(137 nodes) Negative regulation of canonical Wnt signaling pathway network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Scyl2	SCY1-like protein 2 isoform X1. (930 aa)
	Gli1	Zinc finger protein GLI1. (1112 aa)
	Kremen1	Kremen protein 1. (473 aa)
	Znrf3	E3 ubiquitin-protein ligase ZNRF3 isoform X1. (913 aa)
	Shisa6	Shisa family member 6. (524 aa)
	Tmem88	Transmembrane protein 88. (159 aa)
	Nog	Noggin. (232 aa)
	MGP_CAROLIEiJ_P0029672	annotation not available (412 aa)
	Sost	Sclerostin. (211 aa)
	Amer1	APC membrane recruitment protein 1 isoform X1. (1139 aa)
	Emd	Emerin. (259 aa)
	Gpc3	Glypican-3 isoform X1. (579 aa)
	Otud5	OTU domain-containing protein 5 isoform X1. (571 aa)
	Limd1	LIM domain-containing protein 1. (668 aa)
	Ctnnb1	Catenin beta 1. (781 aa)
	Rbms3	RNA-binding motif, single-stranded-interacting protein 3 isoform X1. (463 aa)
	Nphp3	Nephrocystin-3. (1325 aa)
	Tbx18	T-box18. (522 aa)
	Tpbg	Trophoblast glycoprotein. (426 aa)
	Tle3	Transducin-like enhancer protein 3 isoform X1. (783 aa)
	MGP_CAROLIEiJ_P0086001	annotation not available (311 aa)
	Cdh1	Cadherin 1, type 1, E-cadherin. (884 aa)
	Amfr	E3 ubiquitin-protein ligase AMFR isoform X1. (643 aa)
	Cyld	Ubiquitin carboxyl-terminal hydrolase CYLD. (955 aa)
	Nkd1	Protein naked cuticle homolog 1 isoform X1. (471 aa)
	Sfrp1	Secreted frizzled-related protein 1. (288 aa)
	Dkk4	Dickkopf WNT signaling pathway inhibitor 4. (170 aa)
	Dkk3	Dickkopf-related protein 3 isoform X1. (349 aa)
	Tpbgl	Trophoblast glycoprotein-like. (384 aa)
	Wnt11	Wingless-type MMTV integration site family, member 11. (354 aa)
	Fzd4	Frizzled 4. (537 aa)
	Mesp1	Mesoderm posterior protein 1. (244 aa)
	Ruvbl2	RuvB-like protein 2. (463 aa)
	Dkkl1	Dickkopf-like protein 1. (230 aa)
	Fuz	Protein fuzzy homolog isoform X1. (415 aa)
	Gsk3a	Glycogen synthase kinase 3 alpha. (489 aa)
	Apoe	Apolipoprotein E. (312 aa)
	Dact3	Dapper homolog 3. (610 aa)
	Ptpro	Receptor-type tyrosine-protein phosphatase O isoform X1. (1226 aa)
	Wnt5b	Wingless-type MMTV integration site family, member 5. (259 aa)
	Cav1	Caveolin 1. (178 aa)
	Shisa3	Protein shisa-3 homolog. (238 aa)
	Shh	Sonic hedgehog protein isoform X1. (438 aa)
	Fzd1	Frizzled 1/7. (642 aa)
	Nphp4	Nephrocystin-4. (1425 aa)
	Ctnnbip1	Beta-catenin-interacting protein 1 (inhibitor of beta-catenin and Tcf-4). (81 aa)
	Mad2l2	Mitotic spindle assembly checkpoint protein MAD2B. (178 aa)
	Draxin	Draxin isoform X1. (343 aa)
	Nppa	Natriuretic peptides A. (152 aa)
	Ptpru	Receptor-type tyrosine-protein phosphatase U isoform X1. (1446 aa)
	Hdac1	Histone deacetylase 1/2. (482 aa)
	Mllt3	YEATS domain-containing protein 1/3. (569 aa)
	Tle1	TLE family member 1, transcriptional corepressor. (780 aa)
	Invs	Inversin. (1056 aa)
	Ankrd6	Ankyrin repeat domain 6. (677 aa)
	Tmem64	Transmembrane protein 64 isoform X1. (381 aa)
	Dkk2	Dickkopf-related protein 2. (259 aa)
	Tmem131l	Transmembrane protein 131-like isoform X1. (1597 aa)
	Sfrp2	Secreted frizzled-related protein 2. (295 aa)
	Siah2	E3 ubiquitin-protein ligase SIAH2. (325 aa)
	Wwtr1	WW domain-containing transcription regulator protein 1 isoform X1. (452 aa)
	Foxo1	Forkhead box protein O1. (650 aa)
	Jade1	Protein Jade-1. (834 aa)
	Sox2	Transcription factor SOX2 (SOX group B). (319 aa)
	Stk4	Serine/threonine-protein kinase 4. (487 aa)
	Bmp2	Bone morphogenetic protein 2. (394 aa)
	Fermt1	Fermitin family homolog 1 isoform X1. (677 aa)
	Grem1	Gremlin-1 isoform X1. (184 aa)
	Mdk	Midkine isoform X1. (140 aa)
	Lrp4	Low-density lipoprotein receptor-related protein 4. (1905 aa)
	Ctnnd1	Catenin (cadherin-associated protein), delta 1. (905 aa)
	MGP_CAROLIEiJ_P0052606	annotation not available (897 aa)
	Frzb	Secreted frizzled-related protein 3. (323 aa)
	Dab2ip	Disabled homolog 2-interacting protein isoform X1. (1191 aa)
	Rapgef1	Rap guanine nucleotide exchange factor 1 isoform X1. (1223 aa)
	Notch1	Neurogenic locus notch homolog protein 1. (2531 aa)
	Tcf7l2	Transcription factor 7 like 2. (606 aa)
	Lzts2	Leucine zipper putative tumor suppressor 2. (670 aa)
	Sfrp5	Secreted frizzled-related protein 5. (314 aa)
	Dkk1	Dickkopf-related protein 1. (272 aa)
	Tle4	Transducin-like enhancer protein 4 isoform X1. (773 aa)
	Sdhaf2	Succinate dehydrogenase assembly factor 2, mitochondrial. (164 aa)
	Frmd8	FERM domain-containing protein 8. (466 aa)
	Csnk1a1	Casein kinase I isoform X1. (365 aa)
	Mcc	Colorectal mutant cancer protein isoform X1. (1003 aa)
	Egr1	Early growth response protein 1. (533 aa)
	Apc	Adenomatosis polyposis coli protein. (2841 aa)
	Cdh2	Cadherin 2, type 1, N-cadherin. (906 aa)
	Mapk14	Mitogen-activated protein kinase 14 isoform X1. (360 aa)
	Nkx2-5	Homeobox protein Nkx-2.5. (318 aa)
	Axin1	Axin-1 isoform X1. (868 aa)
	Prkn	E3 ubiquitin-protein ligase parkin isoform X1. (464 aa)
	App	Amyloid beta precursor protein. (695 aa)
	Gsk3b	Glycogen synthase kinase 3 beta. (433 aa)
	Snai2	Zinc finger protein SNAI2. (269 aa)
	Pfdn5	Prefoldin alpha subunit. (154 aa)
	Lmbr1l	LOW QUALITY PROTEIN: protein LMBR1L. (481 aa)
	Prickle1	Prickle-like protein 1. (831 aa)
	Cby1	Protein chibby homolog 1. (127 aa)
	Sox10	Transcription factor SOX7/8/10/18 (SOX group E/F). (466 aa)
	Cthrc1	Collagen triple helix repeat-containing protein 1. (245 aa)
	Fzd6	Frizzled 6. (709 aa)
	Stk3	Serine/threonine-protein kinase 3. (497 aa)
	Dab2	Disabled homolog 2. (766 aa)
	Ubac2	Ubiquitin-associated domain-containing protein 2 isoform X1. (345 aa)
	Amer2	APC membrane recruitment protein 2 isoform X1. (634 aa)
	Lats2	Serine/threonine-protein kinase LATS1/2. (1042 aa)
	Chd8	Chromodomain-helicase-DNA-binding protein 8 isoform X1. (2318 aa)
	Wnt5a	Wingless-type MMTV integration site family, member 5. (380 aa)
	Isl1	Insulin gene enhancer protein ISL-1 isoform X1. (349 aa)
	Nkd2	Protein naked cuticle homolog 2 isoform X1. (461 aa)
	Ror2	Tyrosine-protein kinase transmembrane receptor ROR2. (943 aa)
	Tmem170b	Transmembrane protein 170B. (132 aa)
	Sfrp4	Secreted frizzled-related protein 4. (348 aa)
	Gli3	Transcriptional activator GLI3. (1583 aa)
	Ccdc88c	Protein Daple. (2015 aa)
	MGP_CAROLIEiJ_P0032621	annotation not available (299 aa)
	Dact1	Dapper homolog 1 isoform X1. (815 aa)
	Sostdc1	Sclerostin domain-containing protein 1. (206 aa)
	Notum	Palmitoleoyl-protein carboxylesterase NOTUM. (503 aa)
	Slc9a3r1	Sodium/hydrogen exchange regulatory cofactor NHE-RF1. (355 aa)
	Sox9	Transcription factor SOX9 (SOX group E). (507 aa)
	Axin2	Axin 2. (840 aa)
	Sox17	Transcription factor SOX17 (SOX group F). (419 aa)
	Igfbp2	Insulin-like growth factor-binding protein 2. (305 aa)
	Sox13	Transcription factor SOX5/6/13 (SOX group D). (613 aa)
	Tnn	Tenascin-N. (1560 aa)
	Lats1	Serine/threonine-protein kinase LATS1/2. (1130 aa)
	Hdac2	Histone deacetylase 1/2. (488 aa)
	Foxo3	Forkhead box protein O3. (672 aa)
	Bicc1	Protein bicaudal C homolog 1 isoform X1. (977 aa)
	Stk11	Serine/threonine-protein kinase STK11 isoform X1. (441 aa)
	Apc2	Adenomatous polyposis coli protein 2 isoform X1. (2301 aa)
	Tle5	Amino-terminal enhancer of split isoform X1. (197 aa)
	Tle2	Transducin-like enhancer protein 2 isoform X1. (767 aa)
	Tle6	LOW QUALITY PROTEIN: transducin-like enhancer protein 6. (140 aa)
	Ddit3	DNA damage-inducible transcript 3 protein. (168 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Amer1	Apc	MGP_CAROLIEiJ_P0092163	MGP_CAROLIEiJ_P0046254	APC membrane recruitment protein 1 isoform X1.	Adenomatosis polyposis coli protein.	0.982
Amer1	Apc2	MGP_CAROLIEiJ_P0092163	MGP_CAROLIEiJ_P0023909	APC membrane recruitment protein 1 isoform X1.	Adenomatous polyposis coli protein 2 isoform X1.	0.826
Amer1	Axin1	MGP_CAROLIEiJ_P0092163	MGP_CAROLIEiJ_P0043428	APC membrane recruitment protein 1 isoform X1.	Axin-1 isoform X1.	0.980
Amer1	Axin2	MGP_CAROLIEiJ_P0092163	MGP_CAROLIEiJ_P0030674	APC membrane recruitment protein 1 isoform X1.	Axin 2.	0.841
Amer1	Csnk1a1	MGP_CAROLIEiJ_P0092163	MGP_CAROLIEiJ_P0046871	APC membrane recruitment protein 1 isoform X1.	Casein kinase I isoform X1.	0.910
Amer1	Ctnnb1	MGP_CAROLIEiJ_P0092163	MGP_CAROLIEiJ_P0090603	APC membrane recruitment protein 1 isoform X1.	Catenin beta 1.	0.980
Amer1	Gsk3a	MGP_CAROLIEiJ_P0092163	MGP_CAROLIEiJ_P0078025	APC membrane recruitment protein 1 isoform X1.	Glycogen synthase kinase 3 alpha.	0.658
Amer1	Gsk3b	MGP_CAROLIEiJ_P0092163	MGP_CAROLIEiJ_P0041562	APC membrane recruitment protein 1 isoform X1.	Glycogen synthase kinase 3 beta.	0.975
Amfr	Ubac2	MGP_CAROLIEiJ_P0085559	MGP_CAROLIEiJ_P0037658	E3 ubiquitin-protein ligase AMFR isoform X1.	Ubiquitin-associated domain-containing protein 2 isoform X1.	0.777
Ankrd6	App	MGP_CAROLIEiJ_P0061672	MGP_CAROLIEiJ_P0042114	Ankyrin repeat domain 6.	Amyloid beta precursor protein.	0.535
Ankrd6	Axin1	MGP_CAROLIEiJ_P0061672	MGP_CAROLIEiJ_P0043428	Ankyrin repeat domain 6.	Axin-1 isoform X1.	0.831
Ankrd6	Axin2	MGP_CAROLIEiJ_P0061672	MGP_CAROLIEiJ_P0030674	Ankyrin repeat domain 6.	Axin 2.	0.409
Ankrd6	Ctnnb1	MGP_CAROLIEiJ_P0061672	MGP_CAROLIEiJ_P0090603	Ankyrin repeat domain 6.	Catenin beta 1.	0.418
Ankrd6	Gsk3b	MGP_CAROLIEiJ_P0061672	MGP_CAROLIEiJ_P0041562	Ankyrin repeat domain 6.	Glycogen synthase kinase 3 beta.	0.675
Ankrd6	Prickle1	MGP_CAROLIEiJ_P0061672	MGP_CAROLIEiJ_P0039566	Ankyrin repeat domain 6.	Prickle-like protein 1.	0.757
Apc	Amer1	MGP_CAROLIEiJ_P0046254	MGP_CAROLIEiJ_P0092163	Adenomatosis polyposis coli protein.	APC membrane recruitment protein 1 isoform X1.	0.982
Apc	Apc2	MGP_CAROLIEiJ_P0046254	MGP_CAROLIEiJ_P0023909	Adenomatosis polyposis coli protein.	Adenomatous polyposis coli protein 2 isoform X1.	0.976
Apc	Axin1	MGP_CAROLIEiJ_P0046254	MGP_CAROLIEiJ_P0043428	Adenomatosis polyposis coli protein.	Axin-1 isoform X1.	0.999
Apc	Axin2	MGP_CAROLIEiJ_P0046254	MGP_CAROLIEiJ_P0030674	Adenomatosis polyposis coli protein.	Axin 2.	0.995
Apc	Cdh1	MGP_CAROLIEiJ_P0046254	MGP_CAROLIEiJ_P0085902	Adenomatosis polyposis coli protein.	Cadherin 1, type 1, E-cadherin.	0.872