STRINGSTRING
Rps10 Rps10 Mcts1 Mcts1 Ddx3x Ddx3x Rps11 Rps11 Rps18 Rps18 Rps26 Rps26 Rps3a1 Rps3a1 Rps3 Rps3 Rps4x Rps4x Rpsa Rpsa Dhx29 Dhx29 D1Pas1 D1Pas1 Rps29 Rps29 Rps23 Rps23 Rps21 Rps21 Rps27rt Rps27rt Eif2d Eif2d Rps15 Rps15 Rps7 Rps7 Rps25 Rps25 Rps17 Rps17 Hba-a2 Hba-a2 Rps2 Rps2 Larp4 Larp4 Rps8 Rps8 Rps6 Rps6 Rps27a Rps27a Mcts2 Mcts2 Rps16 Rps16 Rps19 Rps19 Rps5 Rps5 Rps9 Rps9 Rps14 Rps14 Rps24 Rps24 Rps12 Rps12 Fau Fau Rps28 Rps28 Rps27 Rps27 Rps13 Rps13 Rps20 Rps20 Rps15a Rps15a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rps1040S ribosomal protein S10; Component of the 40S ribosomal subunit. (165 aa)
Mcts1Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...] (181 aa)
Ddx3xATP-dependent RNA helicase DDX3X; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in transcription regulation. Positively regulates CDKN1A/WAF1/CIP1 t [...] (662 aa)
Rps1140S ribosomal protein S11. (158 aa)
Rps1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
Rps2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
Rps3a140S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
Rps340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] (243 aa)
Rps4x40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
Rpsa40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
Dhx29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1365 aa)
D1Pas1Putative ATP-dependent RNA helicase Pl10; Putative ATP-dependent RNA helicase. Possible role in a key step of the spermatogenic process; Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (660 aa)
Rps2940S ribosomal protein S29. (56 aa)
Rps2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
Rps2140S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
Rps27rt40S ribosomal protein S27; Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). (84 aa)
Eif2dEukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its [...] (570 aa)
Rps1540S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
Rps740S ribosomal protein S7; Required for rRNA maturation. (194 aa)
Rps2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (125 aa)
Rps1740S ribosomal protein S17; Belongs to the eukaryotic ribosomal protein eS17 family. (135 aa)
Hba-a2Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
Rps240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (293 aa)
Larp4La-related protein 4; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization. (719 aa)
Rps840S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
Rps640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (249 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Mcts2Malignant T-cell-amplified sequence 2. (181 aa)
Rps1640S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (146 aa)
Rps1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
Rps540S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family. (204 aa)
Rps940S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
Rps1440S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
Rps2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. (133 aa)
Rps1240S ribosomal protein S12. (132 aa)
FauUbiquitin-like protein FUBI; Belongs to the ubiquitin family. (133 aa)
Rps2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
Rps27Ribosomal protein S27. (84 aa)
Rps1340S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (151 aa)
Rps2040S ribosomal protein S20. (119 aa)
Rps15a40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis; Belongs to the universal ribosomal protein uS8 family. (130 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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