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Ppfia3 Ppfia3 Syngr1 Syngr1 Doc2b Doc2b Mlph Mlph Syt13 Syt13 Syt10 Syt10 Unc13a Unc13a Sytl1 Sytl1 Pclo Pclo Sytl4 Sytl4 Bsn Bsn Rep15 Rep15 Kazn Kazn Ptprf Ptprf Syde1 Syde1 Stx11 Stx11 Tspoap1 Tspoap1 Rims2 Rims2 Scgb2b24 Scgb2b24 Ccn3 Ccn3 Syt12 Syt12 Stx19 Stx19 Camk2n2 Camk2n2 Exph5 Exph5 Sytl5 Sytl5 Synpr Synpr Rims3 Rims3 Unc13d Unc13d Rph3a Rph3a Syt17 Syt17 Tmem181a Tmem181a Erc2 Erc2 Syt6 Syt6 Sytl3 Sytl3 Rims1 Rims1 Ppfibp2 Ppfibp2 Rab3b Rab3b Unc13b Unc13b Rab3a Rab3a Lyst Lyst Ppfibp1 Ppfibp1 Syt3 Syt3 Rab3d Rab3d Syn3 Syn3 Rph3al Rph3al Rab27b Rab27b Myo5a Myo5a Stxbp2 Stxbp2 Ppfia4 Ppfia4 Rab3c Rab3c Nim1k Nim1k Tbc1d10a Tbc1d10a Ppfia1 Ppfia1 Unc13c Unc13c Erc1 Erc1 Rab27a Rab27a Sytl2 Sytl2 Rimbp2 Rimbp2 Gm49358 Gm49358 Ppfia2 Ppfia2 Syt16 Syt16 Syt7 Syt7 6330411D24Rik 6330411D24Rik
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Ppfia3Liprin-alpha-3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Belongs to the liprin family. Liprin-alpha subfamily. (1194 aa)
Syngr1Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity. Belongs to the synaptogyrin family. (234 aa)
Doc2bDouble C2-like domain-containing protein beta; Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium- dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium- triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma memb [...] (412 aa)
MlphMelanophilin; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. (590 aa)
Syt13Synaptotagmin-13; May be involved in transport vesicle docking to the plasma membrane. (426 aa)
Syt10Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)- dependent synaptic vesicle exocytosis. Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). (523 aa)
Unc13aProtein unc-13 homolog A; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA- mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in [...] (1712 aa)
Sytl1Synaptotagmin-like protein 1; Binds phosphatidylinositol 3,4,5-trisphosphate (By similarity). May play a role in vesicle trafficking. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes. (568 aa)
PcloProtein piccolo; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well [...] (5068 aa)
Sytl4Synaptotagmin-like protein 4; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner. (673 aa)
BsnProtein bassoon; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in [...] (3942 aa)
Rep15Rab15 effector protein; Regulates transferrin receptor recycling from the endocytic recycling compartment. (230 aa)
KaznKazrin; Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. (414 aa)
PtprfReceptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. (1898 aa)
Syde1Rho GTPase-activating protein SYDE1; GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1. (737 aa)
Stx11Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. (287 aa)
Tspoap1Peripheral-type benzodiazepine receptor-associated protein 1; Belongs to the RIMBP family. (1846 aa)
Rims2Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity). (1572 aa)
Scgb2b24Secretoglobin family 2B member 24; Belongs to the secretoglobin family. (112 aa)
Ccn3CCN family member 3; Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5 [...] (354 aa)
Syt12Synaptotagmin-12; Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus. (421 aa)
Stx19Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR). (292 aa)
Camk2n2Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2 (By similarity). Belongs to the CAMK2N family. (79 aa)
Exph5Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. (1960 aa)
Sytl5Synaptotagmin-like protein 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids (By similarity). (753 aa)
SynprSynaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity). (285 aa)
Rims3Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis. (307 aa)
Unc13dProtein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. (1083 aa)
Rph3aRabphilin-3A; Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity). (681 aa)
Syt17Synaptotagmin-17; Plays a role in dendrite formation by melanocytes. Belongs to the synaptotagmin family. (470 aa)
Tmem181aTransmembrane protein 181A. (474 aa)
Erc2ERC protein 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. (1002 aa)
Syt6Synaptotagmin-6; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm ; Belongs to the synaptotagmin family. (511 aa)
Sytl3Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions. (607 aa)
Rims1Regulating synaptic membrane exocytosis protein 1; Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes (By similarity). (1424 aa)
Ppfibp2Liprin-beta-2; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity). (904 aa)
Rab3bRas-related protein Rab-3B; Protein transport. Probably involved in vesicular traffic (By similarity). (219 aa)
Unc13bProtein unc-13 homolog B; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and [...] (1602 aa)
Rab3aRas-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimula [...] (220 aa)
LystLysosomal-trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules. (3787 aa)
Ppfibp1Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity). Belongs to the liprin family. Liprin-beta subfamily. (980 aa)
Syt3Synaptotagmin-3; Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis. Plays a role in dendrite formation by melanocytes. (587 aa)
Rab3dRas-related protein Rab-3D; Protein transport. Probably involved in vesicular traffic (By similarity). May be involved in the insulin-induced exocytosis of glut4-containing vesicles in adipocytes. (219 aa)
Syn3Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity); Belongs to the synapsin family. (579 aa)
Rph3alRab effector Noc2; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells. (302 aa)
Rab27bRas-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). (218 aa)
Myo5aUnconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1853 aa)
Stxbp2Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity). (593 aa)
Ppfia4Liprin-alpha 4. (1187 aa)
Rab3cRas-related protein Rab-3C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (227 aa)
Nim1kSerine/threonine-protein kinase NIM1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (436 aa)
Tbc1d10aTBC1 domain family member 10A; Acts as GTPase-activating protein for RAB27A. (500 aa)
Ppfia1Ppfia1 protein. (1266 aa)
Unc13cProtein unc-13 homolog C; May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses; Belongs to the unc-13 family. (2210 aa)
Erc1ELKS/Rab6-interacting/CAST family member 1; Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. (1120 aa)
Rab27aRas-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa)
Sytl2Synaptotagmin-like protein 2; Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. Required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology. Isoform 1 acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. Mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mu [...] (950 aa)
Rimbp2RIMS-binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. (1079 aa)
Gm49358Predicted gene, 49358. (418 aa)
Ppfia2Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines; Belongs to the liprin family. Liprin-alpha subfamily. (1257 aa)
Syt16Synaptotagmin-16; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. (549 aa)
Syt7Synaptotagmin-7. (567 aa)
6330411D24RikRIKEN cDNA 6330411D24 gene. (83 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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