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Ccne1 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. (408 aa) | ||||
Ccne2 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase. (404 aa) | ||||
Cdk2 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa) |