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| | Jup | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (745 aa) |
| | Casp14 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. (257 aa) |
| | Krt14 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. (484 aa) |
| | Krt13 | Keratin, type I cytoskeletal 13. (437 aa) |
| | Krt16 | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. (469 aa) |
| | Klk10 | Kallikrein-related-peptidase 10; Belongs to the peptidase S1 family. (278 aa) |
| | Dsg4 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. (1041 aa) |
| | Perp | P53 apoptosis effector related to PMP-22; Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. (193 aa) |
| | Nipal4 | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity); Belongs to the NIPA family. (406 aa) |
| | Blmh | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. (455 aa) |
| | Aloxe3 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] (711 aa) |
| | Krt5 | Keratin, type II cytoskeletal 5. (580 aa) |
| | Krt6b | Keratin, type II cytoskeletal 6B; Belongs to the intermediate filament family. (554 aa) |
| | Krt6a | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. (553 aa) |
| | Krt1 | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. (637 aa) |
| | Krt4 | Keratin, type II cytoskeletal 4. (525 aa) |
| | Lipn | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). Belongs to the AB hydrolase superfamily. Lipase family. (400 aa) |
| | Serpinb3a | Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A; Belongs to the serpin family. (387 aa) |
| | Pkp1 | Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. (728 aa) |
| | Tgm5 | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. (724 aa) |
| | Tchhl1 | Trichohyalin-like protein 1; Belongs to the S-100 family. (638 aa) |
| | Lce1m | Late cornified envelope 1M. (182 aa) |
| | Crct1 | Cysteine-rich C-terminal 1. (102 aa) |
| | Lce1d | Late cornified envelope 1D. (133 aa) |
| | Lce1g | Late cornified envelope 1G. (139 aa) |
| | Lce1a2 | Late cornified envelope 1A2. (149 aa) |
| | Lce1b | Late cornified envelope 1B. (137 aa) |
| | Sprr2j-ps | Putative small proline-rich protein 2J; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (109 aa) |
| | Lelp1 | Late cornified envelope-like proline-rich protein 1; Belongs to the cornifin (SPRR) family. (120 aa) |
| | Klk7 | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. (249 aa) |
| | Trex2 | Three prime repair exonuclease 2; Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. (236 aa) |
| | Pkp2 | Plakophilin 2. (795 aa) |
| | Lce1f | Late cornified envelope 1F. (147 aa) |
| | Evpl | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. (2035 aa) |
| | Ppl | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. (1754 aa) |
| | Sprr2d | Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (85 aa) |
| | Eps8l3 | Epidermal growth factor receptor kinase substrate 8-like protein 3. (600 aa) |
| | Dsc1 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. (832 aa) |
| | Sprr2i | Small proline-rich protein 2I; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (76 aa) |
| | Rptn | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein; Belongs to the S100-fused protein family. (1118 aa) |
| | Lce1c | Late cornified envelope 1C. (147 aa) |
| | Asprv1 | Retroviral-like aspartic protease 1. (339 aa) |
| | Lce3b | Late cornified envelope 3B. (98 aa) |
| | Cdsn | Corneodesmosin; Important for the epidermal barrier integrity. (561 aa) |
| | Klk5 | Kallikrein-related-peptidase 5; Belongs to the peptidase S1 family. (293 aa) |
| | Pnpla1 | Patatin-like phospholipase domain-containing protein 1; Lipid hydrolase. (599 aa) |
| | Sfn | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. (248 aa) |
| | Lce3c | Late cornified envelope 3C. (98 aa) |
| | Sprr2f | Small proline-rich protein 2F; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (76 aa) |
| | Sprr4 | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification (By similarity). (76 aa) |
| | Lor | Loricrin; Major keratinocyte cell envelope protein. (486 aa) |
| | Sprr1a | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. May participate widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility; Belongs to the cornifin (SPRR) family. (144 aa) |
| | Sprr2h | Small proline-rich protein 2H; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity); Belongs to the cornifin (SPRR) family. (108 aa) |
| | Dsg1c | Desmoglein-1-gamma; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (911 aa) |
| | Sprr3 | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Belongs to the cornifin (SPRR) family. (238 aa) |
| | Prss27 | Serine protease 27. (328 aa) |
| | Dsg2 | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1122 aa) |
| | Lce1l | Late cornified envelope 1L. (135 aa) |
| | Sprr2b | Small proline-rich protein 2B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (98 aa) |
| | Sprr1b | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Belongs to the cornifin (SPRR) family. (153 aa) |
| | Lce1h | Late cornified envelope 1H. (140 aa) |
| | Ivl | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (468 aa) |
| | Fam25c | Protein FAM25C; Belongs to the FAM25 family. (89 aa) |
| | Sprr2k | Small proline-rich protein 2K; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (68 aa) |
| | Sprr2e | Small proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (76 aa) |
| | Dsg3 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (993 aa) |
| | Spink5 | Serine peptidase inhibitor, Kazal type 5. (1017 aa) |
| | Lce3a | Late cornified envelope 3A. (98 aa) |
| | Tchh | Trichohyalin. (1599 aa) |
| | Kprp | Keratinocyte proline-rich protein. (657 aa) |
| | Lce1a1 | Late cornified envelope 1A1. (143 aa) |
| | Dsc2 | Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. (902 aa) |
| | Dsg1b | Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1060 aa) |
| | Dsg1a | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1057 aa) |
| | Krt80 | Keratin, type II cytoskeletal 80; Belongs to the intermediate filament family. (452 aa) |
| | Sbsn | Suprabasin. (682 aa) |
| | Krt17 | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (433 aa) |
| | Serpinb12 | Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily. (423 aa) |
| | Lgals7 | Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity). (136 aa) |
| | Sprr2a1 | Small proline-rich protein 2A3; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). Belongs to the cornifin (SPRR) family. (83 aa) |
| | Abca12 | ATP-binding cassette, sub-family A (ABC1), member 12. (2595 aa) |
| | Hrnr | Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family. (3234 aa) |
| | Lce3f | Late cornified envelope 3F. (98 aa) |
| | Lce1i | Late cornified envelope 1I. (149 aa) |
| | Lce1e | Late cornified envelope 1E. (143 aa) |
| | Gm94 | Uncharacterized protein C5orf46 homolog. (93 aa) |
| | Krtdap | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). (102 aa) |
| | Flg2 | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis; Belongs to the S100-fused protein family. (2336 aa) |
| | Lce3e | Late cornified envelope 3E. (98 aa) |
| | Krt10 | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Belongs to the intermediate filament family. (561 aa) |
| | Pkp4 | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family. (1190 aa) |
| | Pkp3 | Plakophilin-3; May play a role in junctional plaques. (822 aa) |
| | Sprr2a2 | Small proline-rich protein 2A2. (83 aa) |
| | Krt15 | Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family. (456 aa) |
| | Tgm3 | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] (693 aa) |
| | Lce6a | Late cornified envelope 6A. (81 aa) |
| | Dsp | Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family. (2883 aa) |
| | Krt78 | Keratin 78; Belongs to the intermediate filament family. (1068 aa) |
| | 2310050C09Rik | RIKEN cDNA 2310050C09 gene. (280 aa) |
| | Tgm1 | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). (815 aa) |
| | Dmkn | Dermokine; May act as a soluble regulator of keratinocyte differentiation. (524 aa) |
| | Cnfn | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (124 aa) |
| | Lce3d | Late cornified envelope 3D. (98 aa) |
| | Lce1k | Late cornified envelope 1K. (125 aa) |
| | Smim5 | Small integral membrane protein 5. (78 aa) |
| | Cysrt1 | Cysteine-rich tail protein 1; Belongs to the CYSRT1 family. (142 aa) |
| | Lce1j | Late cornified envelope 1J. (139 aa) |
| | Crnn | Cornulin. (520 aa) |
| | Flg | Filaggrin. (357 aa) |
| | Sprr2a3 | Small proline-rich protein 2A3. (83 aa) |
| | Olfr1055 | Olfactory receptor. (346 aa) |
| | Dsc3 | Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. (896 aa) |
| | Apcdd1 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. (514 aa) |
