(15 nodes) Mixed, incl. Calreticulin family, and Regulation of fertilization network (Mus musculus)

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Your Input:
	Clgn	Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions. Belongs to the calreticulin family. (611 aa)
	Calr3	Calreticulin-3; CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. (380 aa)
	Rnase10	Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity. (245 aa)
	Prss37	Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity). (237 aa)
	Pdilt	Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis. (588 aa)
	Adam3	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct. (822 aa)
	Cmtm2a	CKLF-like MARVEL transmembrane domain-containing protein 2A; Belongs to the chemokine-like factor family. (169 aa)
	Adam24	Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization. (761 aa)
	Prss54	Inactive serine protease 54. (383 aa)
	Adam6a	A disintegrin and metallopeptidase domain 6A. (754 aa)
	Tex37	Testis-expressed sequence 37 protein. (180 aa)
	Prss55	Serine protease 55; Probable serine protease; Belongs to the peptidase S1 family. (321 aa)
	Prss44	Serine protease 44; Belongs to the peptidase S1 family. (372 aa)
	Adam1a	Disintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion. (791 aa)
	Tex55	Testis-specific expressed protein 55. (381 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam1a	Calr3	ENSMUSP00000098320	ENSMUSP00000019876	Disintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion.	Calreticulin-3; CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility.	0.672
Adam1a	Clgn	ENSMUSP00000098320	ENSMUSP00000002259	Disintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion.	Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions. Belongs to the calreticulin family.	0.712
Adam1a	Pdilt	ENSMUSP00000098320	ENSMUSP00000033267	Disintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion.	Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis.	0.693
Adam1a	Prss37	ENSMUSP00000098320	ENSMUSP00000031967	Disintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion.	Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity).	0.554
Adam1a	Prss55	ENSMUSP00000098320	ENSMUSP00000086752	Disintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion.	Serine protease 55; Probable serine protease; Belongs to the peptidase S1 family.	0.482
Adam1a	Rnase10	ENSMUSP00000098320	ENSMUSP00000022424	Disintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion.	Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity.	0.608
Adam24	Adam3	ENSMUSP00000050727	ENSMUSP00000033958	Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	0.422
Adam24	Prss44	ENSMUSP00000050727	ENSMUSP00000095948	Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.	Serine protease 44; Belongs to the peptidase S1 family.	0.707
Adam24	Prss54	ENSMUSP00000050727	ENSMUSP00000058859	Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.	Inactive serine protease 54.	0.687
Adam24	Prss55	ENSMUSP00000050727	ENSMUSP00000086752	Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.	Serine protease 55; Probable serine protease; Belongs to the peptidase S1 family.	0.613
Adam24	Tex37	ENSMUSP00000050727	ENSMUSP00000066786	Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.	Testis-expressed sequence 37 protein.	0.648
Adam24	Tex55	ENSMUSP00000050727	ENSMUSP00000113120	Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.	Testis-specific expressed protein 55.	0.728
Adam3	Adam24	ENSMUSP00000033958	ENSMUSP00000050727	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.	0.422
Adam3	Adam6a	ENSMUSP00000033958	ENSMUSP00000059315	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	A disintegrin and metallopeptidase domain 6A.	0.443
Adam3	Calr3	ENSMUSP00000033958	ENSMUSP00000019876	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	Calreticulin-3; CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility.	0.784
Adam3	Clgn	ENSMUSP00000033958	ENSMUSP00000002259	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions. Belongs to the calreticulin family.	0.816
Adam3	Cmtm2a	ENSMUSP00000033958	ENSMUSP00000034344	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	CKLF-like MARVEL transmembrane domain-containing protein 2A; Belongs to the chemokine-like factor family.	0.551
Adam3	Pdilt	ENSMUSP00000033958	ENSMUSP00000033267	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis.	0.900
Adam3	Prss37	ENSMUSP00000033958	ENSMUSP00000031967	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity).	0.730
Adam3	Prss44	ENSMUSP00000033958	ENSMUSP00000095948	A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.	Serine protease 44; Belongs to the peptidase S1 family.	0.512