STRINGSTRING
Ep400 Ep400 H2-M9 H2-M9 Igll1 Igll1 Itga4 Itga4 H2-T3 H2-T3 H2-T23 H2-T23 Abo Abo Iglc2 Iglc2 Klrc2 Klrc2 Klrd1 Klrd1 Hnrnpm Hnrnpm Sirpa Sirpa Lck Lck Tap1 Tap1 H2-M2 H2-M2 Maml1 Maml1 H2-M10.4 H2-M10.4 H2-Eb2 H2-Eb2 H2-M10.5 H2-M10.5 H2-M5 H2-M5 Tapbpl Tapbpl H2-Eb1 H2-Eb1 Psap Psap Ighv6-4 Ighv6-4 Ighv6-5 Ighv6-5 H2-D1 H2-D1 H2-Q6 H2-Q6 H2-Q10 H2-Q10 Topors Topors H2-Aa H2-Aa Spon2 Spon2 H2-Ab1 H2-Ab1 H2-M1 H2-M1 H2-M10.6 H2-M10.6 Mfap4 Mfap4 Dhcr24 Dhcr24 H2-M3 H2-M3 Gp2 Gp2 Slc7a9 Slc7a9 Klrc1 Klrc1 Cd1d1 Cd1d1 Fcna Fcna Fcnb Fcnb Tspan4 Tspan4 H2-M10.1 H2-M10.1 Tap2 Tap2 H2-K1 H2-K1 Tapbp Tapbp H2-M10.2 H2-M10.2 Ppp2ca Ppp2ca Cd40 Cd40 Plg Plg Ppp2r1a Ppp2r1a Tgfb1 Tgfb1 Cd48 Cd48 Klrc3 Klrc3 H2-Q7 H2-Q7 H2-Q1 H2-Q1 H2-M10.3 H2-M10.3 H2-Q2 H2-Q2 H2-T22 H2-T22 H2-Q4 H2-Q4 Jchain Jchain
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Ep400E1A-binding protein p400; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the associ [...] (3035 aa)
H2-M9Histocompatibility 2, M region locus 9; Belongs to the MHC class I family. (342 aa)
Igll1Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development. (209 aa)
Itga4Integrin alpha-4; Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-ce [...] (1032 aa)
H2-T3H-2 class I histocompatibility antigen, TLA(B) alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (384 aa)
H2-T23H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system. (357 aa)
AboHisto-blood group ABO system transferase. (332 aa)
Iglc2Ig lambda-2 chain C region. (104 aa)
Klrc2Killer cell lectin-like receptor subfamily C, member 2. (238 aa)
Klrd1Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)
HnrnpmHeterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (By similarity). (729 aa)
SirpaTyrosine-protein phosphatase non-receptor type substrate 1; Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative re [...] (513 aa)
LckProto-oncogene tyrosine-protein kinase LCK; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associa [...] (520 aa)
Tap1Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. (724 aa)
H2-M2Histocompatibility 2, M region locus 2; Belongs to the MHC class I family. (343 aa)
Maml1Mastermind-like protein 1; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. (1020 aa)
H2-M10.4Histocompatibility 2, M region locus 10.4; Belongs to the MHC class I family. (331 aa)
H2-Eb2Histocompatibility 2, class II antigen E beta2. (287 aa)
H2-M10.5Histocompatibility 2, M region locus 10.5; Belongs to the MHC class I family. (330 aa)
H2-M5Histocompatibility 2, M region locus 5; Belongs to the MHC class I family. (348 aa)
TapbplTapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. (451 aa)
H2-Eb1H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family. (264 aa)
PsapSaposin-B-Val; [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposins are specific low-mol [...] (557 aa)
Ighv6-4Immunoglobulin heavy variable V6-4. (99 aa)
Ighv6-5Ig heavy chain V-III region J606. (99 aa)
H2-D1H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (362 aa)
H2-Q6H-2 class I histocompatibility antigen, Q8 alpha chain; Involved in the presentation of foreign antigens to the immune system. (326 aa)
H2-Q10H-2 class I histocompatibility antigen, Q10 alpha chain; Involved in the presentation of foreign antigens to the immune system. (325 aa)
ToporsE3 ubiquitin-protein ligase Topors; Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation. (1033 aa)
H2-AaH-2 class II histocompatibility antigen, A-B alpha chain. (256 aa)
Spon2Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Binds bacterial lipopolysaccharide. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens. (330 aa)
H2-Ab1H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family. (265 aa)
H2-M1Histocompatibility 2, M region locus 1; Belongs to the MHC class I family. (344 aa)
H2-M10.6Major histocompatibility complex class Ib M10.8; Belongs to the MHC class I family. (330 aa)
Mfap4Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. (281 aa)
Dhcr24Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (By similarity). (516 aa)
H2-M3Histocompatibility 2, M region locus 3; Belongs to the MHC class I family. (336 aa)
Gp2Pancreatic secretory granule membrane major glycoprotein GP2. (534 aa)
Slc7a9B(0,+)-type amino acid transporter 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney proximal tubule. Belongs to the amino acid-polyamine-organocation (APC) superfamily. (487 aa)
Klrc1Killer cell lectin-like receptor subfamily C, member 1. (244 aa)
Cd1d1Antigen-presenting glycoprotein CD1d1; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. (336 aa)
FcnaFicolin-1; Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen- associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity). (334 aa)
FcnbFicolin-2; May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity); Belongs to the ficolin lectin family. (314 aa)
Tspan4Tetraspanin-4; Belongs to the tetraspanin (TM4SF) family. (238 aa)
H2-M10.1Histocompatibility 2, M region locus 10.1; Belongs to the MHC class I family. (331 aa)
Tap2Antigen peptide transporter 2; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. (702 aa)
H2-K1H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (369 aa)
TapbpTapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). (466 aa)
H2-M10.2Histocompatibility 2, M region locus 10.2; Belongs to the MHC class I family. (329 aa)
Ppp2caSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
Cd40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. (289 aa)
PlgPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (812 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). (589 aa)
Tgfb1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration. Activation into mature form follows different [...] (390 aa)
Cd48CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. (240 aa)
Klrc3Killer cell lectin-like receptor subfamily C, member 3. (221 aa)
H2-Q7H-2 class I histocompatibility antigen, Q7 alpha chain; Involved in the presentation of foreign antigens to the immune system. (334 aa)
H2-Q1Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family. (368 aa)
H2-M10.3Major histocompatibility complex class Ib M10.3; Belongs to the MHC class I family. (330 aa)
H2-Q2Histocompatibility 2, Q region locus 2; Belongs to the MHC class I family. (360 aa)
H2-T22Histocompatibility 2, T region locus 22; Belongs to the MHC class I family. (379 aa)
H2-Q4Histocompatibility 2, Q region locus 4; Belongs to the MHC class I family. (354 aa)
JchainImmunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. (159 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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