(17 nodes) Organellar large ribosomal subunit network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Mrpl4	39S ribosomal protein L4, mitochondrial; Belongs to the universal ribosomal protein uL4 family. (294 aa)
	Mrpl22	39S ribosomal protein L22, mitochondrial; Belongs to the universal ribosomal protein uL22 family. (206 aa)
	Mrpl36	39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. (102 aa)
	Mrpl27	39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. (148 aa)
	Mrpl21	39S ribosomal protein L21, mitochondrial. (216 aa)
	Mrpl9	39S ribosomal protein L9, mitochondrial; Belongs to the bacterial ribosomal protein bL9 family. (265 aa)
	Mrpl20	39S ribosomal protein L20, mitochondrial; Belongs to the bacterial ribosomal protein bL20 family. (149 aa)
	Mrpl33	39S ribosomal protein L33, mitochondrial; Belongs to the bacterial ribosomal protein bL33 family. (65 aa)
	Mrpl19	39S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family. (292 aa)
	Mrpl3	39S ribosomal protein L3, mitochondrial; Belongs to the universal ribosomal protein uL3 family. (348 aa)
	Mrpl12	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family. (201 aa)
	Rpl5	60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa)
	Tufm	Elongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (452 aa)
	Mrpl17	39S ribosomal protein L17, mitochondrial. (176 aa)
	Mrpl16	39S ribosomal protein L16, mitochondrial; Belongs to the universal ribosomal protein uL16 family. (251 aa)
	Mrpl13	39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family. (178 aa)
	Mrpl32	39S ribosomal protein L32, mitochondrial; Belongs to the bacterial ribosomal protein bL32 family. (187 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Mrpl12	Mrpl13	ENSMUSP00000044417	ENSMUSP00000130722	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family.	0.984
Mrpl12	Mrpl16	ENSMUSP00000044417	ENSMUSP00000128915	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L16, mitochondrial; Belongs to the universal ribosomal protein uL16 family.	0.974
Mrpl12	Mrpl17	ENSMUSP00000044417	ENSMUSP00000117971	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L17, mitochondrial.	0.999
Mrpl12	Mrpl19	ENSMUSP00000044417	ENSMUSP00000032124	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family.	0.999
Mrpl12	Mrpl20	ENSMUSP00000044417	ENSMUSP00000030942	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L20, mitochondrial; Belongs to the bacterial ribosomal protein bL20 family.	0.999
Mrpl12	Mrpl21	ENSMUSP00000044417	ENSMUSP00000025745	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L21, mitochondrial.	0.999
Mrpl12	Mrpl22	ENSMUSP00000044417	ENSMUSP00000020820	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L22, mitochondrial; Belongs to the universal ribosomal protein uL22 family.	0.980
Mrpl12	Mrpl27	ENSMUSP00000044417	ENSMUSP00000025278	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family.	0.999
Mrpl12	Mrpl3	ENSMUSP00000044417	ENSMUSP00000035177	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L3, mitochondrial; Belongs to the universal ribosomal protein uL3 family.	0.992
Mrpl12	Mrpl32	ENSMUSP00000044417	ENSMUSP00000152345	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L32, mitochondrial; Belongs to the bacterial ribosomal protein bL32 family.	0.999
Mrpl12	Mrpl33	ENSMUSP00000044417	ENSMUSP00000031024	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L33, mitochondrial; Belongs to the bacterial ribosomal protein bL33 family.	0.999
Mrpl12	Mrpl36	ENSMUSP00000044417	ENSMUSP00000022098	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family.	0.999
Mrpl12	Mrpl4	ENSMUSP00000044417	ENSMUSP00000003386	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L4, mitochondrial; Belongs to the universal ribosomal protein uL4 family.	0.990
Mrpl12	Mrpl9	ENSMUSP00000044417	ENSMUSP00000029786	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	39S ribosomal protein L9, mitochondrial; Belongs to the bacterial ribosomal protein bL9 family.	0.999
Mrpl12	Rpl5	ENSMUSP00000044417	ENSMUSP00000080854	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]	0.999
Mrpl12	Tufm	ENSMUSP00000044417	ENSMUSP00000095656	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	Elongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.993
Mrpl13	Mrpl12	ENSMUSP00000130722	ENSMUSP00000044417	39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family.	39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.	0.984
Mrpl13	Mrpl16	ENSMUSP00000130722	ENSMUSP00000128915	39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family.	39S ribosomal protein L16, mitochondrial; Belongs to the universal ribosomal protein uL16 family.	0.995
Mrpl13	Mrpl17	ENSMUSP00000130722	ENSMUSP00000117971	39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family.	39S ribosomal protein L17, mitochondrial.	0.996
Mrpl13	Mrpl19	ENSMUSP00000130722	ENSMUSP00000032124	39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family.	39S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family.	0.996