STRINGSTRING
Fbxo9 Fbxo9 Ccdc97 Ccdc97 Htra1 Htra1 Slc44a4 Slc44a4 Zcchc10 Zcchc10 Nudt13 Nudt13 Rcbtb1 Rcbtb1 Ttc33 Ttc33 Gpatch3 Gpatch3 Sema4b Sema4b Fbxl19 Fbxl19 Prr14 Prr14 Snx20 Snx20 Fam192a Fam192a Slc44a2 Slc44a2 Dcbld2 Dcbld2 Slc44a3 Slc44a3 Vwa1 Vwa1 Fbxw17 Fbxw17 Fam53a Fam53a Fkbp14 Fkbp14 Tmtc4 Tmtc4 Ptpn13 Ptpn13 Gpbp1 Gpbp1 Plekha4 Plekha4 Slc17a5 Slc17a5 Rspry1 Rspry1 Phxr2 Phxr2 Tpra1 Tpra1 Tmcc3 Tmcc3 Plekha2 Plekha2 Ficd Ficd Plekha1 Plekha1 Znrf2 Znrf2 Plekha5 Plekha5 Fbxw9 Fbxw9 Gm12888 Gm12888 Zfp408 Zfp408 Plekhn1 Plekhn1 Plekhg5 Plekhg5 Gm12886 Gm12886 Ccdc106 Ccdc106 Plekha3 Plekha3 Plekha8 Plekha8 Prss53 Prss53 Coch Coch Ttc6 Ttc6 Zfp428 Zfp428 Samd11 Samd11 Mturn Mturn Tmem241 Tmem241 Gm8773 Gm8773 Ubl7 Ubl7 Nudt16l1 Nudt16l1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Fbxo9F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] (437 aa)
Ccdc97Coiled-coil domain-containing protein 97. (340 aa)
Htra1Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits sign [...] (480 aa)
Slc44a4Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis. Belongs to the CTL (choline transporter-like) family. (707 aa)
Zcchc10Zinc finger CCHC domain-containing protein 10. (178 aa)
Nudt13Nucleoside diphosphate-linked moiety X motif 13. (352 aa)
Rcbtb1RCC1 and BTB domain-containing protein 1; May be involved in cell cycle regulation by chromatin remodeling. (531 aa)
Ttc33Tetratricopeptide repeat protein 33. (262 aa)
Gpatch3G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6. (525 aa)
Sema4bSemaphorin-4B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons; Belongs to the semaphorin family. (823 aa)
Fbxl19F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (By similarity). (674 aa)
Prr14Proline-rich protein 14; Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (By similarity). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (By similarity). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (By similarity). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferatio [...] (612 aa)
Snx20Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, nor on SELPLG-mediated cell-cell adhesion. (313 aa)
Fam192aPSME3-interacting protein; Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. (254 aa)
Slc44a2Choline transporter-like protein 2; Choline transporter; Belongs to the CTL (choline transporter-like) family. (706 aa)
Dcbld2Discoidin, CUB and LCCL domain-containing protein 2. (769 aa)
Slc44a3Choline transporter-like protein 3. (656 aa)
Vwa1Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. (415 aa)
Fbxw17F-box and WD-40 domain protein 17. (466 aa)
Fam53aProtein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle. Belongs to the FAM53 family. (402 aa)
Fkbp14Peptidyl-prolyl cis-trans isomerase FKBP14; PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4- hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. (211 aa)
Tmtc4Protein O-mannosyl-transferase TMTC4; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. (741 aa)
Ptpn13Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (2451 aa)
Gpbp1Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor. (493 aa)
Plekha4Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. (779 aa)
Slc17a5Sialin; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva (By similarity). (495 aa)
Rspry1RING finger and SPRY domain-containing protein 1. (576 aa)
Phxr2Putative per-hexamer repeat protein 2. (65 aa)
Tpra1Transmembrane protein adipocyte-associated 1. (369 aa)
Tmcc3Transmembrane and coiled-coil domain protein 3; Belongs to the TEX28 family. (477 aa)
Plekha2Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. (425 aa)
FicdProtein adenylyltransferase FICD; Protein that can both mediate the addition of adenosine 5'- monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (By similarity). In unstressed cel [...] (458 aa)
Plekha1Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). (383 aa)
Znrf2E3 ubiquitin-protein ligase ZNRF2; May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (238 aa)
Plekha5Pleckstrin homology domain-containing, family A member 5. (1269 aa)
Fbxw9F-box and WD-40 domain protein 9. (458 aa)
Gm12888Predicted gene 12888. (119 aa)
Zfp408Zinc finger protein 408. (710 aa)
Plekhn1Kelch-like protein 17; Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). (640 aa)
Plekhg5Pleckstrin homology domain-containing family G member 5; Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity). (1073 aa)
Gm12886Predicted gene 12886. (119 aa)
Ccdc106Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. (341 aa)
Plekha3Pleckstrin homology domain-containing family A member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4- phosphate (PtdIns4P) (By similarity). (297 aa)
Plekha8Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non- vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation [...] (519 aa)
Prss53Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Belongs to the peptidase S1 family. (552 aa)
CochCochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. (552 aa)
Ttc6Tetratricopeptide repeat domain 6. (1857 aa)
Zfp428Zinc finger protein 428. (189 aa)
Samd11Sterile alpha motif domain-containing protein 11; May play a role in photoreceptor development. (552 aa)
MturnMaturin; Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression. Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity). (148 aa)
Tmem241Transmembrane protein 241; Belongs to the TMEM241 family. (297 aa)
Gm8773Predicted gene 8773. (132 aa)
Ubl7Ubiquitin-like protein 7. (380 aa)
Nudt16l1Tudor-interacting repair regulator protein; Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain an [...] (211 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.