(15 nodes) Organellar large ribosomal subunit network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Mrpl10	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family. (262 aa)
	Mrpl49	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family. (166 aa)
	Mrpl45	39S ribosomal protein L45, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL45 family. (306 aa)
	Mrpl40	39S ribosomal protein L40, mitochondrial. (206 aa)
	Mrpl30	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family. (160 aa)
	Mrpl44	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily. (333 aa)
	Mrpl37	39S ribosomal protein L37, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL37 family. (423 aa)
	Mrpl46	39S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family. (283 aa)
	Mrpl23	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family. (146 aa)
	Mrpl41	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. (135 aa)
	Mrpl34	39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family. (92 aa)
	Mrpl47	39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family. (252 aa)
	Mrpl18	39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity). (180 aa)
	Mrpl43	39S ribosomal protein L43, mitochondrial. (159 aa)
	Mrpl39	39S ribosomal protein L39, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL39 family. (336 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Mrpl10	Mrpl18	ENSMUSP00000001485	ENSMUSP00000078123	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).	0.893
Mrpl10	Mrpl23	ENSMUSP00000001485	ENSMUSP00000039784	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	0.944
Mrpl10	Mrpl30	ENSMUSP00000001485	ENSMUSP00000027256	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	0.944
Mrpl10	Mrpl34	ENSMUSP00000001485	ENSMUSP00000044497	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family.	0.956
Mrpl10	Mrpl37	ENSMUSP00000001485	ENSMUSP00000030365	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L37, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL37 family.	0.854
Mrpl10	Mrpl39	ENSMUSP00000001485	ENSMUSP00000112283	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L39, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL39 family.	0.899
Mrpl10	Mrpl40	ENSMUSP00000001485	ENSMUSP00000023391	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L40, mitochondrial.	0.968
Mrpl10	Mrpl41	ENSMUSP00000001485	ENSMUSP00000043561	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.	0.971
Mrpl10	Mrpl43	ENSMUSP00000001485	ENSMUSP00000095322	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L43, mitochondrial.	0.943
Mrpl10	Mrpl44	ENSMUSP00000001485	ENSMUSP00000027464	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily.	0.964
Mrpl10	Mrpl45	ENSMUSP00000001485	ENSMUSP00000019026	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L45, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL45 family.	0.924
Mrpl10	Mrpl46	ENSMUSP00000001485	ENSMUSP00000032841	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family.	0.964
Mrpl10	Mrpl47	ENSMUSP00000001485	ENSMUSP00000048078	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family.	0.957
Mrpl10	Mrpl49	ENSMUSP00000001485	ENSMUSP00000007482	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.	0.974
Mrpl18	Mrpl10	ENSMUSP00000078123	ENSMUSP00000001485	39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).	39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family.	0.893
Mrpl18	Mrpl23	ENSMUSP00000078123	ENSMUSP00000039784	39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	0.866
Mrpl18	Mrpl30	ENSMUSP00000078123	ENSMUSP00000027256	39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	0.885
Mrpl18	Mrpl34	ENSMUSP00000078123	ENSMUSP00000044497	39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).	39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family.	0.855
Mrpl18	Mrpl37	ENSMUSP00000078123	ENSMUSP00000030365	39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).	39S ribosomal protein L37, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL37 family.	0.880
Mrpl18	Mrpl39	ENSMUSP00000078123	ENSMUSP00000112283	39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).	39S ribosomal protein L39, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL39 family.	0.908