STRINGSTRING
H2-Q7 H2-Q7 H2-M10.4 H2-M10.4 H2-Eb2 H2-Eb2 H2-M10.5 H2-M10.5 H2-M1 H2-M1 H2-M10.6 H2-M10.6 H2-M3 H2-M3 Cd1d1 Cd1d1 H2-Q6 H2-Q6 H2-M10.1 H2-M10.1 H2-K1 H2-K1 H2-M10.2 H2-M10.2 Eps8l1 Eps8l1 H2-M2 H2-M2 H2-M5 H2-M5 H2-Q10 H2-Q10 H2-D1 H2-D1 Mr1 Mr1 H2-T3 H2-T3 H2-Eb1 H2-Eb1 H2-T23 H2-T23 Add1 Add1 Lck Lck Fyn Fyn Dock2 Dock2 H2-M9 H2-M9 H2-Q4 H2-Q4 H2-T22 H2-T22 H2-Q2 H2-Q2 H2-M10.3 H2-M10.3 H2-Q1 H2-Q1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2-Q7H-2 class I histocompatibility antigen, Q7 alpha chain; Involved in the presentation of foreign antigens to the immune system. (334 aa)
H2-M10.4Histocompatibility 2, M region locus 10.4; Belongs to the MHC class I family. (331 aa)
H2-Eb2Histocompatibility 2, class II antigen E beta2. (287 aa)
H2-M10.5Histocompatibility 2, M region locus 10.5; Belongs to the MHC class I family. (330 aa)
H2-M1Histocompatibility 2, M region locus 1; Belongs to the MHC class I family. (344 aa)
H2-M10.6Major histocompatibility complex class Ib M10.8; Belongs to the MHC class I family. (330 aa)
H2-M3Histocompatibility 2, M region locus 3; Belongs to the MHC class I family. (336 aa)
Cd1d1Antigen-presenting glycoprotein CD1d1; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. (336 aa)
H2-Q6H-2 class I histocompatibility antigen, Q8 alpha chain; Involved in the presentation of foreign antigens to the immune system. (326 aa)
H2-M10.1Histocompatibility 2, M region locus 10.1; Belongs to the MHC class I family. (331 aa)
H2-K1H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (369 aa)
H2-M10.2Histocompatibility 2, M region locus 10.2; Belongs to the MHC class I family. (329 aa)
Eps8l1Epidermal growth factor receptor kinase substrate 8-like protein 1; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity); Belongs to the EPS8 family. (716 aa)
H2-M2Histocompatibility 2, M region locus 2; Belongs to the MHC class I family. (343 aa)
H2-M5Histocompatibility 2, M region locus 5; Belongs to the MHC class I family. (348 aa)
H2-Q10H-2 class I histocompatibility antigen, Q10 alpha chain; Involved in the presentation of foreign antigens to the immune system. (325 aa)
H2-D1H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (362 aa)
Mr1Major histocompatibility complex class I-related gene protein; Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites (By similarity). Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. (341 aa)
H2-T3H-2 class I histocompatibility antigen, TLA(B) alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family. (384 aa)
H2-Eb1H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family. (264 aa)
H2-T23H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system. (357 aa)
Add1Alpha-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. (735 aa)
LckProto-oncogene tyrosine-protein kinase LCK; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associa [...] (520 aa)
FynTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
Dock2Dedicator of cytokinesis protein 2; Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. (1828 aa)
H2-M9Histocompatibility 2, M region locus 9; Belongs to the MHC class I family. (342 aa)
H2-Q4Histocompatibility 2, Q region locus 4; Belongs to the MHC class I family. (354 aa)
H2-T22Histocompatibility 2, T region locus 22; Belongs to the MHC class I family. (379 aa)
H2-Q2Histocompatibility 2, Q region locus 2; Belongs to the MHC class I family. (360 aa)
H2-M10.3Major histocompatibility complex class Ib M10.3; Belongs to the MHC class I family. (330 aa)
H2-Q1Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family. (368 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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