(12 nodes) Relaxin receptors, and Deubiquitinating enzyme MINDY-3/4 network (Mus musculus)

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Your Input:
	Insl3	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). (122 aa)
	Rln1	Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. (185 aa)
	Rlf	Rearranged L-myc fusion sequence. (1918 aa)
	Rln3	Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. (141 aa)
	Insl6	Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. (191 aa)
	Rxfp4	Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity). (414 aa)
	Rxfp3	Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity); Belongs to the G-protein coupled receptor 1 family. (472 aa)
	Rxfp2	Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family. (737 aa)
	Rxfp1	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. (758 aa)
	Pnmal2	PNMA-like 2. (661 aa)
	Insl5	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. (145 aa)
	Mindy4b-ps	MINDY lysine 48 deubiquitinase 4B, pseudogene. (457 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Insl3	Insl5	ENSMUSP00000034261	ENSMUSP00000102482	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	0.968
Insl3	Insl6	ENSMUSP00000034261	ENSMUSP00000054488	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family.	0.700
Insl3	Rln1	ENSMUSP00000034261	ENSMUSP00000043376	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.	0.977
Insl3	Rln3	ENSMUSP00000034261	ENSMUSP00000051392	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family.	0.974
Insl3	Rxfp1	ENSMUSP00000034261	ENSMUSP00000077611	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.	0.995
Insl3	Rxfp2	ENSMUSP00000034261	ENSMUSP00000067897	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family.	0.999
Insl3	Rxfp3	ENSMUSP00000034261	ENSMUSP00000062741	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity); Belongs to the G-protein coupled receptor 1 family.	0.977
Insl3	Rxfp4	ENSMUSP00000034261	ENSMUSP00000058732	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity).	0.970
Insl5	Insl3	ENSMUSP00000102482	ENSMUSP00000034261	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	0.968
Insl5	Insl6	ENSMUSP00000102482	ENSMUSP00000054488	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family.	0.751
Insl5	Rln1	ENSMUSP00000102482	ENSMUSP00000043376	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.	0.955
Insl5	Rln3	ENSMUSP00000102482	ENSMUSP00000051392	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family.	0.919
Insl5	Rxfp1	ENSMUSP00000102482	ENSMUSP00000077611	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.	0.963
Insl5	Rxfp2	ENSMUSP00000102482	ENSMUSP00000067897	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family.	0.960
Insl5	Rxfp3	ENSMUSP00000102482	ENSMUSP00000062741	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity); Belongs to the G-protein coupled receptor 1 family.	0.968
Insl5	Rxfp4	ENSMUSP00000102482	ENSMUSP00000058732	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity).	0.990
Insl6	Insl3	ENSMUSP00000054488	ENSMUSP00000034261	Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family.	Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).	0.700
Insl6	Insl5	ENSMUSP00000054488	ENSMUSP00000102482	Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family.	Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family.	0.751
Insl6	Rln1	ENSMUSP00000054488	ENSMUSP00000043376	Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family.	Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.	0.713
Insl6	Rln3	ENSMUSP00000054488	ENSMUSP00000051392	Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family.	Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family.	0.762