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Bop1 Bop1 Prkdc Prkdc Riok2 Riok2 Bysl Bysl Riok3 Riok3 Wdr12 Wdr12 Imp4 Imp4 Xrcc5 Xrcc5 Eif6 Eif6 Rpf1 Rpf1 Nol6 Nol6 Ebna1bp2 Ebna1bp2 Utp11 Utp11 Bms1 Bms1 Mphosph10 Mphosph10 Mak16 Mak16 Nip7 Nip7 Imp3 Imp3 Nol10 Nol10 Fbl Fbl Rrp15 Rrp15 Emg1 Emg1 Utp20 Utp20 Noc4l Noc4l Nop14 Nop14 Rrp9 Rrp9 Tsr1 Tsr1 Pwp2 Pwp2 Utp6 Utp6 Rrp7a Rrp7a Utp4 Utp4 Utp14b Utp14b Wdr36 Wdr36 Rrp1 Rrp1 Wdr3 Wdr3 Utp18 Utp18 Rrs1 Rrs1 Pdcd11 Pdcd11 Nsa2 Nsa2 Utp14a Utp14a Rrp1b Rrp1b Utp25 Utp25 Utp3 Utp3 Snu13 Snu13 Nop56 Nop56 Mrto4 Mrto4 Pin4 Pin4 Utp23 Utp23 Krr1 Krr1 Noc2l Noc2l Nop58 Nop58 Casp8 Casp8 Gtpbp4 Gtpbp4 Ltv1 Ltv1 Pes1 Pes1 Riok1 Riok1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Bop1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (732 aa)
PrkdcDNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (By similarity). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). Must be bound to DNA to express its catalytic properties (By similarity). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (By similarity). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step [...] (4128 aa)
Riok2Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. (547 aa)
ByslBystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. (436 aa)
Riok3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of [...] (519 aa)
Wdr12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
Imp4U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). (291 aa)
Xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (732 aa)
Eif6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
Rpf1Ribosome production factor 1; May be required for ribosome biogenesis. (349 aa)
Nol6Nucleolar protein 6; Belongs to the NRAP family. (1152 aa)
Ebna1bp2Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. (306 aa)
Utp11Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (253 aa)
Bms1BMS1 homolog, ribosome assembly protein (Yeast). (1284 aa)
Mphosph10U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity); Belongs to the MPP10 family. (681 aa)
Mak16Protein MAK16 homolog. (296 aa)
Nip760S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. (180 aa)
Imp3U3 small nucleolar ribonucleoprotein protein IMP3; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). (184 aa)
Nol10Nucleolar protein 10. (687 aa)
FblrRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone [...] (327 aa)
Rrp15RRP15-like protein. (281 aa)
Emg1Ribosomal RNA small subunit methyltransferase NEP1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribos [...] (244 aa)
Utp20Small subunit processome component 20 homolog; Involved in 18S pre-rRNA processing. Associates with U3 snoRNA (By similarity). (2789 aa)
Noc4lNucleolar complex protein 4 homolog. (516 aa)
Nop14Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (860 aa)
Rrp9U3 small nucleolar RNA-interacting protein 2; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). (475 aa)
Tsr1Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. (803 aa)
Pwp2Periodic tryptophan protein 2 homolog. (919 aa)
Utp6U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the UTP6 family. (597 aa)
Rrp7aRibosomal RNA-processing protein 7 homolog A; Belongs to the RRP7 family. (280 aa)
Utp4U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre- ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1. (686 aa)
Utp14bU3 small nucleolar RNA-associated protein 14 homolog B; Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis; Belongs to the UTP14 family. (780 aa)
Wdr36WD repeat domain 36. (899 aa)
Rrp1Ribosomal RNA processing protein 1 homolog A; Plays a critical role in the generation of 28S rRNA. (494 aa)
Wdr3WD repeat-containing protein 3. (942 aa)
Utp18U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family. (552 aa)
Rrs1Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. (365 aa)
Pdcd11Protein RRP5 homolog; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity). (1862 aa)
Nsa2Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (260 aa)
Utp14aU3 small nucleolar RNA-associated protein 14 homolog A; May be required for ribosome biogenesis; Belongs to the UTP14 family. (767 aa)
Rrp1bRibosomal RNA processing protein 1 homolog B; Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (By similarity). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (By similarity). Involved in regulation of mRNA splicing. Inhibits SIPA1 GTPase activity. Involved in regulating expression of extracellular matrix genes. Associates with chromatin and may play a role in modulating chromatin structure (By similarity). B [...] (724 aa)
Utp25Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs; Belongs to the def family. (768 aa)
Utp3Something about silencing protein 10; Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain. Belongs to the SAS10 family. (469 aa)
Snu13NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. (128 aa)
Nop56Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Belongs to the NOP5/NOP56 family. (580 aa)
Mrto4mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa)
Pin4Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity). (131 aa)
Utp23rRNA-processing protein UTP23 homolog; Involved in rRNA-processing and ribosome biogenesis. Belongs to the UTP23/FCF1 family. UTP23 subfamily. (249 aa)
Krr1KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). (380 aa)
Noc2lNucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). (750 aa)
Nop58Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity). Belongs to the NOP5/NOP56 family. (536 aa)
Casp8Caspase-8 subunit p10; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CA [...] (500 aa)
Gtpbp4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. (634 aa)
Ltv1Protein LTV1 homolog; Belongs to the LTV1 family. (470 aa)
Pes1Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (584 aa)
Riok1Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...] (567 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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