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Cyp2b13 Cyp2b13 Cyp2a5 Cyp2a5 Aldh1a3 Aldh1a3 Cyp2c39 Cyp2c39 Ugt2b35 Ugt2b35 Sult1e1 Sult1e1 Cyp3a16 Cyp3a16 Cyp3a13 Cyp3a13 Ces2a Ces2a Ugt1a2 Ugt1a2 Cyp3a44 Cyp3a44 Cyp2b10 Cyp2b10 Ugt1a1 Ugt1a1 Cyp26c1 Cyp26c1 Cyp3a41b Cyp3a41b Ugt2b37 Ugt2b37 Cyp2b19 Cyp2b19 Cyp2b9 Cyp2b9 Cyp4a12a Cyp4a12a Cyp2a4 Cyp2a4 Cyp2c68 Cyp2c68 Ugt1a10 Ugt1a10 Ugt2a1 Ugt2a1 Cyp4a29 Cyp4a29 Cyp26b1 Cyp26b1 Cyp1a1 Cyp1a1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Cyp2b13Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family. (491 aa)
Cyp2a5Cytochrome P450 2A5; Exhibits a high coumarin 7-hydroxylase activity. (494 aa)
Aldh1a3Aldehyde dehydrogenase family 1 member A3; NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (By similarity). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region. (512 aa)
Cyp2c39Cytochrome P450 2C39; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET); Belongs to the cytochrome P450 family. (490 aa)
Ugt2b35UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
Sult1e1Sulfotransferase 1E1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone, pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). (295 aa)
Cyp3a16Cytochrome P450 3A16; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (504 aa)
Cyp3a13Cytochrome P450 3A13; Can activate aflatoxin B1 to a genotoxic product. (503 aa)
Ces2aPyrethroid hydrolase Ces2a; Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes permethrin faster than cypermethrin. (558 aa)
Ugt1a2UDP-glucuronosyltransferase 1-2; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (533 aa)
Cyp3a44Cytochrome P450, family 3, subfamily a, polypeptide 44. (504 aa)
Cyp2b10Cytochrome P450 2B10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
Ugt1a1UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. (535 aa)
Cyp26c1Cytochrome P450, family 26, subfamily c, polypeptide 1; Belongs to the cytochrome P450 family. (518 aa)
Cyp3a41bCytochrome P450 3A41. (504 aa)
Ugt2b37UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
Cyp2b19Cytochrome P450 2B19; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (492 aa)
Cyp2b9Cytochrome P450 2B9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
Cyp4a12aCytochrome P450 4A12A; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] (508 aa)
Cyp2a4Cytochrome P450 2A4; Highly active in the 15-alpha-hydroxylation of testosterone. Also active in the 15-alpha-hydroxylation of progesterone and androstenedione. Little or no activity on corticosterone, pregnenolone, dehydroepiandrosterone, estradiol or estriol; Belongs to the cytochrome P450 family. (494 aa)
Cyp2c68Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. (491 aa)
Ugt1a10UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
Ugt2a1UDP-glucuronosyltransferase 2A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium. (528 aa)
Cyp4a29Cytochrome P450, family 4, subfamily a, polypeptide 29; Belongs to the cytochrome P450 family. (509 aa)
Cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required [...] (512 aa)
Cyp1a1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (524 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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