(8 nodes) Mixed, incl. SET domain, and Lebercilin-like network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Map3k7cl	MAP3K7 C-terminal-like protein. (142 aa)
	Akip1	A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). (212 aa)
	Lca5	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. (704 aa)
	Tspear	Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. (670 aa)
	Prdm15	PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...] (1174 aa)
	C2cd2	C2 domain-containing protein 2. (696 aa)
	Shisa8	Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses. (399 aa)
	Setd4	SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. (439 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akip1	C2cd2	ENSMUSP00000033335	ENSMUSP00000127368	A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity).	C2 domain-containing protein 2.	0.641
Akip1	Lca5	ENSMUSP00000033335	ENSMUSP00000034791	A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity).	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	0.647
Akip1	Prdm15	ENSMUSP00000033335	ENSMUSP00000093533	A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity).	PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...]	0.495
Akip1	Shisa8	ENSMUSP00000033335	ENSMUSP00000137002	A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity).	Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.	0.552
C2cd2	Akip1	ENSMUSP00000127368	ENSMUSP00000033335	C2 domain-containing protein 2.	A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity).	0.641
C2cd2	Lca5	ENSMUSP00000127368	ENSMUSP00000034791	C2 domain-containing protein 2.	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	0.653
C2cd2	Prdm15	ENSMUSP00000127368	ENSMUSP00000093533	C2 domain-containing protein 2.	PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...]	0.712
C2cd2	Setd4	ENSMUSP00000127368	ENSMUSP00000156723	C2 domain-containing protein 2.	SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.	0.603
C2cd2	Shisa8	ENSMUSP00000127368	ENSMUSP00000137002	C2 domain-containing protein 2.	Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.	0.792
C2cd2	Tspear	ENSMUSP00000127368	ENSMUSP00000090020	C2 domain-containing protein 2.	Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.	0.726
Lca5	Akip1	ENSMUSP00000034791	ENSMUSP00000033335	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity).	0.647
Lca5	C2cd2	ENSMUSP00000034791	ENSMUSP00000127368	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	C2 domain-containing protein 2.	0.653
Lca5	Map3k7cl	ENSMUSP00000034791	ENSMUSP00000026700	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	MAP3K7 C-terminal-like protein.	0.674
Lca5	Prdm15	ENSMUSP00000034791	ENSMUSP00000093533	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...]	0.665
Lca5	Setd4	ENSMUSP00000034791	ENSMUSP00000156723	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.	0.441
Lca5	Shisa8	ENSMUSP00000034791	ENSMUSP00000137002	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.	0.489
Lca5	Tspear	ENSMUSP00000034791	ENSMUSP00000090020	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.	0.661
Map3k7cl	Lca5	ENSMUSP00000026700	ENSMUSP00000034791	MAP3K7 C-terminal-like protein.	Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	0.674
Map3k7cl	Prdm15	ENSMUSP00000026700	ENSMUSP00000093533	MAP3K7 C-terminal-like protein.	PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...]	0.700
Map3k7cl	Setd4	ENSMUSP00000026700	ENSMUSP00000156723	MAP3K7 C-terminal-like protein.	SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.	0.572