STRINGSTRING
Jup Jup Casp14 Casp14 Krt14 Krt14 Krt13 Krt13 Krt16 Krt16 Dsg4 Dsg4 Perp Perp Blmh Blmh Krt5 Krt5 Krt6b Krt6b Krt6a Krt6a Krt1 Krt1 Krt4 Krt4 Serpinb3a Serpinb3a Pkp1 Pkp1 Tchhl1 Tchhl1 Crct1 Crct1 Lelp1 Lelp1 Klk7 Klk7 Pkp2 Pkp2 Evpl Evpl Ppl Ppl Eps8l3 Eps8l3 Dsc1 Dsc1 Rptn Rptn Cdsn Cdsn Klk5 Klk5 Sfn Sfn Sprr4 Sprr4 Lor Lor Dsg1c Dsg1c Sprr3 Sprr3 Dsg2 Dsg2 Sprr1b Sprr1b Ivl Ivl Dsg3 Dsg3 Spink5 Spink5 Tchh Tchh Kprp Kprp Dsc2 Dsc2 Dsg1b Dsg1b Dsg1a Dsg1a Krt80 Krt80 Sbsn Sbsn Krt17 Krt17 Serpinb12 Serpinb12 Lgals7 Lgals7 Hrnr Hrnr Krtdap Krtdap Flg2 Flg2 Krt10 Krt10 Pkp4 Pkp4 Pkp3 Pkp3 Krt15 Krt15 Tgm3 Tgm3 Dsp Dsp Tgm1 Tgm1 Dmkn Dmkn Cnfn Cnfn Crnn Crnn Flg Flg Dsc3 Dsc3 Apcdd1 Apcdd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JupJunction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (745 aa)
Casp14Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. (257 aa)
Krt14Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. (484 aa)
Krt13Keratin, type I cytoskeletal 13. (437 aa)
Krt16Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. (469 aa)
Dsg4Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. (1041 aa)
PerpP53 apoptosis effector related to PMP-22; Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. (193 aa)
BlmhBleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. (455 aa)
Krt5Keratin, type II cytoskeletal 5. (580 aa)
Krt6bKeratin, type II cytoskeletal 6B; Belongs to the intermediate filament family. (554 aa)
Krt6aKeratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. (553 aa)
Krt1Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family. (637 aa)
Krt4Keratin, type II cytoskeletal 4. (525 aa)
Serpinb3aSerine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A; Belongs to the serpin family. (387 aa)
Pkp1Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. (728 aa)
Tchhl1Trichohyalin-like protein 1; Belongs to the S-100 family. (638 aa)
Crct1Cysteine-rich C-terminal 1. (102 aa)
Lelp1Late cornified envelope-like proline-rich protein 1; Belongs to the cornifin (SPRR) family. (120 aa)
Klk7Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. (249 aa)
Pkp2Plakophilin 2. (795 aa)
EvplEnvoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. (2035 aa)
PplPeriplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. (1754 aa)
Eps8l3Epidermal growth factor receptor kinase substrate 8-like protein 3. (600 aa)
Dsc1Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. (832 aa)
RptnRepetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein; Belongs to the S100-fused protein family. (1118 aa)
CdsnCorneodesmosin; Important for the epidermal barrier integrity. (561 aa)
Klk5Kallikrein-related-peptidase 5; Belongs to the peptidase S1 family. (293 aa)
Sfn14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. (248 aa)
Sprr4Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification (By similarity). (76 aa)
LorLoricrin; Major keratinocyte cell envelope protein. (486 aa)
Dsg1cDesmoglein-1-gamma; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (911 aa)
Sprr3Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Belongs to the cornifin (SPRR) family. (238 aa)
Dsg2Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1122 aa)
Sprr1bCornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Belongs to the cornifin (SPRR) family. (153 aa)
IvlInvolucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (468 aa)
Dsg3Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (993 aa)
Spink5Serine peptidase inhibitor, Kazal type 5. (1017 aa)
TchhTrichohyalin. (1599 aa)
KprpKeratinocyte proline-rich protein. (657 aa)
Dsc2Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. (902 aa)
Dsg1bDesmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1060 aa)
Dsg1aDesmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1057 aa)
Krt80Keratin, type II cytoskeletal 80; Belongs to the intermediate filament family. (452 aa)
SbsnSuprabasin. (682 aa)
Krt17Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (433 aa)
Serpinb12Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily. (423 aa)
Lgals7Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity). (136 aa)
HrnrHornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family. (3234 aa)
KrtdapKeratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). (102 aa)
Flg2Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis; Belongs to the S100-fused protein family. (2336 aa)
Krt10Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Belongs to the intermediate filament family. (561 aa)
Pkp4Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family. (1190 aa)
Pkp3Plakophilin-3; May play a role in junctional plaques. (822 aa)
Krt15Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family. (456 aa)
Tgm3Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] (693 aa)
DspDesmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family. (2883 aa)
Tgm1Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). (815 aa)
DmknDermokine; May act as a soluble regulator of keratinocyte differentiation. (524 aa)
CnfnCornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (124 aa)
CrnnCornulin. (520 aa)
FlgFilaggrin. (357 aa)
Dsc3Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. (896 aa)
Apcdd1Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family. (514 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.