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Ear14 Ear14 Defb11 Defb11 Defb1 Defb1 Ltf Ltf Apoa4 Apoa4 Pla2g1b Pla2g1b H2bc4 H2bc4 Defb2 Defb2 Il4 Il4 Nod2 Nod2 Rpl39 Rpl39 Camp Camp AY761185 AY761185 Defa41 Defa41 Defa42 Defa42 Defa43 Defa43 Ear1 Ear1 Defa23 Defa23 Defa30 Defa30 Defa31 Defa31 Defa40 Defa40 Defa3 Defa3 Defa29 Defa29 Defa28 Defa28 Defa25 Defa25 Defa36 Defa36 Defa20 Defa20 Defa32 Defa32 Defa37 Defa37 Bpifb1 Bpifb1 Defa24 Defa24 Defa17 Defa17 H2bc8 H2bc8 Defa35 Defa35 Defa38 Defa38 Defa21 Defa21 Rnase2b Rnase2b Defb39 Defb39 Defa34 Defa34 Ear2 Ear2 Defa26 Defa26 Defa39 Defa39 Defb38 Defb38 Defb37 Defb37 Defb40 Defb40 Defb10 Defb10 H2bc6 H2bc6 Rnase2a Rnase2a Defb9 Defb9 Fau Fau Ear6 Ear6 Defa27 Defa27 Ear10 Ear10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ear14Non-secretory ribonuclease; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities. (155 aa)
Defb11Beta-defensin 11; Has antibacterial activity. (77 aa)
Defb1Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. (69 aa)
LtfLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (707 aa)
Apoa4Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. (395 aa)
Pla2g1bPhospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family. (146 aa)
H2bc4Histone H2B type 1-C/E/G; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
Defb2Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family. (71 aa)
Il4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Belongs to the IL- [...] (140 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1013 aa)
Rpl3960S ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
CampCathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide. (172 aa)
AY761185cDNA sequence AY761185. (94 aa)
Defa41Defensin, alpha, 41. (93 aa)
Defa42Defensin, alpha, 42. (116 aa)
Defa43Defensin, alpha, 42. (116 aa)
Ear1Eosinophil cationic protein 1; Cytotoxin and helminthotoxin with ribonuclease activity. Possesses a wide variety of biological activities (By similarity). Belongs to the pancreatic ribonuclease family. (155 aa)
Defa23Defensin, alpha, 23. (93 aa)
Defa30Defensin, alpha, 30. (93 aa)
Defa31Alpha-defensin 23; May have microbicidal activities; Belongs to the alpha-defensin family. (93 aa)
Defa40Defensin, alpha, 40. (93 aa)
Defa3Defensin, alpha, 3. (93 aa)
Defa29Alpha-defensin-related sequence 1; Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities; Belongs to the alpha-defensin family. (116 aa)
Defa28Defensin, alpha, 28. (94 aa)
Defa25Alpha-defensin 25; May have microbicidal activities; Belongs to the alpha-defensin family. (92 aa)
Defa36Defensin, alpha, 36. (93 aa)
Defa20Defensin, alpha, 20. (95 aa)
Defa32Alpha-defensin 20; May have microbicidal activities; Belongs to the alpha-defensin family. (95 aa)
Defa37Defensin, alpha, 36. (93 aa)
Bpifb1BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. May be involved in formation of the left-right axis in the node of the developing embryo. (474 aa)
Defa24Alpha-defensin 24; May have microbicidal activities; Belongs to the alpha-defensin family. (93 aa)
Defa17Alpha-defensin 3; Probably contributes to the antimicrobial barrier function of the small bowel mucosa. (93 aa)
H2bc8H2B clustered histone 8. (126 aa)
Defa35Alpha-defensin 5; Probably contributes to the antimicrobial barrier function of the small bowel mucosa; Belongs to the alpha-defensin family. (93 aa)
Defa38Defensin, alpha, 38. (116 aa)
Defa21Alpha-defensin 21; May have microbicidal activities; Belongs to the alpha-defensin family. (93 aa)
Rnase2bRibonuclease 2B; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities. (155 aa)
Defb39Beta-defensin 39; Has antibacterial activity. (74 aa)
Defa34Defensin, alpha, 34. (93 aa)
Ear2Eosinophil cationic protein 2; Cytotoxin and helminthotoxin with ribonuclease activity. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. (156 aa)
Defa26Alpha-defensin 26; May have microbicidal activities; Belongs to the alpha-defensin family. (93 aa)
Defa39Defensin, alpha, 39. (116 aa)
Defb38Beta-defensin 38; Synthetic Defb38 kills both Gram-negative (E.coli and P.aeruginosa) and Gram-positive (E.faecium) bacteria. (63 aa)
Defb37Beta-defensin 37; Has antibacterial activity. (62 aa)
Defb40Beta-defensin 40; Has antibacterial activity. (73 aa)
Defb10Beta-defensin 10; Has antibacterial activity. (73 aa)
H2bc6H2B clustered histone 6. (126 aa)
Rnase2aRibonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin); Belongs to the pancreatic ribonuclease family. (155 aa)
Defb9Beta-defensin 9; Has antibacterial activity. (67 aa)
FauUbiquitin-like protein FUBI; Belongs to the ubiquitin family. (133 aa)
Ear6Eosinophil-associated, ribonuclease A family, member 6; Belongs to the pancreatic ribonuclease family. (155 aa)
Defa27Defensin, alpha, 27. (93 aa)
Ear10Eosinophil-associated, ribonuclease A family, member 10; Belongs to the pancreatic ribonuclease family. (156 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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