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Cyp2c39 Cyp2c39 Cyp2c23 Cyp2c23 Cyp2e1 Cyp2e1 Cyp2j5 Cyp2j5 Cyp2j6 Cyp2j6 Cyp2j13 Cyp2j13 Cyp2s1 Cyp2s1 Cyp2c38 Cyp2c38 Cyp2c37 Cyp2c37 Cyp2g1 Cyp2g1 Cyp2c54 Cyp2c54 Cyp2j9 Cyp2j9 Cyp2c70 Cyp2c70 Cyp2c67 Cyp2c67 Cyp2b10 Cyp2b10 Cyp2a12 Cyp2a12 Cyp2b23 Cyp2b23 Cyp2b19 Cyp2b19 Cyp2c50 Cyp2c50 Cyp2b9 Cyp2b9 Cyp2c66 Cyp2c66 Cyp2c65 Cyp2c65 Cyp2a4 Cyp2a4 Cyp2c68 Cyp2c68 Cyp2t4 Cyp2t4 Cyp2a22 Cyp2a22 Cyp2j11 Cyp2j11 Cyp2c69 Cyp2c69 Cyp2j12 Cyp2j12 Cyp2j8 Cyp2j8 Cyp2c40 Cyp2c40 Cyp2f2 Cyp2f2 Cyp2c29 Cyp2c29 Cyp2b13 Cyp2b13 Cyp2a5 Cyp2a5 Cyp2c55 Cyp2c55
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Cyp2c39Cytochrome P450 2C39; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET); Belongs to the cytochrome P450 family. (490 aa)
Cyp2c23Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] (494 aa)
Cyp2e1Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (493 aa)
Cyp2j5Cytochrome P450 2J5. (501 aa)
Cyp2j6Cytochrome P450 2J6. (501 aa)
Cyp2j13Cytochrome P450, family 2, subfamily j, polypeptide 13; Belongs to the cytochrome P450 family. (503 aa)
Cyp2s1Cytochrome P450 2S1; A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HP [...] (501 aa)
Cyp2c38Cytochrome P450 2C38; Metabolizes arachidonic acid to produce 11,12- epoxyeicosatrienoic acid (EET); Belongs to the cytochrome P450 family. (490 aa)
Cyp2c37Cytochrome P450 2C37; Metabolizes arachidonic acid to produce 12- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. (490 aa)
Cyp2g1Cytochrome P450, family 2, subfamily g, polypeptide 1; Belongs to the cytochrome P450 family. (494 aa)
Cyp2c54Cytochrome P450 2C54; Metabolizes arachidonic acid mainly to 12- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. (490 aa)
Cyp2j9Cytochrome P450, family 2, subfamily j, polypeptide 9; Belongs to the cytochrome P450 family. (502 aa)
Cyp2c70Cytochrome P450 2C70; A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis. Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively. May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotei [...] (489 aa)
Cyp2c67Cytochrome P450, family 2, subfamily c, polypeptide 67; Belongs to the cytochrome P450 family. (491 aa)
Cyp2b10Cytochrome P450 2B10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
Cyp2a12Cytochrome P450 2A12; Highly active in the 7-alpha-hydroxylation of testosterone. (492 aa)
Cyp2b23Cytochrome P450, family 2, subfamily b, polypeptide 23; Belongs to the cytochrome P450 family. (491 aa)
Cyp2b19Cytochrome P450 2B19; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (492 aa)
Cyp2c50Cytochrome P450 2C50; Metabolizes arachidonic acid to several midchain and omega- terminal hydroxyeicosatetraenoic acids (HETE). (490 aa)
Cyp2b9Cytochrome P450 2B9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
Cyp2c66Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family. (490 aa)
Cyp2c65Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family. (490 aa)
Cyp2a4Cytochrome P450 2A4; Highly active in the 15-alpha-hydroxylation of testosterone. Also active in the 15-alpha-hydroxylation of progesterone and androstenedione. Little or no activity on corticosterone, pregnenolone, dehydroepiandrosterone, estradiol or estriol; Belongs to the cytochrome P450 family. (494 aa)
Cyp2c68Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. (491 aa)
Cyp2t4Cytochrome P450, family 2, subfamily t, polypeptide 4. (503 aa)
Cyp2a22Cytochrome P450, family 2, subfamily a, polypeptide 22; Belongs to the cytochrome P450 family. (492 aa)
Cyp2j11Cytochrome P450, family 2, subfamily j, polypeptide 11; Belongs to the cytochrome P450 family. (504 aa)
Cyp2c69Cytochrome P450, family 2, subfamily c, polypeptide 69; Belongs to the cytochrome P450 family. (491 aa)
Cyp2j12Cytochrome P450, family 2, subfamily j, polypeptide 12; Belongs to the cytochrome P450 family. (502 aa)
Cyp2j8Cytochrome P450, family 2, subfamily j, polypeptide 8; Belongs to the cytochrome P450 family. (503 aa)
Cyp2c40Cytochrome P450 2C40; A cytochrome P450 monooxygenase that may play a major role in the metabolism of arachidonic acid in the intestinal tract. Exhibits regioselective hydroxylase and epoxidase activity toward arachidonic acid, producing 16(R)- hydroxyeicosatetraenoic acid (HETE) and (14R,15S)-epoxyeicosatrienoic acid (EpETrE) as major products. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). (520 aa)
Cyp2f2Cytochrome P450 2F2; Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung; Belongs to the cytochrome P450 family. (491 aa)
Cyp2c29Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). (490 aa)
Cyp2b13Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family. (491 aa)
Cyp2a5Cytochrome P450 2A5; Exhibits a high coumarin 7-hydroxylase activity. (494 aa)
Cyp2c55Cytochrome P450 2C55; Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. (490 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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