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Mrpl10 Mrpl10 Mrpl2 Mrpl2 Mrpl4 Mrpl4 Mrpl49 Mrpl49 Mrpl52 Mrpl52 Mrps18c Mrps18c Mrpl45 Mrpl45 Mrpl22 Mrpl22 Mrpl36 Mrpl36 Mrps30 Mrps30 Mrpl57 Mrpl57 Mrpl40 Mrpl40 Mrps23 Mrps23 Mrpl14 Mrpl14 Mrps18a Mrps18a Mrpl28 Mrpl28 Mrpl27 Mrpl27 Mrps18b Mrps18b Mrpl21 Mrpl21 Mrpl11 Mrpl11 Mrpl30 Mrpl30 Mrpl44 Mrpl44 Mrrf Mrrf Mrps5 Mrps5 Mrpl9 Mrpl9 Mrpl37 Mrpl37 Mrps15 Mrps15 Mrpl20 Mrpl20 Mrpl33 Mrpl33 Mrps33 Mrps33 Mrpl19 Mrpl19 Mrpl51 Mrpl51 Mrps11 Mrps11 Mrpl46 Mrpl46 Mrps31 Mrps31 Mrps22 Mrps22 Mrpl3 Mrpl3 Mrps2 Mrps2 Mrps6 Mrps6 Gadd45gip1 Gadd45gip1 Mrps28 Mrps28 Mrpl23 Mrpl23 Mrpl54 Mrpl54 Tsfm Tsfm Ppp1r26 Ppp1r26 Mrpl41 Mrpl41 Mrpl12 Mrpl12 Mrpl34 Mrpl34 Mrps34 Mrps34 Mrpl47 Mrpl47 Mrps35 Mrps35 Mrps7 Mrps7 Mrps16 Mrps16 Mrps9 Mrps9 Mrps27 Mrps27 Mrpl50 Mrpl50 Mrpl35 Mrpl35 Mrps21 Mrps21 Chchd1 Chchd1 Mrpl42 Mrpl42 Gfm1 Gfm1 Mrpl18 Mrpl18 Ptcd3 Ptcd3 Rpl5 Rpl5 Aurkaip1 Aurkaip1 Dap3 Dap3 Mrpl43 Mrpl43 Tufm Tufm Ccdc105 Ccdc105 Mrpl55 Mrpl55 Mrps36 Mrps36 Mrpl53 Mrpl53 Mrpl39 Mrpl39 Mrps17 Mrps17 Mrpl1 Mrpl1 Mrps10 Mrps10 Mrpl24 Mrpl24 Mrps25 Mrps25 Mrpl15 Mrpl15 Mrpl48 Mrpl48 Mrpl58 Mrpl58 Mrpl17 Mrpl17 Mrps24 Mrps24 Mrps14 Mrps14 Mrps26 Mrps26 Gm10260 Gm10260 Mrpl16 Mrpl16 Mrpl13 Mrpl13 Mrps12 Mrps12 Spdye4c Spdye4c Mrpl32 Mrpl32 Gm49711 Gm49711
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mrpl1039S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family. (262 aa)
Mrpl239S ribosomal protein L2, mitochondrial; Belongs to the universal ribosomal protein uL2 family. (306 aa)
Mrpl439S ribosomal protein L4, mitochondrial; Belongs to the universal ribosomal protein uL4 family. (294 aa)
Mrpl4939S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family. (166 aa)
Mrpl5239S ribosomal protein L52, mitochondrial. (121 aa)
Mrps18c28S ribosomal protein S18c, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family. (143 aa)
Mrpl4539S ribosomal protein L45, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL45 family. (306 aa)
Mrpl2239S ribosomal protein L22, mitochondrial; Belongs to the universal ribosomal protein uL22 family. (206 aa)
Mrpl3639S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. (102 aa)
Mrps3028S ribosomal protein S30, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL65 family. (442 aa)
Mrpl57Ribosomal protein 63, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL63 family. (102 aa)
Mrpl4039S ribosomal protein L40, mitochondrial. (206 aa)
Mrps2328S ribosomal protein S23, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS23 family. (177 aa)
Mrpl1439S ribosomal protein L14, mitochondrial; May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation. (145 aa)
Mrps18a28S ribosomal protein S18a, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily. (196 aa)
Mrpl2839S ribosomal protein L28, mitochondrial; Belongs to the bacterial ribosomal protein bL28 family. (257 aa)
Mrpl2739S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. (148 aa)
Mrps18b28S ribosomal protein S18b, mitochondrial. (254 aa)
Mrpl2139S ribosomal protein L21, mitochondrial. (216 aa)
Mrpl1139S ribosomal protein L11, mitochondrial; Belongs to the universal ribosomal protein uL11 family. (192 aa)
Mrpl3039S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family. (160 aa)
Mrpl4439S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily. (333 aa)
MrrfRibosome-recycling factor, mitochondrial; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity); Belongs to the RRF family. (262 aa)
Mrps528S ribosomal protein S5, mitochondrial; Belongs to the universal ribosomal protein uS5 family. (432 aa)
Mrpl939S ribosomal protein L9, mitochondrial; Belongs to the bacterial ribosomal protein bL9 family. (265 aa)
Mrpl3739S ribosomal protein L37, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL37 family. (423 aa)
Mrps1528S ribosomal protein S15, mitochondrial; Belongs to the universal ribosomal protein uS15 family. (258 aa)
Mrpl2039S ribosomal protein L20, mitochondrial; Belongs to the bacterial ribosomal protein bL20 family. (149 aa)
Mrpl3339S ribosomal protein L33, mitochondrial; Belongs to the bacterial ribosomal protein bL33 family. (65 aa)
Mrps3328S ribosomal protein S33, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS33 family. (106 aa)
Mrpl1939S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family. (292 aa)
Mrpl5139S ribosomal protein L51, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL51 family. (128 aa)
Mrps1128S ribosomal protein S11, mitochondrial; Belongs to the universal ribosomal protein uS11 family. (191 aa)
Mrpl4639S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family. (283 aa)
Mrps3128S ribosomal protein S31, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS31 family. (384 aa)
Mrps2228S ribosomal protein S22, mitochondrial. (359 aa)
Mrpl339S ribosomal protein L3, mitochondrial; Belongs to the universal ribosomal protein uL3 family. (348 aa)
Mrps228S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation. (291 aa)
Mrps628S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. (125 aa)
Gadd45gip1Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. (222 aa)
Mrps2828S ribosomal protein S28, mitochondrial; Belongs to the bacterial ribosomal protein bS1 family. (186 aa)
Mrpl2339S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family. (146 aa)
Mrpl5439S ribosomal protein L54, mitochondrial. (135 aa)
TsfmElongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (324 aa)
Ppp1r26Protein phosphatase 1 regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. (1163 aa)
Mrpl4139S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. (135 aa)
Mrpl1239S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family. (201 aa)
Mrpl3439S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family. (92 aa)
Mrps3428S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. Belongs to the mitochondrion-specific ribosomal protein mS34 family. (218 aa)
Mrpl4739S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family. (252 aa)
Mrps3528S ribosomal protein S35, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS35 family. (320 aa)
Mrps728S ribosomal protein S7, mitochondrial; Belongs to the universal ribosomal protein uS7 family. (242 aa)
Mrps1628S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family. (135 aa)
Mrps928S ribosomal protein S9, mitochondrial; Belongs to the universal ribosomal protein uS9 family. (390 aa)
Mrps2728S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues. (415 aa)
Mrpl5039S ribosomal protein L50, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL50 family. (159 aa)
Mrpl3539S ribosomal protein L35, mitochondrial. (188 aa)
Mrps2128S ribosomal protein S21, mitochondrial; Belongs to the bacterial ribosomal protein bS21 family. (87 aa)
Chchd1Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; Belongs to the mitochondrion-specific ribosomal protein mS37 family. (118 aa)
Mrpl4239S ribosomal protein L42, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL42 family. (142 aa)
Gfm1Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...] (751 aa)
Mrpl1839S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity). (180 aa)
Ptcd3Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation. (685 aa)
Rpl560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa)
Aurkaip1Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation; Belongs to the mitochondrion-specific ribosomal protein mS38 family. (200 aa)
Dap328S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death. Belongs to the mitochondrion-specific ribosomal protein mS29 family. (396 aa)
Mrpl4339S ribosomal protein L43, mitochondrial. (159 aa)
TufmElongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (452 aa)
Ccdc105Coiled-coil domain-containing protein 105. (499 aa)
Mrpl5539S ribosomal protein L55, mitochondrial. (134 aa)
Mrps3628S ribosomal protein S36, mitochondrial. (102 aa)
Mrpl5339S ribosomal protein L53, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL53 family. (118 aa)
Mrpl3939S ribosomal protein L39, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL39 family. (336 aa)
Mrps1728S ribosomal protein S17, mitochondrial; Belongs to the universal ribosomal protein uS17 family. (120 aa)
Mrpl139S ribosomal protein L1, mitochondrial. (336 aa)
Mrps1028S ribosomal protein S10, mitochondrial; Belongs to the universal ribosomal protein uS10 family. (201 aa)
Mrpl2439S ribosomal protein L24, mitochondrial; Belongs to the universal ribosomal protein uL24 family. (216 aa)
Mrps2528S ribosomal protein S25, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS25 family. (171 aa)
Mrpl1539S ribosomal protein L15, mitochondrial. (295 aa)
Mrpl4839S ribosomal protein L48, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL48 family. (211 aa)
Mrpl58Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity). (206 aa)
Mrpl1739S ribosomal protein L17, mitochondrial. (176 aa)
Mrps2428S ribosomal protein S24, mitochondrial; Belongs to the universal ribosomal protein uS3 family. (167 aa)
Mrps1428S ribosomal protein S14, mitochondrial; Belongs to the universal ribosomal protein uS14 family. (128 aa)
Mrps2628S ribosomal protein S26, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS26 family. (200 aa)
Gm10260Ribosomal protein S18, pseudogene 6; Belongs to the universal ribosomal protein uS13 family. (152 aa)
Mrpl1639S ribosomal protein L16, mitochondrial; Belongs to the universal ribosomal protein uL16 family. (251 aa)
Mrpl1339S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family. (178 aa)
Mrps1228S ribosomal protein S12, mitochondrial; Belongs to the universal ribosomal protein uS12 family. (139 aa)
Spdye4cSpeedy/RINGO cell cycle regulator family, member E4C. (339 aa)
Mrpl3239S ribosomal protein L32, mitochondrial; Belongs to the bacterial ribosomal protein bL32 family. (187 aa)
Gm49711Predicted gene, 49711. (117 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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