(48 nodes) Lung epithelium development network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Grhl2	Transcription factor CP2 and related proteins. (625 aa)
	Creb1	cAMP responsive element binding protein 1. (341 aa)
	Map2k2	Dual specificity mitogen-activated protein kinase kinase 2 isoform X1. (401 aa)
	Ascl1	Achaete-scute complex protein. (231 aa)
	Igf1	Insulin-like growth factor I isoform X1. (165 aa)
	Lta4h	Leukotriene A-4 hydrolase isoform X1. (611 aa)
	Ppp3r1	Serine/threonine-protein phosphatase 2B regulatory subunit. (170 aa)
	Thra	Thyroid hormone receptor alpha. (492 aa)
	Sox9	Transcription factor SOX9 (SOX group E). (507 aa)
	Foxj1	Forkhead box protein J1. (421 aa)
	Agr2	Anterior gradient protein 2 homolog. (175 aa)
	Nkx2-1	Homeobox protein Nkx-2.1 isoform X1. (372 aa)
	Foxa1	Forkhead box protein A1, hepatocyte nuclear factor 3-alpha. (468 aa)
	Sav1	Protein salvador homolog 1. (386 aa)
	Fgfr4	Fibroblast growth factor receptor 4 isoform X1. (799 aa)
	Fgf10	Fibroblast growth factor 10. (209 aa)
	Thrb	Thyroid hormone receptor beta isoform X1. (475 aa)
	Bmp4	Bone morphogenetic protein 4. (408 aa)
	Wnt7b	Wingless-type MMTV integration site family, member 7. (353 aa)
	Pkd1	Polycystin-1 isoform X1. (4293 aa)
	Spdef	SAM pointed domain-containing Ets transcription factor isoform X1. (325 aa)
	Foxp4	Forkhead box protein P4 isoform X1. (685 aa)
	Gata6	Transcription factor GATA-6. (589 aa)
	Adamtsl2	ADAMTS-like protein 2. (958 aa)
	Rbbp9	Putative hydrolase RBBP9. (186 aa)
	Foxa2	Forkhead box protein A2, hepatocyte nuclear factor 3-beta. (465 aa)
	Fndc3b	Fibronectin type III domain-containing protein 3B isoform X1. (1207 aa)
	Tmem38b	Trimeric intracellular cation channel type B. (292 aa)
	Nfib	Nuclear factor 1 B-type isoform X1. (570 aa)
	Errfi1	ERBB receptor feedback inhibitor 1. (461 aa)
	Shh	Sonic hedgehog protein isoform X1. (438 aa)
	Fgfr3	Fibroblast growth factor receptor 3. (802 aa)
	Rbpj	Recombining binding protein suppressor of hairless. (180 aa)
	Ncor2	Nuclear receptor corepressor 2 isoform X1. (2507 aa)
	Aimp2	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1. (320 aa)
	Foxp2	Forkhead box protein P2 isoform X1. (739 aa)
	Wnt2	Wingless-type MMTV integration site family, member 2. (360 aa)
	Hoxa5	Homeobox protein HoxA/B/C5. (270 aa)
	Foxp1	Forkhead box protein P1. (715 aa)
	Kras	GTPase KRas isoform X1. (189 aa)
	Rcn3	Reticulocalbin-3. (328 aa)
	Numa1	Nuclear mitotic apparatus protein 1 isoform X1. (2092 aa)
	Dhcr7	7-dehydrocholesterol reductase. (520 aa)
	Klf2	Krueppel-like factor 2. (354 aa)
	Yap1	Transcriptional coactivator YAP1 isoform X1. (488 aa)
	Stra6	Vitamin A receptor/transporter (stra6) family protein. (629 aa)
	Map2k1	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1. (393 aa)
	Ctnnb1	Catenin beta 1. (781 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Agr2	Foxa1	MGP_CAROLIEiJ_P0032146	MGP_CAROLIEiJ_P0032323	Anterior gradient protein 2 homolog.	Forkhead box protein A1, hepatocyte nuclear factor 3-alpha.	0.465
Agr2	Spdef	MGP_CAROLIEiJ_P0032146	MGP_CAROLIEiJ_P0043565	Anterior gradient protein 2 homolog.	SAM pointed domain-containing Ets transcription factor isoform X1.	0.601
Ascl1	Creb1	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0018019	Achaete-scute complex protein.	cAMP responsive element binding protein 1.	0.869
Ascl1	Foxa1	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0032323	Achaete-scute complex protein.	Forkhead box protein A1, hepatocyte nuclear factor 3-alpha.	0.501
Ascl1	Foxa2	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0055070	Achaete-scute complex protein.	Forkhead box protein A2, hepatocyte nuclear factor 3-beta.	0.644
Ascl1	Nfib	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0062765	Achaete-scute complex protein.	Nuclear factor 1 B-type isoform X1.	0.406
Ascl1	Nkx2-1	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0032303	Achaete-scute complex protein.	Homeobox protein Nkx-2.1 isoform X1.	0.577
Ascl1	Rbpj	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0068205	Achaete-scute complex protein.	Recombining binding protein suppressor of hairless.	0.424
Ascl1	Shh	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0067069	Achaete-scute complex protein.	Sonic hedgehog protein isoform X1.	0.582
Ascl1	Sox9	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0030751	Achaete-scute complex protein.	Transcription factor SOX9 (SOX group E).	0.404
Ascl1	Wnt2	MGP_CAROLIEiJ_P0024379	MGP_CAROLIEiJ_P0072724	Achaete-scute complex protein.	Wingless-type MMTV integration site family, member 2.	0.429
Bmp4	Ctnnb1	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0090603	Bone morphogenetic protein 4.	Catenin beta 1.	0.613
Bmp4	Fgf10	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0035544	Bone morphogenetic protein 4.	Fibroblast growth factor 10.	0.715
Bmp4	Foxa2	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0055070	Bone morphogenetic protein 4.	Forkhead box protein A2, hepatocyte nuclear factor 3-beta.	0.559
Bmp4	Gata6	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0046040	Bone morphogenetic protein 4.	Transcription factor GATA-6.	0.578
Bmp4	Igf1	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0024389	Bone morphogenetic protein 4.	Insulin-like growth factor I isoform X1.	0.538
Bmp4	Nkx2-1	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0032303	Bone morphogenetic protein 4.	Homeobox protein Nkx-2.1 isoform X1.	0.451
Bmp4	Shh	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0067069	Bone morphogenetic protein 4.	Sonic hedgehog protein isoform X1.	0.690
Bmp4	Sox9	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0030751	Bone morphogenetic protein 4.	Transcription factor SOX9 (SOX group E).	0.582
Bmp4	Wnt2	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0072724	Bone morphogenetic protein 4.	Wingless-type MMTV integration site family, member 2.	0.686