STRINGSTRING
Ovgp1 Ovgp1 Slc46a1 Slc46a1 Clgn Clgn Zp3 Zp3 Adam21 Adam21 Calr3 Calr3 Rnase10 Rnase10 Adam2 Adam2 Zp1 Zp1 Fpgs Fpgs Llcfc1 Llcfc1 Prss37 Prss37 Izumo1 Izumo1 Zp2 Zp2 Pdilt Pdilt Adam3 Adam3 Cmtm2a Cmtm2a Izumo1r Izumo1r Tcam1 Tcam1 4930451I11Rik 4930451I11Rik Adam24 Adam24 Prss54 Prss54 Adam6a Adam6a Adam30 Adam30 Tas2r134 Tas2r134 Dcst1 Dcst1 Tex37 Tex37 Tssk5 Tssk5 Adam1b Adam1b Izumo2 Izumo2 Prss55 Prss55 Adam25 Adam25 Ggh Ggh Prss44 Prss44 Adam1a Adam1a Slc19a1 Slc19a1 Folr1 Folr1 Izumo3 Izumo3 Tex55 Tex55 Spaca6 Spaca6 Isoc2a Isoc2a Tmem95 Tmem95 Hyal5 Hyal5 Dcst2 Dcst2 Folr2 Folr2 Izumo4 Izumo4 Prss30 Prss30
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ovgp1Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. (721 aa)
Slc46a1Proton-coupled folate transporter; Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. (459 aa)
ClgnCalmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions. Belongs to the calreticulin family. (611 aa)
Zp3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily. (424 aa)
Adam21Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. (729 aa)
Calr3Calreticulin-3; CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. (380 aa)
Rnase10Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity. (245 aa)
Adam2Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). (735 aa)
Zp1Processed zona pellucida sperm-binding protein 1; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida. (623 aa)
FpgsFolylpolyglutamate synthase, mitochondrial; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10- methylenetetrahydrofolate, 10-formyltetrahydrofolate and 5- formyltetrahydrofolate are the best substrates. Folic acid and 5- methyltetrahydrofolate can also act [...] (587 aa)
Llcfc1LLLL and CFNLAS motif-containing protein 1. (108 aa)
Prss37Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity). (237 aa)
Izumo1Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. (397 aa)
Zp2Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. (713 aa)
PdiltProtein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis. (588 aa)
Adam3A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct. (822 aa)
Cmtm2aCKLF-like MARVEL transmembrane domain-containing protein 2A; Belongs to the chemokine-like factor family. (169 aa)
Izumo1rSperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. (244 aa)
Tcam1Testicular cell adhesion molecule 1. (548 aa)
4930451I11RikRIKEN cDNA 4930451I11 gene. (111 aa)
Adam24Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization. (761 aa)
Prss54Inactive serine protease 54. (383 aa)
Adam6aA disintegrin and metallopeptidase domain 6A. (754 aa)
Adam30A disintegrin and metallopeptidase domain 30. (732 aa)
Tas2r134Taste receptor type 2 member 134; Putative taste receptor which may play a role in the perception of bitterness. (298 aa)
Dcst1E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. (732 aa)
Tex37Testis-expressed sequence 37 protein. (180 aa)
Tssk5Testis-specific serine/threonine-protein kinase 5; May be involved in a signaling pathway during male germ cell development or mature sperm function; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (372 aa)
Adam1bDisintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. (806 aa)
Izumo2Izumo sperm-egg fusion protein 2. (193 aa)
Prss55Serine protease 55; Probable serine protease; Belongs to the peptidase S1 family. (321 aa)
Adam25Disintegrin and metalloproteinase domain-containing protein 25; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. (760 aa)
GghGamma-glutamyl hydrolase; Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Acts as endopeptidase. Lysosomal enzyme is activated by sulfhydryl compounds. (317 aa)
Prss44Serine protease 44; Belongs to the peptidase S1 family. (372 aa)
Adam1aDisintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion. (791 aa)
Slc19a1Reduced folate transporter; Transporter that mediates the import of reduced folates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (By similarity). 5-amino-4- imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity). (512 aa)
Folr1Folate receptor alpha; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. (255 aa)
Izumo3Izumo sperm-egg fusion protein 3. (263 aa)
Tex55Testis-specific expressed protein 55. (381 aa)
Spaca6Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion. (339 aa)
Isoc2aIsochorismatase domain-containing protein 2A. (206 aa)
Tmem95Transmembrane protein 95. (176 aa)
Hyal5Hyaluronidase-5; Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments. Does not appear to be essential for fertilization. (526 aa)
Dcst2DC-STAMP domain-containing 2. (701 aa)
Folr2Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). (251 aa)
Izumo4Izumo sperm-egg fusion protein 4. (227 aa)
Prss30Serine protease 30; Selectively cleaves synthetic peptide substrates of trypsin. Activates the epithelial sodium channel ENaC (By similarity). Belongs to the peptidase S1 family. (310 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.