node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dusp18 | Ptpn21 | ENSMUSP00000057346 | ENSMUSP00000082197 | Dual specificity protein phosphatase 18; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). | Tyrosine-protein phosphatase non-receptor type 21; May be involved in the regulation of growth and differentiation of liver cells; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.484 |
Fam57b | Ms4a8a | ENSMUSP00000078392 | ENSMUSP00000025636 | Ceramide synthase; Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis. | Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex. | 0.579 |
Fam57b | Nxph3 | ENSMUSP00000078392 | ENSMUSP00000058254 | Ceramide synthase; Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis. | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins; Belongs to the neurexophilin family. | 0.507 |
Fam57b | Ptpn21 | ENSMUSP00000078392 | ENSMUSP00000082197 | Ceramide synthase; Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis. | Tyrosine-protein phosphatase non-receptor type 21; May be involved in the regulation of growth and differentiation of liver cells; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.496 |
Gm5127 | Ms4a8a | ENSMUSP00000098855 | ENSMUSP00000025636 | Predicted gene, EG331493. | Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex. | 0.515 |
Gm5127 | Nxph3 | ENSMUSP00000098855 | ENSMUSP00000058254 | Predicted gene, EG331493. | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins; Belongs to the neurexophilin family. | 0.483 |
Gm5127 | Ptpn21 | ENSMUSP00000098855 | ENSMUSP00000082197 | Predicted gene, EG331493. | Tyrosine-protein phosphatase non-receptor type 21; May be involved in the regulation of growth and differentiation of liver cells; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.434 |
Ms4a8a | Fam57b | ENSMUSP00000025636 | ENSMUSP00000078392 | Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex. | Ceramide synthase; Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis. | 0.579 |
Ms4a8a | Gm5127 | ENSMUSP00000025636 | ENSMUSP00000098855 | Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex. | Predicted gene, EG331493. | 0.515 |
Nxph3 | Fam57b | ENSMUSP00000058254 | ENSMUSP00000078392 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins; Belongs to the neurexophilin family. | Ceramide synthase; Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis. | 0.507 |
Nxph3 | Gm5127 | ENSMUSP00000058254 | ENSMUSP00000098855 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins; Belongs to the neurexophilin family. | Predicted gene, EG331493. | 0.483 |
Ptpn21 | Dusp18 | ENSMUSP00000082197 | ENSMUSP00000057346 | Tyrosine-protein phosphatase non-receptor type 21; May be involved in the regulation of growth and differentiation of liver cells; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Dual specificity protein phosphatase 18; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). | 0.484 |
Ptpn21 | Fam57b | ENSMUSP00000082197 | ENSMUSP00000078392 | Tyrosine-protein phosphatase non-receptor type 21; May be involved in the regulation of growth and differentiation of liver cells; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Ceramide synthase; Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis. | 0.496 |
Ptpn21 | Gm5127 | ENSMUSP00000082197 | ENSMUSP00000098855 | Tyrosine-protein phosphatase non-receptor type 21; May be involved in the regulation of growth and differentiation of liver cells; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Predicted gene, EG331493. | 0.434 |