(10 nodes) Organellar large ribosomal subunit network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Mrpl49	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family. (166 aa)
	Mrpl40	39S ribosomal protein L40, mitochondrial. (206 aa)
	Mrpl30	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family. (160 aa)
	Mrpl44	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily. (333 aa)
	Mrpl46	39S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family. (283 aa)
	Mrpl23	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family. (146 aa)
	Mrpl41	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. (135 aa)
	Mrpl34	39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family. (92 aa)
	Mrpl47	39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family. (252 aa)
	Mrpl43	39S ribosomal protein L43, mitochondrial. (159 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Mrpl23	Mrpl30	ENSMUSP00000039784	ENSMUSP00000027256	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	0.993
Mrpl23	Mrpl34	ENSMUSP00000039784	ENSMUSP00000044497	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family.	0.984
Mrpl23	Mrpl40	ENSMUSP00000039784	ENSMUSP00000023391	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L40, mitochondrial.	0.986
Mrpl23	Mrpl41	ENSMUSP00000039784	ENSMUSP00000043561	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.	0.994
Mrpl23	Mrpl43	ENSMUSP00000039784	ENSMUSP00000095322	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L43, mitochondrial.	0.981
Mrpl23	Mrpl44	ENSMUSP00000039784	ENSMUSP00000027464	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily.	0.784
Mrpl23	Mrpl46	ENSMUSP00000039784	ENSMUSP00000032841	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family.	0.990
Mrpl23	Mrpl47	ENSMUSP00000039784	ENSMUSP00000048078	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family.	0.993
Mrpl23	Mrpl49	ENSMUSP00000039784	ENSMUSP00000007482	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.	0.986
Mrpl30	Mrpl23	ENSMUSP00000027256	ENSMUSP00000039784	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	0.993
Mrpl30	Mrpl34	ENSMUSP00000027256	ENSMUSP00000044497	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family.	0.990
Mrpl30	Mrpl40	ENSMUSP00000027256	ENSMUSP00000023391	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L40, mitochondrial.	0.994
Mrpl30	Mrpl41	ENSMUSP00000027256	ENSMUSP00000043561	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.	0.992
Mrpl30	Mrpl43	ENSMUSP00000027256	ENSMUSP00000095322	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L43, mitochondrial.	0.989
Mrpl30	Mrpl44	ENSMUSP00000027256	ENSMUSP00000027464	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily.	0.981
Mrpl30	Mrpl46	ENSMUSP00000027256	ENSMUSP00000032841	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family.	0.986
Mrpl30	Mrpl47	ENSMUSP00000027256	ENSMUSP00000048078	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family.	0.995
Mrpl30	Mrpl49	ENSMUSP00000027256	ENSMUSP00000007482	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.	0.990
Mrpl34	Mrpl23	ENSMUSP00000044497	ENSMUSP00000039784	39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family.	39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.	0.984
Mrpl34	Mrpl30	ENSMUSP00000044497	ENSMUSP00000027256	39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family.	39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family.	0.990