STRINGSTRING
Cpb1 Cpb1 Cela1 Cela1 Reg2 Reg2 Clps Clps Pnliprp2 Pnliprp2 Cel Cel Cpa1 Cpa1 2210010C04Rik 2210010C04Rik Ctrl Ctrl Ctrb1 Ctrb1 Ctrc Ctrc Pnliprp1 Pnliprp1 Pnlip Pnlip Try5 Try5 Prss2 Prss2 Reg3d Reg3d Prss3 Prss3 Cpa2 Cpa2 Reg3b Reg3b Reg3a Reg3a Cela2a Cela2a Cela3b Cela3b Sycn Sycn Reg1 Reg1 Zg16 Zg16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cpb1Carboxypeptidase B1 (Tissue). (415 aa)
Cela1Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (266 aa)
Reg2Lithostathine-2; Might act as an inhibitor of spontaneous calcium carbonate precipitation. (173 aa)
ClpsColipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. (113 aa)
Pnliprp2Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (482 aa)
CelBile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). (599 aa)
Cpa1Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. (419 aa)
2210010C04RikRIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. (247 aa)
CtrlChymotrypsin A CTRA-1; Belongs to the peptidase S1 family. (264 aa)
Ctrb1Chymotrypsin B chain A; Belongs to the peptidase S1 family. (263 aa)
CtrcChymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity; Belongs to the peptidase S1 family. Elastase subfamily. (267 aa)
Pnliprp1Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). (473 aa)
PnlipPancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). (465 aa)
Try5Trypsinogen 9; Belongs to the peptidase S1 family. (246 aa)
Prss2Anionic trypsin-2. (246 aa)
Reg3dRegenerating islet-derived 3 delta. (175 aa)
Prss3Protease, serine 3; Belongs to the peptidase S1 family. (246 aa)
Cpa2Carboxypeptidase A2. (417 aa)
Reg3bRegenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues. (175 aa)
Reg3aRegenerating islet-derived protein 3-alpha 16.5 kDa form; Bactericidal C-type lectin (By similarity). Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. (175 aa)
Cela2aChymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (271 aa)
Cela3bChymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. (269 aa)
SycnSyncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. (134 aa)
Reg1Lithostathine-1; Might act as an inhibitor of spontaneous calcium carbonate precipitation. (165 aa)
Zg16Zymogen granule membrane protein 16; May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN (By similarity); Belongs to the jacalin lectin family. (167 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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