(51 nodes) Defensin network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Serpina1f	Alpha-1-antitrypsin 1-6; Inhibitor of serine proteases. Belongs to the serpin family. (411 aa)
	Defb22	Beta-defensin 22; Probable component of sperm glycocalyx. Likely protects and facilitates transport of sperm in the female reproductive tract. Probably released from the sperm surface during capacitation. Belongs to the beta-defensin family. (179 aa)
	Defb1	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. (69 aa)
	Defb29	Beta-defensin 29; Has antibacterial activity. (78 aa)
	Spag11a	Sperm associated antigen 11A. (69 aa)
	Defb19	Beta-defensin 19; Has antibacterial activity; Belongs to the beta-defensin family. (83 aa)
	Defb36	Beta-defensin 36; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
	Defb14	Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
	Defb21	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (100 aa)
	Defb42	Beta-defensin 42; Has bactericidal activity (By similarity). May play a role in the antimicrobial protection of sperm and urogenital tract epithelia ; Belongs to the beta-defensin family. (75 aa)
	Defa39	Defensin, alpha, 39. (116 aa)
	Defa26	Alpha-defensin 26; May have microbicidal activities; Belongs to the alpha-defensin family. (93 aa)
	Defa34	Defensin, alpha, 34. (93 aa)
	Defb39	Beta-defensin 39; Has antibacterial activity. (74 aa)
	Defa21	Alpha-defensin 21; May have microbicidal activities; Belongs to the alpha-defensin family. (93 aa)
	Defa38	Defensin, alpha, 38. (116 aa)
	Defa35	Alpha-defensin 5; Probably contributes to the antimicrobial barrier function of the small bowel mucosa; Belongs to the alpha-defensin family. (93 aa)
	Defa17	Alpha-defensin 3; Probably contributes to the antimicrobial barrier function of the small bowel mucosa. (93 aa)
	Defa24	Alpha-defensin 24; May have microbicidal activities; Belongs to the alpha-defensin family. (93 aa)
	Defb4	Beta-defensin 4; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to mouse (but not human) CCR6 and induce chemotactic activity of CCR6-expressing cells. (63 aa)
	Defa37	Defensin, alpha, 36. (93 aa)
	Defa32	Alpha-defensin 20; May have microbicidal activities; Belongs to the alpha-defensin family. (95 aa)
	Defa20	Defensin, alpha, 20. (95 aa)
	Crip2	Cysteine-rich protein 2. (208 aa)
	Defa25	Alpha-defensin 25; May have microbicidal activities; Belongs to the alpha-defensin family. (92 aa)
	Defb41	Beta-defensin 41; Has bactericidal activity; Belongs to the beta-defensin family. (65 aa)
	Defb18	Beta-defensin 18; Has antibacterial activity; Belongs to the beta-defensin family. (85 aa)
	Defa28	Defensin, alpha, 28. (94 aa)
	Defa29	Alpha-defensin-related sequence 1; Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities; Belongs to the alpha-defensin family. (116 aa)
	Defa5	Alpha-defensin 5. (93 aa)
	Defa3	Defensin, alpha, 3. (93 aa)
	Defa40	Defensin, alpha, 40. (93 aa)
	Defa31	Alpha-defensin 23; May have microbicidal activities; Belongs to the alpha-defensin family. (93 aa)
	Defa22	Alpha-defensin 22. (93 aa)
	Defa30	Defensin, alpha, 30. (93 aa)
	Defa23	Defensin, alpha, 23. (93 aa)
	Defb25	Beta-defensin 25; Has antibacterial activity; Belongs to the beta-defensin family. (71 aa)
	Defb26	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (186 aa)
	Defb23	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (166 aa)
	Defb43	Beta-defensin 43; Has bactericidal activity; Belongs to the beta-defensin family. (69 aa)
	Defb47	Predicted gene, EG654465. (79 aa)
	Defb48	Predicted gene, EG432867. (87 aa)
	Defb45	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (66 aa)
	Defb20	Beta-defensin 20; Has antibacterial activity; Belongs to the beta-defensin family. (96 aa)
	Defa43	Defensin, alpha, 42. (116 aa)
	Defa41	Defensin, alpha, 41. (93 aa)
	AY761185	cDNA sequence AY761185. (94 aa)
	Defb30	Beta-defensin 30; Has antibacterial activity; Belongs to the beta-defensin family. (75 aa)
	Mptx2	Pentaxin. (219 aa)
	Defb28	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (89 aa)
	Defa27	Defensin, alpha, 27. (93 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AY761185	Defa17	ENSMUSP00000106386	ENSMUSP00000078485	cDNA sequence AY761185.	Alpha-defensin 3; Probably contributes to the antimicrobial barrier function of the small bowel mucosa.	0.410
AY761185	Defa21	ENSMUSP00000106386	ENSMUSP00000076041	cDNA sequence AY761185.	Alpha-defensin 21; May have microbicidal activities; Belongs to the alpha-defensin family.	0.416
AY761185	Defa24	ENSMUSP00000106386	ENSMUSP00000079376	cDNA sequence AY761185.	Alpha-defensin 24; May have microbicidal activities; Belongs to the alpha-defensin family.	0.400
AY761185	Defa25	ENSMUSP00000106386	ENSMUSP00000093075	cDNA sequence AY761185.	Alpha-defensin 25; May have microbicidal activities; Belongs to the alpha-defensin family.	0.423
AY761185	Defa26	ENSMUSP00000106386	ENSMUSP00000073950	cDNA sequence AY761185.	Alpha-defensin 26; May have microbicidal activities; Belongs to the alpha-defensin family.	0.423
AY761185	Defa27	ENSMUSP00000106386	ENSMUSP00000126797	cDNA sequence AY761185.	Defensin, alpha, 27.	0.400
AY761185	Defa28	ENSMUSP00000106386	ENSMUSP00000096486	cDNA sequence AY761185.	Defensin, alpha, 28.	0.400
AY761185	Defa29	ENSMUSP00000106386	ENSMUSP00000096489	cDNA sequence AY761185.	Alpha-defensin-related sequence 1; Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities; Belongs to the alpha-defensin family.	0.419
AY761185	Defa30	ENSMUSP00000106386	ENSMUSP00000096497	cDNA sequence AY761185.	Defensin, alpha, 30.	0.400
AY761185	Defa31	ENSMUSP00000106386	ENSMUSP00000096495	cDNA sequence AY761185.	Alpha-defensin 23; May have microbicidal activities; Belongs to the alpha-defensin family.	0.415
AY761185	Defa32	ENSMUSP00000106386	ENSMUSP00000081054	cDNA sequence AY761185.	Alpha-defensin 20; May have microbicidal activities; Belongs to the alpha-defensin family.	0.418
AY761185	Defa34	ENSMUSP00000106386	ENSMUSP00000074745	cDNA sequence AY761185.	Defensin, alpha, 34.	0.400
AY761185	Defa35	ENSMUSP00000106386	ENSMUSP00000077259	cDNA sequence AY761185.	Alpha-defensin 5; Probably contributes to the antimicrobial barrier function of the small bowel mucosa; Belongs to the alpha-defensin family.	0.415
AY761185	Defa37	ENSMUSP00000106386	ENSMUSP00000081053	cDNA sequence AY761185.	Defensin, alpha, 36.	0.400
AY761185	Defa38	ENSMUSP00000106386	ENSMUSP00000076665	cDNA sequence AY761185.	Defensin, alpha, 38.	0.400
AY761185	Defa39	ENSMUSP00000106386	ENSMUSP00000071783	cDNA sequence AY761185.	Defensin, alpha, 39.	0.422
AY761185	Defa40	ENSMUSP00000106386	ENSMUSP00000096494	cDNA sequence AY761185.	Defensin, alpha, 40.	0.400
AY761185	Defa41	ENSMUSP00000106386	ENSMUSP00000106382	cDNA sequence AY761185.	Defensin, alpha, 41.	0.400
AY761185	Defa43	ENSMUSP00000106386	ENSMUSP00000106377	cDNA sequence AY761185.	Defensin, alpha, 42.	0.400
AY761185	Defb1	ENSMUSP00000106386	ENSMUSP00000051754	cDNA sequence AY761185.	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family.	0.599