11 items (mouse) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Edges represent protein-protein associations

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	Nsa2	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (260 aa)
	Ltv1	Protein LTV1 homolog; Belongs to the LTV1 family. (470 aa)
	Riok1	Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...] (567 aa)
	Riok2	Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. (547 aa)
	Bysl	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. (436 aa)
	Riok3	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of [...] (519 aa)
	Wdr12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
	Noc4l	Nucleolar complex protein 4 homolog. (516 aa)
	Nop14	Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (860 aa)
	Tsr1	Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. (803 aa)
	Gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. (634 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bysl	Gtpbp4	ENSMUSP00000024783	ENSMUSP00000152412	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	0.916
Bysl	Ltv1	ENSMUSP00000024783	ENSMUSP00000019950	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Protein LTV1 homolog; Belongs to the LTV1 family.	0.999
Bysl	Noc4l	ENSMUSP00000024783	ENSMUSP00000038263	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Nucleolar complex protein 4 homolog.	0.999
Bysl	Nop14	ENSMUSP00000024783	ENSMUSP00000038382	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).	0.999
Bysl	Nsa2	ENSMUSP00000024783	ENSMUSP00000073161	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).	0.759
Bysl	Riok1	ENSMUSP00000024783	ENSMUSP00000021866	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...]	0.904
Bysl	Riok2	ENSMUSP00000024783	ENSMUSP00000024620	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function.	0.997
Bysl	Riok3	ENSMUSP00000024783	ENSMUSP00000025270	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of [...]	0.818
Bysl	Tsr1	ENSMUSP00000024783	ENSMUSP00000039027	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus.	0.999
Bysl	Wdr12	ENSMUSP00000024783	ENSMUSP00000027173	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.848
Gtpbp4	Bysl	ENSMUSP00000152412	ENSMUSP00000024783	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.	0.916
Gtpbp4	Ltv1	ENSMUSP00000152412	ENSMUSP00000019950	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Protein LTV1 homolog; Belongs to the LTV1 family.	0.962
Gtpbp4	Noc4l	ENSMUSP00000152412	ENSMUSP00000038263	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Nucleolar complex protein 4 homolog.	0.803
Gtpbp4	Nop14	ENSMUSP00000152412	ENSMUSP00000038382	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).	0.951
Gtpbp4	Nsa2	ENSMUSP00000152412	ENSMUSP00000073161	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).	0.999
Gtpbp4	Riok1	ENSMUSP00000152412	ENSMUSP00000021866	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...]	0.710
Gtpbp4	Riok2	ENSMUSP00000152412	ENSMUSP00000024620	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function.	0.752
Gtpbp4	Riok3	ENSMUSP00000152412	ENSMUSP00000025270	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of [...]	0.500
Gtpbp4	Tsr1	ENSMUSP00000152412	ENSMUSP00000039027	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus.	0.918
Gtpbp4	Wdr12	ENSMUSP00000152412	ENSMUSP00000027173	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.996