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Slc19a1 | Reduced folate transporter; Transporter that mediates the import of reduced folates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (By similarity). 5-amino-4- imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity). (512 aa) | ||||
Slc46a1 | Proton-coupled folate transporter; Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. (459 aa) |