Predicted gene 16286.

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

Predicted gene 16286.

N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine (By similarity). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development (By similarity). Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell mi [...]

Predicted gene 16286.

N-alpha-acetyltransferase 11; Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

Predicted gene 16286.

N-alpha-acetyltransferase 15, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Predicted gene 16286.

N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Predicted gene 16286.

N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.

Predicted gene 16286.

N-alpha-acetyltransferase 25, NatB auxiliary subunit; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. Belongs to the MDM20/NAA25 family.

Predicted gene 16286.

N-alpha-acetyltransferase 30; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.

Predicted gene 16286.

N-alpha-acetyltransferase 35, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

Predicted gene 16286.

N-alpha-acetyltransferase 38, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues; Belongs to the snRNP Sm proteins family.

Predicted gene 16286.

N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...]

Predicted gene 16286.

N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N- terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences; Belongs to the ace [...]

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

Predicted gene 16286.

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine (By similarity). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development (By similarity). Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell mi [...]

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

N-alpha-acetyltransferase 11; Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

N-alpha-acetyltransferase 15, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

N-alpha-acetyltransferase 25, NatB auxiliary subunit; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. Belongs to the MDM20/NAA25 family.

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity).

N-alpha-acetyltransferase 30; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.