| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Alas2 | Dao | ENSMUSP00000066040 | ENSMUSP00000107911 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | 0.913 |
| Alas2 | Gnmt | ENSMUSP00000066040 | ENSMUSP00000002846 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | 0.913 |
| Alas2 | Pipox | ENSMUSP00000066040 | ENSMUSP00000017597 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.925 |
| Alas2 | Sardh | ENSMUSP00000066040 | ENSMUSP00000099950 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | 0.936 |
| Dao | Alas2 | ENSMUSP00000107911 | ENSMUSP00000066040 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.913 |
| Dao | Gnmt | ENSMUSP00000107911 | ENSMUSP00000002846 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | 0.910 |
| Dao | Pipox | ENSMUSP00000107911 | ENSMUSP00000017597 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.953 |
| Dao | Sardh | ENSMUSP00000107911 | ENSMUSP00000099950 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | 0.952 |
| Gnmt | Alas2 | ENSMUSP00000002846 | ENSMUSP00000066040 | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.913 |
| Gnmt | Dao | ENSMUSP00000002846 | ENSMUSP00000107911 | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | 0.910 |
| Gnmt | Pipox | ENSMUSP00000002846 | ENSMUSP00000017597 | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.954 |
| Gnmt | Sardh | ENSMUSP00000002846 | ENSMUSP00000099950 | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | 0.982 |
| Pipox | Alas2 | ENSMUSP00000017597 | ENSMUSP00000066040 | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.925 |
| Pipox | Dao | ENSMUSP00000017597 | ENSMUSP00000107911 | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | 0.953 |
| Pipox | Gnmt | ENSMUSP00000017597 | ENSMUSP00000002846 | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | 0.954 |
| Pipox | Sardh | ENSMUSP00000017597 | ENSMUSP00000099950 | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | 0.981 |
| Sardh | Alas2 | ENSMUSP00000099950 | ENSMUSP00000066040 | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.936 |
| Sardh | Dao | ENSMUSP00000099950 | ENSMUSP00000107911 | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | 0.952 |
| Sardh | Gnmt | ENSMUSP00000099950 | ENSMUSP00000002846 | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | 0.982 |
| Sardh | Pipox | ENSMUSP00000099950 | ENSMUSP00000017597 | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.981 |