STRINGSTRING
Cd52 Cd52 Ly86 Ly86 Cd180 Cd180 Ms4a7 Ms4a7 Ms4a6d Ms4a6d Cd37 Cd37 Cd53 Cd53 Ms4a4b Ms4a4b Ms4a4c Ms4a4c Lyz1 Lyz1 Lyz2 Lyz2 Wfdc17 Wfdc17 Plac8 Plac8 Mpeg1 Mpeg1 Ms4a6b Ms4a6b Ms4a6c Ms4a6c Gm8369 Gm8369 Ifitm6 Ifitm6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cd52CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. (74 aa)
Ly86Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. (162 aa)
Cd180CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B- cells. (661 aa)
Ms4a7Membrane-spanning 4-domains, subfamily A, member 7. (267 aa)
Ms4a6dMembrane-spanning 4-domains subfamily A member 6D; May be involved in signal transduction as a component of a multimeric receptor complex. (247 aa)
Cd37Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. (303 aa)
Cd53Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells. (219 aa)
Ms4a4bMembrane-spanning 4-domains, subfamily A, member 4B. (226 aa)
Ms4a4cMembrane-spanning 4-domains, subfamily A, member 4C. (226 aa)
Lyz1Lysozyme C-1; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-positive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria; Belongs to the glycosyl hydrolase 22 family. (148 aa)
Lyz2Lysozyme C-2; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria; Belongs to the glycosyl hydrolase 22 family. (148 aa)
Wfdc17Activated macrophage/microglia WAP domain protein. (76 aa)
Plac8Placenta-specific gene 8 protein; Belongs to the cornifelin family. (112 aa)
Mpeg1Macrophage-expressed gene 1 protein; Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogene [...] (720 aa)
Ms4a6bMembrane-spanning 4-domains subfamily A member 6B; May be involved in signal transduction as a component of a multimeric receptor complex. (244 aa)
Ms4a6cMembrane-spanning 4-domains subfamily A member 6C; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (217 aa)
Gm8369Predicted gene 8369. (166 aa)
Ifitm6Interferon-induced transmembrane protein 6. (104 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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