STRINGSTRING
Cd52 Cd52 Ptpn6 Ptpn6 Klra17 Klra17 Ly86 Ly86 Cd180 Cd180 Clec4n Clec4n Ms4a7 Ms4a7 Ms4a6d Ms4a6d Batf3 Batf3 Ly75 Ly75 Zbtb46 Zbtb46 Fcgr1 Fcgr1 Clec4e Clec4e Clec4d Clec4d Clec4a2 Clec4a2 Pglyrp1 Pglyrp1 Cd37 Cd37 Cd53 Cd53 Trem1 Trem1 Oscar Oscar Lilra6 Lilra6 Trem3 Trem3 Batf2 Batf2 Ms4a4b Ms4a4b Cd300ld Cd300ld Clec1a Clec1a Cd200r1 Cd200r1 Cd300e Cd300e A530064D06Rik A530064D06Rik Clec9a Clec9a Siglech Siglech Sirpb1c Sirpb1c Clec12a Clec12a Gm14548 Gm14548 9830107B12Rik 9830107B12Rik Ms4a4c Ms4a4c Cd302 Cd302 Clec4b1 Clec4b1 Lilrb4a Lilrb4a Fcgr4 Fcgr4 Clec4a4 Clec4a4 Lair1 Lair1 Clec4b2 Clec4b2 Clec4a3 Clec4a3 Sirpb1b Sirpb1b Lyz1 Lyz1 Lyz2 Lyz2 Cd300c2 Cd300c2 Cd300c Cd300c Wfdc17 Wfdc17 Cd47 Cd47 Lilr4b Lilr4b Cd300lf Cd300lf Cd300lb Cd300lb Cd300a Cd300a Pira2 Pira2 Plac8 Plac8 Mpeg1 Mpeg1 Lilra5 Lilra5 Treml4 Treml4 Gm15448 Gm15448 Sirpa Sirpa Ms4a6b Ms4a6b Cd200 Cd200 Fcgr3 Fcgr3 Ms4a6c Ms4a6c Gm8369 Gm8369 Cd200r4 Cd200r4 Gm5150 Gm5150 Sirpb1a Sirpb1a Ifitm6 Ifitm6 Treml1 Treml1 Treml2 Treml2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cd52CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. (74 aa)
Ptpn6Tyrosine-protein phosphatase non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
Klra17Killer cell lectin-like receptor, subfamily A, member 17. (273 aa)
Ly86Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. (162 aa)
Cd180CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B- cells. (661 aa)
Clec4nC-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk- CARD9-NF [...] (209 aa)
Ms4a7Membrane-spanning 4-domains, subfamily A, member 7. (267 aa)
Ms4a6dMembrane-spanning 4-domains subfamily A member 6D; May be involved in signal transduction as a component of a multimeric receptor complex. (247 aa)
Batf3Basic leucine zipper transcriptional factor ATF-like 3; AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8- alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Belongs to the bZIP family. (118 aa)
Ly75Lymphocyte antigen 75; Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity). (1723 aa)
Zbtb46Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1. (600 aa)
Fcgr1High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. (404 aa)
Clec4eC-type lectin domain family 4 member E; A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolat [...] (214 aa)
Clec4dC-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shapin [...] (219 aa)
Clec4a2C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. (262 aa)
Pglyrp1Peptidoglycan recognition protein 1; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. May function in intracellular killing of bacteria. The soluble form triggers apoptosis in vitro. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (182 aa)
Cd37Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. (303 aa)
Cd53Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells. (219 aa)
Trem1Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). (230 aa)
OscarOsteoclast-associated immunoglobulin-like receptor; Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. (271 aa)
Lilra6Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6. (663 aa)
Trem3Triggering receptor expressed on myeloid cells 3; Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response. (183 aa)
Batf2Basic leucine zipper transcriptional factor ATF-like 2; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CCN1 promoter (By similarity). Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts [...] (277 aa)
Ms4a4bMembrane-spanning 4-domains, subfamily A, member 4B. (226 aa)
Cd300ldCMRF35-like molecule 5; Acts as an activating receptor in myeloid cells and mast cells; Belongs to the CD300 family. (221 aa)
Clec1aC-type lectin domain family 1 member A. (269 aa)
Cd200r1Cell surface glycoprotein CD200 receptor 1; Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. (326 aa)
Cd300eCMRF35-like molecule 2; Probably acts as an activating receptor. (196 aa)
A530064D06RikTriggering receptor expressed in myeloid cells 4. (229 aa)
Clec9aC-type lectin domain family 9 member A; Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. (264 aa)
SiglechSialic acid-binding Ig-like lectin H. (309 aa)
Sirpb1cSignal-regulatory protein beta 1C. (391 aa)
Clec12aC-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. (267 aa)
Gm14548Predicted gene 14548. (680 aa)
9830107B12RikRIKEN cDNA 9830107B12 gene. (160 aa)
Ms4a4cMembrane-spanning 4-domains, subfamily A, member 4C. (226 aa)
Cd302CD302 antigen; Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. (228 aa)
Clec4b1Dendritic cell immuno-activating receptor alpha isoform. (209 aa)
Lilrb4aLeukocyte immunoglobulin-like receptor subfamily B member 4; Receptor for class I MHC antigens. Involved in the down- regulation of the immune response and the development of tolerance. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (By similarity). (335 aa)
Fcgr4Low affinity immunoglobulin gamma Fc region receptor IV; Receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Can bind to IgG2a and IgG2b monomers. Does not display binding to IgG1 or IgG3. Mediates neutrophil activation by IgG complexes redundantly with Fcgr3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to I [...] (249 aa)
Clec4a4C-type lectin domain family 4, member a4. (236 aa)
Lair1Leukocyte-associated immunoglobulin-like receptor 1; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T- cells, down-regulating IL2 and IFNG production while induc [...] (263 aa)
Clec4b2Antigen presenting cell lectin-like receptor A1. (208 aa)
Clec4a3C-type lectin domain family 4, member a3. (237 aa)
Sirpb1bSignal-regulatory protein beta 1B. (391 aa)
Lyz1Lysozyme C-1; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-positive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria; Belongs to the glycosyl hydrolase 22 family. (148 aa)
Lyz2Lysozyme C-2; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria; Belongs to the glycosyl hydrolase 22 family. (148 aa)
Cd300c2CMRF-35-like molecule 4; Acts as an activating receptor in mast cells and macrophages. Belongs to the CD300 family. (228 aa)
Cd300cCMRF35-like molecule 6. (229 aa)
Wfdc17Activated macrophage/microglia WAP domain protein. (76 aa)
Cd47Leukocyte surface antigen CD47; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integ [...] (324 aa)
Lilr4bMast cell surface glycoprotein Gp49A; May play a role in cell-cell or cell-cytokine interactions during the development of mast cells. (303 aa)
Cd300lfCMRF35-like molecule 1; Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage- mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide which act [...] (337 aa)
Cd300lbCMRF35-like molecule 7; Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP. (255 aa)
Cd300aCMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). (318 aa)
Pira2Paired-Ig-like receptor A2. (680 aa)
Plac8Placenta-specific gene 8 protein; Belongs to the cornifelin family. (112 aa)
Mpeg1Macrophage-expressed gene 1 protein; Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogene [...] (720 aa)
Lilra5Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5. (295 aa)
Treml4Trem-like transcript 4 protein; Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand- induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but [...] (264 aa)
Gm15448Predicted gene 15448. (682 aa)
SirpaTyrosine-protein phosphatase non-receptor type substrate 1; Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative re [...] (513 aa)
Ms4a6bMembrane-spanning 4-domains subfamily A member 6B; May be involved in signal transduction as a component of a multimeric receptor complex. (244 aa)
Cd200OX-2 membrane glycoprotein; Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity). (278 aa)
Fcgr3Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b. Mediates neutrophil activation by IgG complexes redundantly with Fcgr4. (267 aa)
Ms4a6cMembrane-spanning 4-domains subfamily A member 6C; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (217 aa)
Gm8369Predicted gene 8369. (166 aa)
Cd200r4Cell surface glycoprotein CD200 receptor 4; Involved in the recruitment or surface expression of the TYROBP receptor. Belongs to the CD200R family. (270 aa)
Gm5150SIRP beta 1 like 1 protein. (299 aa)
Sirpb1aSignal-regulatory protein beta 1A. (391 aa)
Ifitm6Interferon-induced transmembrane protein 6. (104 aa)
Treml1Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. (322 aa)
Treml2Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity). (329 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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