(12 nodes) Mixed, incl. Threonine catabolic process, and D-serine metabolic process network (Mus musculus)

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Your Input:
	Gnmt	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. (293 aa)
	Gcat	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (416 aa)
	Pipox	Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. (390 aa)
	Tdh	L-threonine 3-dehydrogenase, mitochondrial; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate, mediating L-threonine catabolism. Belongs to the NAD(P)-dependent epimerase/dehydratase family. (373 aa)
	Sdsl	Serine dehydratase-like; Has low serine dehydratase and threonine dehydratase activity; Belongs to the serine/threonine dehydratase family. (329 aa)
	Tha1	L-threonine aldolase. (400 aa)
	Alas2	5-aminolevulinate synthase, erythroid-specific, mitochondrial. (587 aa)
	Srr	Serine racemase; Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. (339 aa)
	Sardh	Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. (919 aa)
	Dao	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. (345 aa)
	Alas1	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (642 aa)
	Sds	L-serine dehydratase/L-threonine deaminase; Belongs to the serine/threonine dehydratase family. (327 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alas1	Alas2	ENSMUSP00000117014	ENSMUSP00000066040	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	0.908
Alas1	Dao	ENSMUSP00000117014	ENSMUSP00000107911	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	0.915
Alas1	Gcat	ENSMUSP00000117014	ENSMUSP00000006544	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	0.913
Alas1	Gnmt	ENSMUSP00000117014	ENSMUSP00000002846	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.	0.903
Alas1	Pipox	ENSMUSP00000117014	ENSMUSP00000017597	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline.	0.912
Alas1	Sardh	ENSMUSP00000117014	ENSMUSP00000099950	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family.	0.940
Alas1	Tha1	ENSMUSP00000117014	ENSMUSP00000033230	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	L-threonine aldolase.	0.919
Alas2	Alas1	ENSMUSP00000066040	ENSMUSP00000117014	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	0.908
Alas2	Dao	ENSMUSP00000066040	ENSMUSP00000107911	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	0.913
Alas2	Gcat	ENSMUSP00000066040	ENSMUSP00000006544	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	0.911
Alas2	Gnmt	ENSMUSP00000066040	ENSMUSP00000002846	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.	0.913
Alas2	Pipox	ENSMUSP00000066040	ENSMUSP00000017597	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline.	0.925
Alas2	Sardh	ENSMUSP00000066040	ENSMUSP00000099950	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family.	0.936
Alas2	Tha1	ENSMUSP00000066040	ENSMUSP00000033230	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	L-threonine aldolase.	0.920
Dao	Alas1	ENSMUSP00000107911	ENSMUSP00000117014	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	0.915
Dao	Alas2	ENSMUSP00000107911	ENSMUSP00000066040	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	5-aminolevulinate synthase, erythroid-specific, mitochondrial.	0.913
Dao	Gcat	ENSMUSP00000107911	ENSMUSP00000006544	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	0.917
Dao	Gnmt	ENSMUSP00000107911	ENSMUSP00000002846	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.	0.910
Dao	Pipox	ENSMUSP00000107911	ENSMUSP00000017597	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline.	0.953
Dao	Sardh	ENSMUSP00000107911	ENSMUSP00000099950	D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family.	0.952