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| | Cpa3 | Mast cell carboxypeptidase A. (417 aa) |
| | Corin | Atrial natriuretic peptide-converting enzyme, activated protease fragment; Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB [...] (1113 aa) |
| | Tmigd3 | Transmembrane domain-containing protein TMIGD3. (209 aa) |
| | Cpb1 | Carboxypeptidase B1 (Tissue). (415 aa) |
| | Mcpt2 | Mast cell protease 2. (244 aa) |
| | Gzmg | Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa) |
| | Gzmc | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa) |
| | Gzmn | Granzyme N; Belongs to the peptidase S1 family. (248 aa) |
| | Mcpt8 | Mast cell protease 8. (247 aa) |
| | F2rl2 | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. (369 aa) |
| | F2rl1 | Proteinase-activated receptor 2; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF- kappaB and Rho. Can also be transactivated by cleaved F2r/Par1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistical [...] (399 aa) |
| | Gzmf | Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa) |
| | Cma1 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily. (260 aa) |
| | Mcpt1 | Mast cell protease 1; Has a chymotrypsin-like activity. (246 aa) |
| | Cela1 | Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (266 aa) |
| | Reg2 | Lithostathine-2; Might act as an inhibitor of spontaneous calcium carbonate precipitation. (173 aa) |
| | Tpsg1 | Tryptase gamma heavy chain; Belongs to the peptidase S1 family. Tryptase subfamily. (311 aa) |
| | Clps | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. (113 aa) |
| | Spink1 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. (80 aa) |
| | Pnliprp2 | Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (482 aa) |
| | Cel | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). (599 aa) |
| | Hgfac | Hepatocyte growth factor activator short chain; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. (653 aa) |
| | Cpa1 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. (419 aa) |
| | Prss1 | Protease, serine, 1 (Trypsin 1); Belongs to the peptidase S1 family. (246 aa) |
| | Try4 | Pancreatic trypsin; Belongs to the peptidase S1 family. (246 aa) |
| | 2210010C04Rik | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. (247 aa) |
| | Ctrl | Chymotrypsin A CTRA-1; Belongs to the peptidase S1 family. (264 aa) |
| | Ctrb1 | Chymotrypsin B chain A; Belongs to the peptidase S1 family. (263 aa) |
| | St14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). (855 aa) |
| | Tmprss13 | Transmembrane protease serine 13. (548 aa) |
| | Mst1r | Macrophage-stimulating protein receptor alpha chain; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON lea [...] (1378 aa) |
| | Mst1 | Hepatocyte growth factor-like protein alpha chain. (716 aa) |
| | Cuzd1 | CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells. (607 aa) |
| | Mcpt4 | Mast cell protease 4; Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala- 5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. (246 aa) |
| | Hpn | Serine protease hepsin non-catalytic chain; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2 (By similarity). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization. (445 aa) |
| | Gm5771 | Predicted gene, EG436523; Belongs to the peptidase S1 family. (245 aa) |
| | Ctrc | Chymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity; Belongs to the peptidase S1 family. Elastase subfamily. (267 aa) |
| | Tmprss11b | Transmembrane protease serine 11B-like protein; Serine protease; Belongs to the peptidase S1 family. (416 aa) |
| | Ptk7 | Inactive tyrosine-protein kinase 7; Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. (1062 aa) |
| | Pnliprp1 | Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). (473 aa) |
| | Prss34 | Mast cell protease-11; Belongs to the peptidase S1 family. (318 aa) |
| | Serpini2 | Serpin I2; Belongs to the serpin family. (405 aa) |
| | Erv3 | Endogenous retroviral sequence 3. (200 aa) |
| | Fam124a | Family with sequence similarity 124, member A. (536 aa) |
| | Pcsk6 | Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (959 aa) |
| | F2rl3 | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. (396 aa) |
| | Pnlip | Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). (465 aa) |
| | Fcer1a | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. (250 aa) |
| | Cdcp3 | Putative DMBT1-like protein. (841 aa) |
| | Tmprss11c | Transmembrane protease serine 11C non-catalytic chain; Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro. (431 aa) |
| | Try5 | Trypsinogen 9; Belongs to the peptidase S1 family. (246 aa) |
| | Prss2 | Anionic trypsin-2. (246 aa) |
| | Try10 | Trypsinogen 10; Belongs to the peptidase S1 family. (246 aa) |
| | 1810009J06Rik | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. (247 aa) |
| | Prss43 | Putative inactive serine protease 43; Plays a role in spermatogenesis. Involved in germ cell survival during meiosis; Belongs to the peptidase S1 family. (382 aa) |
| | Lyg2 | Lysozyme g-like protein 2; May act as a potent antibacterial protein that may play a role in the innate immunity; Belongs to the glycosyl hydrolase 23 family. (213 aa) |
| | Rnase1 | Ribonuclease pancreatic; Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA (By similarity); Belongs to the pancreatic ribonuclease family. (149 aa) |
| | Gzmd | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (252 aa) |
| | Mrgpra4 | Mas-related G-protein coupled receptor member A4; Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain. (313 aa) |
| | Gzme | Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa) |
| | Cma2 | Mast cell protease 10; Belongs to the peptidase S1 family. (246 aa) |
| | Reg3d | Regenerating islet-derived 3 delta. (175 aa) |
| | Mrgprb1 | Mas-related G-protein coupled receptor member B1; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. (350 aa) |
| | Mcpt9 | Mast cell protease 9. (246 aa) |
| | Habp2 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. (517 aa) |
| | Gm10334 | Predicted gene 10334; Belongs to the peptidase S1 family. (246 aa) |
| | Prss3 | Protease, serine 3; Belongs to the peptidase S1 family. (246 aa) |
| | Cpa2 | Carboxypeptidase A2. (417 aa) |
| | Tmprss12 | Transmembrane protease serine 12. (336 aa) |
| | Reg3b | Regenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues. (175 aa) |
| | Spint2 | Kunitz-type protease inhibitor 2; Inhibitor of HGF activator. (252 aa) |
| | Tmprss11a | Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest; Belongs to the peptidase S1 family. (389 aa) |
| | Reg3a | Regenerating islet-derived protein 3-alpha 16.5 kDa form; Bactericidal C-type lectin (By similarity). Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. (175 aa) |
| | Cela2a | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (271 aa) |
| | Cela3b | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. (269 aa) |
| | Wdr95 | WD40 repeat domain 95. (642 aa) |
| | Spint1 | Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. (507 aa) |
| | Tgfbr3l | Transforming growth factor, beta receptor III-like. (297 aa) |
| | 1700011M02Rik | RIKEN cDNA 1700011M02 gene. (88 aa) |
| | Gm9112 | Predicted gene 9112. (75 aa) |
| | Tmprss7 | Transmembrane protease serine 7; Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position; Belongs to the peptidase S1 family. (829 aa) |
| | Cd200r3 | Cell surface glycoprotein CD200 receptor 3; According to isoform 4 is a receptor for the CD200 cell surface glycoprotein. According to isoform 4 is not a receptor for the CD200/OX2 cell surface glycoprotein. Isoform 1, isoform 2 and isoform 3 are involved in the recruitment or surface expression of the TYROBP receptor. Isoform 6, isoform 7 and isoform 8 are not involved in the recruitment or surface expression of the TYROBP receptor; Belongs to the CD200R family. (278 aa) |
| | Sycn | Syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. (134 aa) |
| | Klra5 | Killer cell lectin-like receptor 5; Receptor on natural killer (NK) cells for class I MHC. (266 aa) |
| | Tpsab1 | Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity). Belongs to the peptidase S1 family. Tryptase subfamily. (310 aa) |
| | Tmprss11e | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. Belongs to the peptidase S1 family. (423 aa) |
| | Ms4a2 | High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor- bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Belongs to the MS4A family. (235 aa) |
| | Gm2663 | Predicted gene 2663; Belongs to the peptidase S1 family. (247 aa) |
| | Prss51 | Protease, serine 51. (240 aa) |
| | Wdr49 | WD repeat domain 49. (710 aa) |
| | Reg1 | Lithostathine-1; Might act as an inhibitor of spontaneous calcium carbonate precipitation. (165 aa) |
| | Prss47 | Protease, serine 47; Belongs to the peptidase S1 family. (395 aa) |
| | Zg16 | Zymogen granule membrane protein 16; May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN (By similarity); Belongs to the jacalin lectin family. (167 aa) |
| | Dmbt1 | Deleted in malignant brain tumors 1 protein; May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of [...] (1957 aa) |
| | Rnh1 | Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity). (492 aa) |
| | Tpsb2 | Tryptase beta-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity. (276 aa) |
