STRINGSTRING
Calr Calr H2-M10.2 H2-M10.2 Tapbp Tapbp H2-K1 H2-K1 H2-Oa H2-Oa Tap2 Tap2 H2-M10.1 H2-M10.1 Mr1 Mr1 Pdia3 Pdia3 Cd1d1 Cd1d1 Calr4 Calr4 Klrc1 Klrc1 Nucb2 Nucb2 H2-M3 H2-M3 Gm8909 Gm8909 H2-DMa H2-DMa H2-M10.6 H2-M10.6 H2-M1 H2-M1 Gm7030 Gm7030 H2-Ab1 H2-Ab1 H2-M11 H2-M11 H2-DMb2 H2-DMb2 H2-Aa H2-Aa Tapbpl Tapbpl H2-M10.5 H2-M10.5 H2-Eb2 H2-Eb2 H2-M10.4 H2-M10.4 H2-Q7 H2-Q7 H2-Q1 H2-Q1 H2-M10.3 H2-M10.3 H2-Q2 H2-Q2 H2-T22 H2-T22 H2-Q4 H2-Q4 H2-M9 H2-M9 H2-Ob H2-Ob Cd74 Cd74 B2m B2m H2-T3 H2-T3 H2-T23 H2-T23 Klra3 Klra3 Klrd1 Klrd1 Kir3dl2 Kir3dl2 Gm11127 Gm11127 H2-T24 H2-T24 H2-DMb1 H2-DMb1 Tap1 Tap1 H2-M2 H2-M2 H2-M5 H2-M5 Trgc3 Trgc3 Erap1 Erap1 H2-Q10 H2-Q10 H2-Q6 H2-Q6 Canx Canx H2-Eb1 H2-Eb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CalrCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. (416 aa)
H2-M10.2Histocompatibility 2, M region locus 10.2; Belongs to the MHC class I family. (329 aa)
TapbpTapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). (466 aa)
H2-K1H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (369 aa)
H2-OaHistocompatibility 2, O region alpha locus; Belongs to the MHC class II family. (250 aa)
Tap2Antigen peptide transporter 2; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. (702 aa)
H2-M10.1Histocompatibility 2, M region locus 10.1; Belongs to the MHC class I family. (331 aa)
Mr1Major histocompatibility complex class I-related gene protein; Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites (By similarity). Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. (341 aa)
Pdia3Protein disulfide-isomerase A3. (505 aa)
Cd1d1Antigen-presenting glycoprotein CD1d1; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. (336 aa)
Calr4Calreticulin. (420 aa)
Klrc1Killer cell lectin-like receptor subfamily C, member 1. (244 aa)
Nucb2Nucleobindin-2; Calcium-binding protein which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). (420 aa)
H2-M3Histocompatibility 2, M region locus 3; Belongs to the MHC class I family. (336 aa)
Gm8909Predicted gene 8909; Belongs to the MHC class I family. (368 aa)
H2-DMaClass II histocompatibility antigen, M alpha chain; Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides. (261 aa)
H2-M10.6Major histocompatibility complex class Ib M10.8; Belongs to the MHC class I family. (330 aa)
H2-M1Histocompatibility 2, M region locus 1; Belongs to the MHC class I family. (344 aa)
Gm7030Predicted gene 7030; Belongs to the MHC class I family. (285 aa)
H2-Ab1H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family. (265 aa)
H2-M11Histocompatibility 2, M region locus 11; Belongs to the MHC class I family. (335 aa)
H2-DMb2Histocompatibility 2, class II, locus Mb2. (261 aa)
H2-AaH-2 class II histocompatibility antigen, A-B alpha chain. (256 aa)
TapbplTapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. (451 aa)
H2-M10.5Histocompatibility 2, M region locus 10.5; Belongs to the MHC class I family. (330 aa)
H2-Eb2Histocompatibility 2, class II antigen E beta2. (287 aa)
H2-M10.4Histocompatibility 2, M region locus 10.4; Belongs to the MHC class I family. (331 aa)
H2-Q7H-2 class I histocompatibility antigen, Q7 alpha chain; Involved in the presentation of foreign antigens to the immune system. (334 aa)
H2-Q1Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family. (368 aa)
H2-M10.3Major histocompatibility complex class Ib M10.3; Belongs to the MHC class I family. (330 aa)
H2-Q2Histocompatibility 2, Q region locus 2; Belongs to the MHC class I family. (360 aa)
H2-T22Histocompatibility 2, T region locus 22; Belongs to the MHC class I family. (379 aa)
H2-Q4Histocompatibility 2, Q region locus 4; Belongs to the MHC class I family. (354 aa)
H2-M9Histocompatibility 2, M region locus 9; Belongs to the MHC class I family. (342 aa)
H2-ObHistocompatibility 2, O region beta locus. (271 aa)
Cd74H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. (279 aa)
B2mBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family. (119 aa)
H2-T3H-2 class I histocompatibility antigen, TLA(B) alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (384 aa)
H2-T23H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system. (357 aa)
Klra3Killer cell lectin-like receptor 3; Receptor on natural killer (NK) cells for class I MHC. (266 aa)
Klrd1Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)
Kir3dl2Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2. (388 aa)
Gm11127Predicted gene 11127; Belongs to the MHC class I family. (374 aa)
H2-T24Histocompatibility 2, T region locus 24; Belongs to the MHC class I family. (363 aa)
H2-DMb1Class II histocompatibility antigen, M beta 1 chain; Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides; Belongs to the MHC class II family. (261 aa)
Tap1Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. (724 aa)
H2-M2Histocompatibility 2, M region locus 2; Belongs to the MHC class I family. (343 aa)
H2-M5Histocompatibility 2, M region locus 5; Belongs to the MHC class I family. (348 aa)
Trgc3T-cell receptor gamma chain C region C7.5. (172 aa)
Erap1Endoplasmic reticulum aminopeptidase 1; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play [...] (930 aa)
H2-Q10H-2 class I histocompatibility antigen, Q10 alpha chain; Involved in the presentation of foreign antigens to the immune system. (325 aa)
H2-Q6H-2 class I histocompatibility antigen, Q8 alpha chain; Involved in the presentation of foreign antigens to the immune system. (326 aa)
CanxCalnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] (591 aa)
H2-Eb1H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family. (264 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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