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Abhd17a Abhd17a Abhd16a Abhd16a Abhd8 Abhd8 Acy1 Acy1 Lipm Lipm Fam135a Fam135a Abhd2 Abhd2 Ephx4 Ephx4 Fbxo28 Fbxo28 Abhd10 Abhd10 Abhd16b Abhd16b Abhd15 Abhd15 Abhd18 Abhd18 Abhd3 Abhd3 Abhd13 Abhd13 Abhd14a Abhd14a Abhd12b Abhd12b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Abhd17aAlpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towars MAP6. (310 aa)
Abhd16aPhosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes. Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). Belongs to the AB hydrolase superfamily. ABHD16 [...] (558 aa)
Abhd8Protein ABHD8; Belongs to the AB hydrolase superfamily. (439 aa)
Acy1Aminoacylase-1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate); Belongs to the peptidase M20A family. (408 aa)
LipmLipase member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). Belongs to the AB hydrolase superfamily. Lipase family. (422 aa)
Fam135aProtein FAM135A. (1506 aa)
Abhd2Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] (425 aa)
Ephx4Epoxide hydrolase 4. (359 aa)
Fbxo28F-box only protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. (368 aa)
Abhd10Mycophenolic acid acyl-glucuronide esterase, mitochondrial. (297 aa)
Abhd16bProtein ABHD16B; Belongs to the AB hydrolase superfamily. ABHD16 family. (474 aa)
Abhd15Protein ABHD15. (459 aa)
Abhd18Protein ABHD18; Belongs to the AB hydrolase superfamily. (464 aa)
Abhd3Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. (411 aa)
Abhd13Protein ABHD13. (337 aa)
Abhd14aProtein ABHD14A; Possible role in granule neuron development. Belongs to the AB hydrolase superfamily. ABHD14 family. (266 aa)
Abhd12bAbhydrolase domain-containing 12B. (359 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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