STRINGSTRING
Crnkl1 Crnkl1 Fam32a Fam32a Cwc15 Cwc15 Bcas2 Bcas2 Cwc25 Cwc25 Xab2 Xab2 Slu7 Slu7 Snw1 Snw1 Cdc5l Cdc5l Ppil1 Ppil1 Rbm22 Rbm22 Cwf19l2 Cwf19l2 Ctnnbl1 Ctnnbl1 Syf2 Syf2 Wdr25 Wdr25 Dhx8 Dhx8 Sde2 Sde2 Prpf18 Prpf18 Cdc40 Cdc40 Aqr Aqr Dhx38 Dhx38 Cactin Cactin Lrrc51 Lrrc51 Yju2 Yju2 Isy1 Isy1 Plrg1 Plrg1 Srrm3 Srrm3 Prkrip1 Prkrip1 Bud31 Bud31 Prpf19 Prpf19 Gm45140 Gm45140 Gm9044 Gm9044 Gm9049 Gm9049 Gm9040 Gm9040 Gm32802 Gm32802 Gm9048 Gm9048 Gm32717 Gm32717 Gm9045 Gm9045 Gm9046 Gm9046
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Crnkl1Crooked neck-like protein 1; Involved in pre-mRNA splicing process. (690 aa)
Fam32aProtein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. (112 aa)
Cwc15Spliceosome-associated protein CWC15 homolog; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. (229 aa)
Bcas2Pre-mRNA-splicing factor SPF27; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19- CDC5L complex may also play a role in the response to DNA damage (DDR). (225 aa)
Cwc25Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family. (416 aa)
Xab2Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing; Belongs to the crooked-neck family. (855 aa)
Slu7Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. (585 aa)
Snw1SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] (536 aa)
Cdc5lCell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Belongs to the CEF1 family. (802 aa)
Ppil1Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (166 aa)
Rbm22Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses; Belongs to the SLT11 family. (420 aa)
Cwf19l2CWF19-like protein 2. (887 aa)
Ctnnbl1Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May induce apoptosis (By similarity). Participates in AID/AICDA-mediated Ig class switching recombination (CSR). (563 aa)
Syf2Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the SYF2 family. (242 aa)
Wdr25WD repeat-containing protein 25. (535 aa)
Dhx8ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. (1244 aa)
Sde2Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] (448 aa)
Prpf18Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing. (342 aa)
Cdc40Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. (579 aa)
AqrRNA helicase aquarius; Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre- mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron- encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the [...] (1481 aa)
Dhx38DEAH (Asp-Glu-Ala-His) box polypeptide 38. (1228 aa)
CactinCactin; Involved in the regulation of innate immune response (By similarity). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (By similarity). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). Belongs to the CACTIN family. (772 aa)
Lrrc51Leucine-rich repeat-containing protein 51. (192 aa)
Yju2Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. (314 aa)
Isy1Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an in [...] (285 aa)
Plrg1Pleiotropic regulator 1; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. (513 aa)
Srrm3Serine/arginine repetitive matrix protein 3; May play a role in regulating breast cancer cell invasiveness. May be involved in RYBP-mediated breast cancer progression; Belongs to the CWC21 family. (648 aa)
Prkrip1PRKR-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity. (186 aa)
Bud31Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. (144 aa)
Prpf19Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] (523 aa)
Gm45140Predicted gene 45140. (118 aa)
Gm9044Predicted gene 9040. (802 aa)
Gm9049Predicted gene 9045. (802 aa)
Gm9040Predicted gene 9040. (802 aa)
Gm32802Predicted gene, 32717. (802 aa)
Gm9048Predicted gene 9048. (802 aa)
Gm32717Predicted gene, 32717. (802 aa)
Gm9045Predicted gene 9045. (802 aa)
Gm9046Predicted gene 9046. (802 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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