STRINGSTRING
Bbs2 Bbs2 Cfap65 Cfap65 Cfap58 Cfap58 Meig1 Meig1 Spag16 Spag16 Pla2g3 Pla2g3 Ttc12 Ttc12 Drc7 Drc7 Cfap69 Cfap69 Gk2 Gk2 Akap4 Akap4 Ttll5 Ttll5 Dnah1 Dnah1 Dzip1 Dzip1 Klc3 Klc3 Tbc1d21 Tbc1d21 Spef2 Spef2 Mns1 Mns1 Armc12 Armc12 Cfap54 Cfap54 Cfap47 Cfap47 Cfap221 Cfap221 Armc2 Armc2 Cfap43 Cfap43 Fsip2 Fsip2 Ift88 Ift88 Iqcg Iqcg Neurl1a Neurl1a Cep131 Cep131 Cfap157 Cfap157 Cfap44 Cfap44 Spag6 Spag6 Cfap97d1 Cfap97d1 Ttll1 Ttll1 Tpgs1 Tpgs1 Ube2b Ube2b Spag6l Spag6l Cfap206 Cfap206 Ift81 Ift81 Yif1b Yif1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Bbs2Bardet-Biedl syndrome 2 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...] (721 aa)
Cfap65Cilia- and flagella-associated protein 65; May play a role in sperm motility. Belongs to the CFAP65 family. (1847 aa)
Cfap58Cilia- and flagella-associated protein 58. (873 aa)
Meig1Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family. (88 aa)
Spag16Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia. (639 aa)
Pla2g3Phospholipase A2, group III. (504 aa)
Ttc12Tetratricopeptide repeat protein 12. (704 aa)
Drc7Dynein regulatory complex subunit 7; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. (876 aa)
Cfap69Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways. Required for sperm flagellum assembly and stability. (942 aa)
Gk2Glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family. (554 aa)
Akap4A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility. (849 aa)
Ttll5Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for CCSAP localization to both spindle and cilia microtubules (By similarity). Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity). Belongs to the tubulin--tyrosine ligase family. (1328 aa)
Dnah1Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity). (4250 aa)
Dzip1Zinc finger protein DZIP1; May participate in spermatogenesis via its interaction with DAZL. Has a role in primary cilium formation. Belongs to the DZIP C2H2-type zinc-finger protein family. (852 aa)
Klc3Kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. (508 aa)
Tbc1d21TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. (336 aa)
Spef2Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. (875 aa)
Mns1Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. (491 aa)
Armc12Armadillo repeat-containing protein 12. (340 aa)
Cfap54Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. (3171 aa)
Cfap47Cilia and flagella-associated protein 47. (3184 aa)
Cfap221Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family. (836 aa)
Armc2Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability. (99 aa)
Cfap43Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function; Belongs to the CFAP43 family. (1682 aa)
Fsip2Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis. (6995 aa)
Ift88Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. (825 aa)
IqcgDynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (By similarity). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and f [...] (419 aa)
Neurl1aE3 ubiquitin-protein ligase NEURL1; Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; i [...] (574 aa)
Cep131Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] (1059 aa)
Cfap157Cilia- and flagella-associated protein 157; Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure ; Belongs to the CFAP157 family. (523 aa)
Cfap44Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function; Belongs to the CFAP44 family. (1843 aa)
Spag6Sperm-associated antigen 6. (509 aa)
Cfap97d1Uncharacterized protein CFAP97D1; Belongs to the CFAP97 family. (164 aa)
Ttll1Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. (423 aa)
Tpgs1Tubulin polyglutamylase complex subunit 1; May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum. (303 aa)
Ube2bUbiquitin-conjugating enzyme E2 B; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiqui [...] (152 aa)
Spag6lSperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. (507 aa)
Cfap206Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes. (622 aa)
Ift81Intraflagellar transport protein 81 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. [Isoform CDV-1R]: May play a role in development of the testis and spermatogenesis. (676 aa)
Yif1bProtein YIF1B; Belongs to the YIF1 family. (311 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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