesterase otulin isoform X1. (352 aa)
	C1qtnf3	Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
	Ptger4	Prostaglandin E2 receptor EP4 subtype isoform X1. (513 aa)
	Acod1	Cis-aconitate decarboxylase. (488 aa)
	Rb1	Retinoblastoma-associated protein. (922 aa)
	Pbk	Lymphokine-activated killer T-cell-originated protein kinase. (330 aa)
	Nr1d2	Nuclear receptor subfamily 1 group D member 2. (575 aa)
	Isl1	Insulin gene enhancer protein ISL-1 isoform X1. (349 aa)
	Aoah	Acyloxyacyl hydrolase isoform X1. (574 aa)
	Gpx2	Glutathione peroxidase 2. (190 aa)
	Lrfn5	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform X1. (746 aa)
	Metrnl	Meteorin-like protein. (311 aa)
	Socs3	Suppressor of cytokine signaling 3. (225 aa)
	Grn	Progranulin. (602 aa)
	Nr1d1	Nuclear receptor subfamily 1 group D member 1. (619 aa)
	Lgals9	Galectin-9 isoform X1. (353 aa)
	Git1	G protein-coupled receptor kinase interactor 1. (770 aa)
	Abr	Active breakpoint cluster region-related protein isoform X1. (871 aa)
	Serpinf1	Pigment epithelium-derived factor. (417 aa)
	Gps2	G protein pathway suppressor 2 isoform X1. (327 aa)
	Nlrp3	NACHT, LRR and PYD domains-containing protein 3. (1033 aa)
	Il13	Interleukin 13. (131 aa)
	Il4	Interleukin 4. (140 aa)
	Il12b	Interleukin-12 subunit beta. (333 aa)
	Nr1h4	Bile acid receptor isoform X1. (488 aa)
	Igf1	Insulin-like growth factor I isoform X1. (165 aa)
	Adora2a	Adenosine receptor A2a. (410 aa)
	Bcr	Breakpoint cluster region protein. (1270 aa)
	Cd24a	Signal transducer CD24. (76 aa)
	Enpp3	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3. (874 aa)
	Il22ra2	Interleukin-22 receptor subunit alpha-2 isoform X1. (230 aa)
	Tnfaip3	Tumor necrosis factor alpha-induced protein 3 isoform X1. (776 aa)
	Dusp10	Dual specificity protein phosphatase 10. (483 aa)
	Slamf8	SLAM family member 8. (278 aa)
	Fcgr2b	Fc receptor, IgG, low affinity IIb. (340 aa)
	Adora1	Adenosine receptor A1. (326 aa)
	Il10	Interleukin 10. (178 aa)
	D1Ertd622e	UNC119-binding protein C5orf30 homolog. (207 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acp5	Enpp3	MGP_CAROLIEiJ_P0087025	MGP_CAROLIEiJ_P0022508	Tartrate-resistant acid phosphatase type 5.	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3.	0.904
Ada	Adora1	MGP_CAROLIEiJ_P0055990	MGP_CAROLIEiJ_P0019940	Adenosine deaminase.	Adenosine receptor A1.	0.590
Ada	Adora2a	MGP_CAROLIEiJ_P0055990	MGP_CAROLIEiJ_P0023404	Adenosine deaminase.	Adenosine receptor A2a.	0.668
Ada	Il2	MGP_CAROLIEiJ_P0055990	MGP_CAROLIEiJ_P0057416	Adenosine deaminase.	Interleukin 2.	0.539
Ada	Nt5e	MGP_CAROLIEiJ_P0055990	MGP_CAROLIEiJ_P0088987	Adenosine deaminase.	5'-nucleotidase.	0.970
Adcyap1	Adora2a	MGP_CAROLIEiJ_P0045879	MGP_CAROLIEiJ_P0023404	Pituitary adenylate cyclase-activating polypeptide isoform X1.	Adenosine receptor A2a.	0.930
Adcyap1	Calcrl	MGP_CAROLIEiJ_P0045879	MGP_CAROLIEiJ_P0052580	Pituitary adenylate cyclase-activating polypeptide isoform X1.	Calcitonin gene-related peptide type 1 receptor.	0.634
Adcyap1	Npy	MGP_CAROLIEiJ_P0045879	MGP_CAROLIEiJ_P0073773	Pituitary adenylate cyclase-activating polypeptide isoform X1.	Pro-neuropeptide Y.	0.577
Adipoq	Apoe	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0077810	Adiponectin.	Apolipoprotein E.	0.656
Adipoq	Ghrl	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0075490	Adiponectin.	Appetite-regulating hormone isoform X1.	0.666
Adipoq	Gpx1	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0089925	Adiponectin.	Glutathione peroxidase 1.	0.533
Adipoq	Gpx2	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0032604	Adiponectin.	Glutathione peroxidase 2.	0.471
Adipoq	Igf1	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0024389	Adiponectin.	Insulin-like growth factor I isoform X1.	0.601
Adipoq	Il10	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0019708	Adiponectin.	Interleukin 10.	0.672
Adipoq	Il4	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0026641	Adiponectin.	Interleukin 4.	0.461
Adipoq	Npy	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0073773	Adiponectin.	Pro-neuropeptide Y.	0.501
Adipoq	Nr1h3	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0053038	Adiponectin.	Oxysterols receptor LXR-alpha isoform X1.	0.428
Adipoq	Nr1h4	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0024457	Adiponectin.	Bile acid receptor isoform X1.	0.427
Adipoq	Ppara	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0039338	Adiponectin.	Peroxisome proliferator-activated receptor alpha.	0.726
Adipoq	Ppard	MGP_CAROLIEiJ_P0041092	MGP_CAROLIEiJ_P0043608	Adiponectin.	Peroxisome proliferator-activated receptor delta.	0.563