(14 nodes) Mixed, incl. Digestion of dietary lipid, and Digestion network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cpb1	Carboxypeptidase B1 (Tissue). (415 aa)
	Clps	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. (113 aa)
	Pnliprp2	Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (482 aa)
	Cel	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). (599 aa)
	Cpa1	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. (419 aa)
	2210010C04Rik	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. (247 aa)
	Ctrl	Chymotrypsin A CTRA-1; Belongs to the peptidase S1 family. (264 aa)
	Ctrb1	Chymotrypsin B chain A; Belongs to the peptidase S1 family. (263 aa)
	Pnliprp1	Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). (473 aa)
	Pnlip	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). (465 aa)
	Try5	Trypsinogen 9; Belongs to the peptidase S1 family. (246 aa)
	Prss2	Anionic trypsin-2. (246 aa)
	Cela2a	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (271 aa)
	Cela3b	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. (269 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
2210010C04Rik	Cel	ENSMUSP00000031931	ENSMUSP00000028161	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).	0.978
2210010C04Rik	Cela2a	ENSMUSP00000031931	ENSMUSP00000099539	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	0.838
2210010C04Rik	Cela3b	ENSMUSP00000031931	ENSMUSP00000099581	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	0.955
2210010C04Rik	Clps	ENSMUSP00000031931	ENSMUSP00000025062	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	0.740
2210010C04Rik	Cpa1	ENSMUSP00000031931	ENSMUSP00000031806	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	0.987
2210010C04Rik	Cpb1	ENSMUSP00000031931	ENSMUSP00000011607	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Carboxypeptidase B1 (Tissue).	0.968
2210010C04Rik	Ctrb1	ENSMUSP00000031931	ENSMUSP00000034435	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Chymotrypsin B chain A; Belongs to the peptidase S1 family.	0.951
2210010C04Rik	Ctrl	ENSMUSP00000031931	ENSMUSP00000034368	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Chymotrypsin A CTRA-1; Belongs to the peptidase S1 family.	0.961
2210010C04Rik	Pnlip	ENSMUSP00000031931	ENSMUSP00000056377	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity).	0.891
2210010C04Rik	Pnliprp1	ENSMUSP00000031931	ENSMUSP00000045465	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity).	0.751
2210010C04Rik	Pnliprp2	ENSMUSP00000031931	ENSMUSP00000026081	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	0.627
2210010C04Rik	Prss2	ENSMUSP00000031931	ENSMUSP00000065393	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Anionic trypsin-2.	0.967
2210010C04Rik	Try5	ENSMUSP00000031931	ENSMUSP00000064498	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	Trypsinogen 9; Belongs to the peptidase S1 family.	0.837
Cel	2210010C04Rik	ENSMUSP00000028161	ENSMUSP00000031931	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).	RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family.	0.978
Cel	Cela2a	ENSMUSP00000028161	ENSMUSP00000099539	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).	Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.	0.968
Cel	Cela3b	ENSMUSP00000028161	ENSMUSP00000099581	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	0.984
Cel	Clps	ENSMUSP00000028161	ENSMUSP00000025062	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	0.943
Cel	Cpa1	ENSMUSP00000028161	ENSMUSP00000031806	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	0.986
Cel	Cpb1	ENSMUSP00000028161	ENSMUSP00000011607	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).	Carboxypeptidase B1 (Tissue).	0.911
Cel	Ctrb1	ENSMUSP00000028161	ENSMUSP00000034435	Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity).	Chymotrypsin B chain A; Belongs to the peptidase S1 family.	0.991