node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankrd13d | Fam220a | ENSMUSP00000053783 | ENSMUSP00000126480 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). | Protein FAM220A; May negatively regulate STAT3. | 0.547 |
Ankrd13d | Fam220a-2 | ENSMUSP00000053783 | ENSMUSP00000143202 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). | Family with sequence similarity 220, member A. | 0.661 |
Ankrd13d | Fam222a | ENSMUSP00000053783 | ENSMUSP00000045724 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). | Protein FAM222A; Belongs to the FAM222 family. | 0.701 |
Ankrd13d | Ttbk1 | ENSMUSP00000053783 | ENSMUSP00000044580 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). | Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity); Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. | 0.434 |
Fam220a | Ankrd13d | ENSMUSP00000126480 | ENSMUSP00000053783 | Protein FAM220A; May negatively regulate STAT3. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). | 0.547 |
Fam220a | Fam222a | ENSMUSP00000126480 | ENSMUSP00000045724 | Protein FAM220A; May negatively regulate STAT3. | Protein FAM222A; Belongs to the FAM222 family. | 0.503 |
Fam220a-2 | Ankrd13d | ENSMUSP00000143202 | ENSMUSP00000053783 | Family with sequence similarity 220, member A. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). | 0.661 |
Fam220a-2 | Fam222a | ENSMUSP00000143202 | ENSMUSP00000045724 | Family with sequence similarity 220, member A. | Protein FAM222A; Belongs to the FAM222 family. | 0.632 |
Fam220a-2 | Pbxip1 | ENSMUSP00000143202 | ENSMUSP00000040429 | Family with sequence similarity 220, member A. | Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity). | 0.412 |
Fam220a-2 | Urgcp | ENSMUSP00000143202 | ENSMUSP00000091053 | Family with sequence similarity 220, member A. | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. | 0.489 |
Fam222a | Ankrd13d | ENSMUSP00000045724 | ENSMUSP00000053783 | Protein FAM222A; Belongs to the FAM222 family. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). | 0.701 |
Fam222a | Fam220a | ENSMUSP00000045724 | ENSMUSP00000126480 | Protein FAM222A; Belongs to the FAM222 family. | Protein FAM220A; May negatively regulate STAT3. | 0.503 |
Fam222a | Fam220a-2 | ENSMUSP00000045724 | ENSMUSP00000143202 | Protein FAM222A; Belongs to the FAM222 family. | Family with sequence similarity 220, member A. | 0.632 |
Fam222a | Ttbk1 | ENSMUSP00000045724 | ENSMUSP00000044580 | Protein FAM222A; Belongs to the FAM222 family. | Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity); Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. | 0.407 |
Pbxip1 | Fam220a-2 | ENSMUSP00000040429 | ENSMUSP00000143202 | Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity). | Family with sequence similarity 220, member A. | 0.412 |
Pbxip1 | Urgcp | ENSMUSP00000040429 | ENSMUSP00000091053 | Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity). | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. | 0.452 |
Ttbk1 | Ankrd13d | ENSMUSP00000044580 | ENSMUSP00000053783 | Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity); Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). | 0.434 |
Ttbk1 | Fam222a | ENSMUSP00000044580 | ENSMUSP00000045724 | Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity); Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. | Protein FAM222A; Belongs to the FAM222 family. | 0.407 |
Urgcp | Fam220a-2 | ENSMUSP00000091053 | ENSMUSP00000143202 | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. | Family with sequence similarity 220, member A. | 0.489 |
Urgcp | Pbxip1 | ENSMUSP00000091053 | ENSMUSP00000040429 | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. | Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity). | 0.452 |