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Ddx3x Ddx3x Mcts1 Mcts1 Rps11 Rps11 Rps18 Rps18 Mrps18c Mrps18c Rack1 Rack1 Mrps23 Mrps23 Mrps18a Mrps18a Mrps18b Mrps18b Rps26 Rps26 Mrps5 Mrps5 Eif2a Eif2a Rps3a1 Rps3a1 Mrps15 Mrps15 Mrps33 Mrps33 Mrps11 Mrps11 Rps3 Rps3 Rps4x Rps4x Mrps31 Mrps31 Mrps22 Mrps22 Rpsa Rpsa Dhx29 Dhx29 D1Pas1 D1Pas1 Mrps2 Mrps2 Mrps6 Mrps6 Mrps28 Mrps28 Rps29 Rps29 Mrps34 Mrps34 Mrps35 Mrps35 Mrps7 Mrps7 Rps23 Rps23 Mrps16 Mrps16 Mrps9 Mrps9 Rps21 Rps21 Rps27rt Rps27rt Mrps27 Mrps27 Eif2d Eif2d Mrps21 Mrps21 Rps15 Rps15 Chchd1 Chchd1 Rps7 Rps7 Npm1 Npm1 Mrpl42 Mrpl42 Rps25 Rps25 Rps17 Rps17 Ptcd3 Ptcd3 Aurkaip1 Aurkaip1 Isg15 Isg15 B3galt4 B3galt4 Gm11808 Gm11808 Dap3 Dap3 Hba-a2 Hba-a2 Rps2 Rps2 Larp4 Larp4 Rps8 Rps8 Rps6 Rps6 Rps27a Rps27a Mcts2 Mcts2 Rps16 Rps16 Rps19 Rps19 Rps5 Rps5 Rps9 Rps9 Rps10 Rps10 Mrps17 Mrps17 Mrps10 Mrps10 Mrps25 Mrps25 Mrps24 Mrps24 Rps15a Rps15a Mrps14 Mrps14 Uba52 Uba52 Rps27l Rps27l Rps20 Rps20 Mrps26 Mrps26 Rps13 Rps13 Gm10260 Gm10260 Rps27 Rps27 Mrps12 Mrps12 Rps28 Rps28 Fau Fau Rps12 Rps12 Rps18-ps5 Rps18-ps5 Rps24 Rps24 Gm49711 Gm49711 Gm49804 Gm49804 Rps14 Rps14
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Ddx3xATP-dependent RNA helicase DDX3X; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in transcription regulation. Positively regulates CDKN1A/WAF1/CIP1 t [...] (662 aa)
Mcts1Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...] (181 aa)
Rps1140S ribosomal protein S11. (158 aa)
Rps1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
Mrps18c28S ribosomal protein S18c, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family. (143 aa)
Rack1Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes a [...] (317 aa)
Mrps2328S ribosomal protein S23, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS23 family. (177 aa)
Mrps18a28S ribosomal protein S18a, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily. (196 aa)
Mrps18b28S ribosomal protein S18b, mitochondrial. (254 aa)
Rps2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
Mrps528S ribosomal protein S5, mitochondrial; Belongs to the universal ribosomal protein uS5 family. (432 aa)
Eif2aEukaryotic translation initiation factor 2A, N-terminally processed; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (581 aa)
Rps3a140S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
Mrps1528S ribosomal protein S15, mitochondrial; Belongs to the universal ribosomal protein uS15 family. (258 aa)
Mrps3328S ribosomal protein S33, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS33 family. (106 aa)
Mrps1128S ribosomal protein S11, mitochondrial; Belongs to the universal ribosomal protein uS11 family. (191 aa)
Rps340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] (243 aa)
Rps4x40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
Mrps3128S ribosomal protein S31, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS31 family. (384 aa)
Mrps2228S ribosomal protein S22, mitochondrial. (359 aa)
Rpsa40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
Dhx29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1365 aa)
D1Pas1Putative ATP-dependent RNA helicase Pl10; Putative ATP-dependent RNA helicase. Possible role in a key step of the spermatogenic process; Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (660 aa)
Mrps228S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation. (291 aa)
Mrps628S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. (125 aa)
Mrps2828S ribosomal protein S28, mitochondrial; Belongs to the bacterial ribosomal protein bS1 family. (186 aa)
Rps2940S ribosomal protein S29. (56 aa)
Mrps3428S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. Belongs to the mitochondrion-specific ribosomal protein mS34 family. (218 aa)
Mrps3528S ribosomal protein S35, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS35 family. (320 aa)
Mrps728S ribosomal protein S7, mitochondrial; Belongs to the universal ribosomal protein uS7 family. (242 aa)
Rps2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
Mrps1628S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family. (135 aa)
Mrps928S ribosomal protein S9, mitochondrial; Belongs to the universal ribosomal protein uS9 family. (390 aa)
Rps2140S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
Rps27rt40S ribosomal protein S27; Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). (84 aa)
Mrps2728S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues. (415 aa)
Eif2dEukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its [...] (570 aa)
Mrps2128S ribosomal protein S21, mitochondrial; Belongs to the bacterial ribosomal protein bS21 family. (87 aa)
Rps1540S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
Chchd1Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; Belongs to the mitochondrion-specific ribosomal protein mS37 family. (118 aa)
Rps740S ribosomal protein S7; Required for rRNA maturation. (194 aa)
Npm1Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. M [...] (292 aa)
Mrpl4239S ribosomal protein L42, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL42 family. (142 aa)
Rps2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (125 aa)
Rps1740S ribosomal protein S17; Belongs to the eukaryotic ribosomal protein eS17 family. (135 aa)
Ptcd3Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation. (685 aa)
Aurkaip1Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation; Belongs to the mitochondrion-specific ribosomal protein mS38 family. (200 aa)
Isg15Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, TRIM25, STAT5A, MAPK1/ERK2 and globin. Can also isgylate: DDX58/RIG-I which inhibits its function in antiviral sign [...] (161 aa)
B3galt4Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis. Belongs to the glycosyltransferase 31 family. (371 aa)
Gm11808Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
Dap328S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death. Belongs to the mitochondrion-specific ribosomal protein mS29 family. (396 aa)
Hba-a2Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
Rps240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (293 aa)
Larp4La-related protein 4; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization. (719 aa)
Rps840S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
Rps640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (249 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Mcts2Malignant T-cell-amplified sequence 2. (181 aa)
Rps1640S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (146 aa)
Rps1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
Rps540S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family. (204 aa)
Rps940S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
Rps1040S ribosomal protein S10; Component of the 40S ribosomal subunit. (165 aa)
Mrps1728S ribosomal protein S17, mitochondrial; Belongs to the universal ribosomal protein uS17 family. (120 aa)
Mrps1028S ribosomal protein S10, mitochondrial; Belongs to the universal ribosomal protein uS10 family. (201 aa)
Mrps2528S ribosomal protein S25, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS25 family. (171 aa)
Mrps2428S ribosomal protein S24, mitochondrial; Belongs to the universal ribosomal protein uS3 family. (167 aa)
Rps15a40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis; Belongs to the universal ribosomal protein uS8 family. (130 aa)
Mrps1428S ribosomal protein S14, mitochondrial; Belongs to the universal ribosomal protein uS14 family. (128 aa)
Uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
Rps27l40S ribosomal protein S27. (105 aa)
Rps2040S ribosomal protein S20. (119 aa)
Mrps2628S ribosomal protein S26, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS26 family. (200 aa)
Rps1340S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (151 aa)
Gm10260Ribosomal protein S18, pseudogene 6; Belongs to the universal ribosomal protein uS13 family. (152 aa)
Rps27Ribosomal protein S27. (84 aa)
Mrps1228S ribosomal protein S12, mitochondrial; Belongs to the universal ribosomal protein uS12 family. (139 aa)
Rps2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
FauUbiquitin-like protein FUBI; Belongs to the ubiquitin family. (133 aa)
Rps1240S ribosomal protein S12. (132 aa)
Rps18-ps5Ribosomal protein S18, pseudogene 5; Belongs to the universal ribosomal protein uS13 family. (152 aa)
Rps2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. (133 aa)
Gm49711Predicted gene, 49711. (117 aa)
Gm49804Predicted gene, 49804. (287 aa)
Rps1440S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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