node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bysl | Gtpbp4 | ENSMUSP00000024783 | ENSMUSP00000152412 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 0.916 |
Bysl | Ltv1 | ENSMUSP00000024783 | ENSMUSP00000019950 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Protein LTV1 homolog; Belongs to the LTV1 family. | 0.999 |
Bysl | Noc4l | ENSMUSP00000024783 | ENSMUSP00000038263 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Nucleolar complex protein 4 homolog. | 0.999 |
Bysl | Nop14 | ENSMUSP00000024783 | ENSMUSP00000038382 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). | 0.999 |
Bysl | Nsa2 | ENSMUSP00000024783 | ENSMUSP00000073161 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). | 0.759 |
Bysl | Riok1 | ENSMUSP00000024783 | ENSMUSP00000021866 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...] | 0.904 |
Bysl | Riok2 | ENSMUSP00000024783 | ENSMUSP00000024620 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. | 0.997 |
Bysl | Riok3 | ENSMUSP00000024783 | ENSMUSP00000025270 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of [...] | 0.818 |
Bysl | Tsr1 | ENSMUSP00000024783 | ENSMUSP00000039027 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. | 0.999 |
Bysl | Wdr12 | ENSMUSP00000024783 | ENSMUSP00000027173 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.848 |
Gtpbp4 | Bysl | ENSMUSP00000152412 | ENSMUSP00000024783 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.916 |
Gtpbp4 | Ltv1 | ENSMUSP00000152412 | ENSMUSP00000019950 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Protein LTV1 homolog; Belongs to the LTV1 family. | 0.962 |
Gtpbp4 | Noc4l | ENSMUSP00000152412 | ENSMUSP00000038263 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Nucleolar complex protein 4 homolog. | 0.803 |
Gtpbp4 | Nop14 | ENSMUSP00000152412 | ENSMUSP00000038382 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). | 0.951 |
Gtpbp4 | Nsa2 | ENSMUSP00000152412 | ENSMUSP00000073161 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). | 0.999 |
Gtpbp4 | Riok1 | ENSMUSP00000152412 | ENSMUSP00000021866 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...] | 0.710 |
Gtpbp4 | Riok2 | ENSMUSP00000152412 | ENSMUSP00000024620 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. | 0.752 |
Gtpbp4 | Riok3 | ENSMUSP00000152412 | ENSMUSP00000025270 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of [...] | 0.500 |
Gtpbp4 | Tsr1 | ENSMUSP00000152412 | ENSMUSP00000039027 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. | 0.918 |
Gtpbp4 | Wdr12 | ENSMUSP00000152412 | ENSMUSP00000027173 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.996 |