(10 nodes) Myosin II complex network (Mus musculus)

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	Myl6b	Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium. (207 aa)
	Myl12b	Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa)
	Myh14	Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2000 aa)
	Myh7b	Myosin-7B; Involved in muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
	Limch1	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family. (1057 aa)
	Myh10	Myosin-10; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1976 aa)
	Myh13	Myosin, heavy polypeptide 13, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
	Myl12a	Myosin, light chain 12A, regulatory, non-sarcomeric. (172 aa)
	Myl6	Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. (151 aa)
	Gm49909	Predicted gene, 49909. (172 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gm49909	Limch1	ENSMUSP00000156883	ENSMUSP00000098723	Predicted gene, 49909.	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	0.758
Gm49909	Myh10	ENSMUSP00000156883	ENSMUSP00000099671	Predicted gene, 49909.	Myosin-10; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.	0.971
Gm49909	Myh13	ENSMUSP00000156883	ENSMUSP00000104324	Predicted gene, 49909.	Myosin, heavy polypeptide 13, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.707
Gm49909	Myh14	ENSMUSP00000156883	ENSMUSP00000046059	Predicted gene, 49909.	Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.793
Gm49909	Myh7b	ENSMUSP00000156883	ENSMUSP00000090672	Predicted gene, 49909.	Myosin-7B; Involved in muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.747
Gm49909	Myl12a	ENSMUSP00000156883	ENSMUSP00000123412	Predicted gene, 49909.	Myosin, light chain 12A, regulatory, non-sarcomeric.	0.900
Gm49909	Myl12b	ENSMUSP00000156883	ENSMUSP00000042364	Predicted gene, 49909.	Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.	0.901
Gm49909	Myl6	ENSMUSP00000156883	ENSMUSP00000128803	Predicted gene, 49909.	Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium.	0.910
Gm49909	Myl6b	ENSMUSP00000156883	ENSMUSP00000026428	Predicted gene, 49909.	Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium.	0.823
Limch1	Gm49909	ENSMUSP00000098723	ENSMUSP00000156883	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Predicted gene, 49909.	0.758
Limch1	Myh10	ENSMUSP00000098723	ENSMUSP00000099671	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Myosin-10; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.	0.749
Limch1	Myh13	ENSMUSP00000098723	ENSMUSP00000104324	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Myosin, heavy polypeptide 13, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.550
Limch1	Myh14	ENSMUSP00000098723	ENSMUSP00000046059	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.775
Limch1	Myh7b	ENSMUSP00000098723	ENSMUSP00000090672	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Myosin-7B; Involved in muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.550
Limch1	Myl12a	ENSMUSP00000098723	ENSMUSP00000123412	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Myosin, light chain 12A, regulatory, non-sarcomeric.	0.758
Limch1	Myl12b	ENSMUSP00000098723	ENSMUSP00000042364	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.	0.750
Limch1	Myl6	ENSMUSP00000098723	ENSMUSP00000128803	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium.	0.626
Limch1	Myl6b	ENSMUSP00000098723	ENSMUSP00000026428	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium.	0.585
Myh10	Gm49909	ENSMUSP00000099671	ENSMUSP00000156883	Myosin-10; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.	Predicted gene, 49909.	0.971
Myh10	Limch1	ENSMUSP00000099671	ENSMUSP00000098723	Myosin-10; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.	LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family.	0.749