(15 nodes) post-mRNA release spliceosomal complex network (Mus musculus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Dhx15	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (By similarity). Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. (795 aa)
	Isy1	Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an in [...] (285 aa)
	Cwf19l2	CWF19-like protein 2. (887 aa)
	Syf2	Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the SYF2 family. (242 aa)
	Crnkl1	Crooked neck-like protein 1; Involved in pre-mRNA splicing process. (690 aa)
	Xab2	Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing; Belongs to the crooked-neck family. (855 aa)
	Cwf19l1	CWF19-like protein 1. (537 aa)
	Ccdc12	Coiled-coil domain-containing protein 12. (166 aa)
	Gm45140	Predicted gene 45140. (118 aa)
	Gcfc2	GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons (By similarity); Belongs to the GCF family. (769 aa)
	Tfip11	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (838 aa)
	Ccdc130	Coiled-coil domain-containing protein 130. (385 aa)
	Gm9833	Myelin expression factor 2. (498 aa)
	Myef2	Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA. (591 aa)
	Hnrnpm	Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (By similarity). (729 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccdc12	Ccdc130	ENSMUSP00000019803	ENSMUSP00000096177	Coiled-coil domain-containing protein 12.	Coiled-coil domain-containing protein 130.	0.543
Ccdc12	Crnkl1	ENSMUSP00000019803	ENSMUSP00000001818	Coiled-coil domain-containing protein 12.	Crooked neck-like protein 1; Involved in pre-mRNA splicing process.	0.972
Ccdc12	Cwf19l1	ENSMUSP00000019803	ENSMUSP00000026218	Coiled-coil domain-containing protein 12.	CWF19-like protein 1.	0.581
Ccdc12	Cwf19l2	ENSMUSP00000019803	ENSMUSP00000027027	Coiled-coil domain-containing protein 12.	CWF19-like protein 2.	0.726
Ccdc12	Dhx15	ENSMUSP00000019803	ENSMUSP00000031061	Coiled-coil domain-containing protein 12.	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (By similarity). Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.	0.568
Ccdc12	Gcfc2	ENSMUSP00000019803	ENSMUSP00000035644	Coiled-coil domain-containing protein 12.	GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons (By similarity); Belongs to the GCF family.	0.540
Ccdc12	Gm45140	ENSMUSP00000019803	ENSMUSP00000145334	Coiled-coil domain-containing protein 12.	Predicted gene 45140.	0.695
Ccdc12	Gm9833	ENSMUSP00000019803	ENSMUSP00000058811	Coiled-coil domain-containing protein 12.	Myelin expression factor 2.	0.628
Ccdc12	Hnrnpm	ENSMUSP00000019803	ENSMUSP00000120115	Coiled-coil domain-containing protein 12.	Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (By similarity).	0.559
Ccdc12	Isy1	ENSMUSP00000019803	ENSMUSP00000086923	Coiled-coil domain-containing protein 12.	Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an in [...]	0.715
Ccdc12	Myef2	ENSMUSP00000019803	ENSMUSP00000123088	Coiled-coil domain-containing protein 12.	Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA.	0.628
Ccdc12	Syf2	ENSMUSP00000019803	ENSMUSP00000030622	Coiled-coil domain-containing protein 12.	Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the SYF2 family.	0.709
Ccdc12	Tfip11	ENSMUSP00000019803	ENSMUSP00000031288	Coiled-coil domain-containing protein 12.	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...]	0.667
Ccdc12	Xab2	ENSMUSP00000019803	ENSMUSP00000019614	Coiled-coil domain-containing protein 12.	Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing; Belongs to the crooked-neck family.	0.681
Ccdc130	Ccdc12	ENSMUSP00000096177	ENSMUSP00000019803	Coiled-coil domain-containing protein 130.	Coiled-coil domain-containing protein 12.	0.543
Ccdc130	Crnkl1	ENSMUSP00000096177	ENSMUSP00000001818	Coiled-coil domain-containing protein 130.	Crooked neck-like protein 1; Involved in pre-mRNA splicing process.	0.568
Ccdc130	Cwf19l1	ENSMUSP00000096177	ENSMUSP00000026218	Coiled-coil domain-containing protein 130.	CWF19-like protein 1.	0.574
Ccdc130	Cwf19l2	ENSMUSP00000096177	ENSMUSP00000027027	Coiled-coil domain-containing protein 130.	CWF19-like protein 2.	0.582
Ccdc130	Dhx15	ENSMUSP00000096177	ENSMUSP00000031061	Coiled-coil domain-containing protein 130.	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (By similarity). Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.	0.540
Ccdc130	Gcfc2	ENSMUSP00000096177	ENSMUSP00000035644	Coiled-coil domain-containing protein 130.	GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons (By similarity); Belongs to the GCF family.	0.572