STRINGSTRING
Cfap53 Cfap53 Cfap161 Cfap161 4930404N11Rik 4930404N11Rik Tekt1 Tekt1 Cfap52 Cfap52 Ribc2 Ribc2 Efhb Efhb Tekt4 Tekt4 Efhc2 Efhc2 Cfap126 Cfap126 Enkur Enkur 1700013F07Rik 1700013F07Rik 1700094D03Rik 1700094D03Rik Saxo1 Saxo1 1700012P22Rik 1700012P22Rik Cfap20 Cfap20 Mns1 Mns1 Tekt3 Tekt3 Efhc1 Efhc1 Rpgrip1l Rpgrip1l Pacrg Pacrg 1700028P14Rik 1700028P14Rik Saxo2 Saxo2 Fam166b Fam166b Spag8 Spag8 Cfap45 Cfap45 1700007K13Rik 1700007K13Rik Cep162 Cep162 Ccdc173 Ccdc173 Arfgef2 Arfgef2 Arl6 Arl6 Ttc30a1 Ttc30a1 Ttc30a2 Ttc30a2 Ttc30b Ttc30b Tekt2 Tekt2 Ccpg1os Ccpg1os Nme7 Nme7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cfap53Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. (514 aa)
Cfap161Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. (303 aa)
4930404N11RikUncharacterized protein C19orf71 homolog. (206 aa)
Tekt1Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). (418 aa)
Cfap52Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. (620 aa)
Ribc2RIB43A-like with coiled-coils protein 2; Belongs to the RIB43A family. (377 aa)
EfhbEF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. (853 aa)
Tekt4Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility. (447 aa)
Efhc2EF-hand domain-containing family member C2. (750 aa)
Cfap126Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear; Belongs to the Flattop family. (189 aa)
EnkurEnkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. (255 aa)
1700013F07RikProtein C1orf194 homolog; May play an important role for the maintenance of myelin-axon integrity. May affect intracellular Ca(2+) homeostasis (By similarity). (168 aa)
1700094D03RikUncharacterized protein C1orf189 homolog. (106 aa)
Saxo1Stabilizer of axonemal microtubules 1. (476 aa)
1700012P22RikUncharacterized protein C1orf158 homolog. (196 aa)
Cfap20Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). (193 aa)
Mns1Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. (491 aa)
Tekt3Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility; Belongs to the tektin family. (490 aa)
Efhc1EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death. Overexpression of EFHC1 in hippocampal primary culture neurons induced apoptosis. (648 aa)
Rpgrip1lProtein fantom; Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of dis [...] (1264 aa)
PacrgParkin coregulated gene protein homolog; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity). (241 aa)
1700028P14RikProtein C9orf135 homolog. (228 aa)
Saxo2Stabilizer of axonemal microtubules 2; Belongs to the FAM154 family. (394 aa)
Fam166bProtein FAM166B. (379 aa)
Spag8Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). (470 aa)
Cfap45Cilia and flagella-associated protein 45. (551 aa)
1700007K13RikUPF0691 protein C9orf116 homolog. (167 aa)
Cep162Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity). (1403 aa)
Ccdc173Coiled-coil domain-containing protein 173. (547 aa)
Arfgef2Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...] (1792 aa)
Arl6ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle (By similarity). Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (By similarity). May regulate cilia assembl [...] (193 aa)
Ttc30a1Tetratricopeptide repeat protein 30A1; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (664 aa)
Ttc30a2Tetratricopeptide repeat protein 30A2; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (664 aa)
Ttc30bTetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (664 aa)
Tekt2Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Belongs to the tektin family. (430 aa)
Ccpg1osCell cycle progression 1, opposite strand. (122 aa)
Nme7Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (395 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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