node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aff1 | Aff3 | ENSMUSP00000031256 | ENSMUSP00000092637 | AF4/FMR2 family member 1; Belongs to the AF4 family. | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | 0.624 |
Aff1 | Aff4 | ENSMUSP00000031256 | ENSMUSP00000051479 | AF4/FMR2 family member 1; Belongs to the AF4 family. | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. | 0.995 |
Aff1 | Eaf1 | ENSMUSP00000031256 | ENSMUSP00000022446 | AF4/FMR2 family member 1; Belongs to the AF4 family. | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. | 0.966 |
Aff1 | Eaf2 | ENSMUSP00000031256 | ENSMUSP00000110477 | AF4/FMR2 family member 1; Belongs to the AF4 family. | ELL-associated factor 2; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity; Belongs to the EAF family. | 0.897 |
Aff1 | Mllt1 | ENSMUSP00000031256 | ENSMUSP00000025053 | AF4/FMR2 family member 1; Belongs to the AF4 family. | Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 1. | 0.999 |
Aff1 | Mllt3 | ENSMUSP00000031256 | ENSMUSP00000077232 | AF4/FMR2 family member 1; Belongs to the AF4 family. | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | 0.999 |
Aff3 | Aff1 | ENSMUSP00000092637 | ENSMUSP00000031256 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | AF4/FMR2 family member 1; Belongs to the AF4 family. | 0.624 |
Aff3 | Aff4 | ENSMUSP00000092637 | ENSMUSP00000051479 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. | 0.783 |
Aff3 | Eaf1 | ENSMUSP00000092637 | ENSMUSP00000022446 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. | 0.749 |
Aff3 | Eaf2 | ENSMUSP00000092637 | ENSMUSP00000110477 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | ELL-associated factor 2; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity; Belongs to the EAF family. | 0.605 |
Aff3 | Mllt1 | ENSMUSP00000092637 | ENSMUSP00000025053 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 1. | 0.805 |
Aff3 | Mllt3 | ENSMUSP00000092637 | ENSMUSP00000077232 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | 0.863 |
Aff4 | Aff1 | ENSMUSP00000051479 | ENSMUSP00000031256 | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. | AF4/FMR2 family member 1; Belongs to the AF4 family. | 0.995 |
Aff4 | Aff3 | ENSMUSP00000051479 | ENSMUSP00000092637 | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | 0.783 |
Aff4 | Eaf1 | ENSMUSP00000051479 | ENSMUSP00000022446 | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. | 0.975 |
Aff4 | Eaf2 | ENSMUSP00000051479 | ENSMUSP00000110477 | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. | ELL-associated factor 2; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity; Belongs to the EAF family. | 0.964 |
Aff4 | Mllt1 | ENSMUSP00000051479 | ENSMUSP00000025053 | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. | Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 1. | 0.999 |
Aff4 | Mllt3 | ENSMUSP00000051479 | ENSMUSP00000077232 | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | 0.999 |
Eaf1 | Aff1 | ENSMUSP00000022446 | ENSMUSP00000031256 | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. | AF4/FMR2 family member 1; Belongs to the AF4 family. | 0.966 |
Eaf1 | Aff3 | ENSMUSP00000022446 | ENSMUSP00000092637 | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | 0.749 |