8 items (mouse) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Iglc2	Ig lambda-2 chain C region. (104 aa)
	Igll1	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development. (209 aa)
	Pigr	Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity). (771 aa)
	Olfr148	Olfactory receptor 148; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa)
	Ighv6-4	Immunoglobulin heavy variable V6-4. (99 aa)
	Ighv6-5	Ig heavy chain V-III region J606. (99 aa)
	Jchain	Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. (159 aa)
	Klhl15	Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, [...] (604 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ighv6-4	Ighv6-5	ENSMUSP00000136881	ENSMUSP00000136790	Immunoglobulin heavy variable V6-4.	Ig heavy chain V-III region J606.	0.565
Ighv6-4	Iglc2	ENSMUSP00000136881	ENSMUSP00000100464	Immunoglobulin heavy variable V6-4.	Ig lambda-2 chain C region.	0.789
Ighv6-4	Igll1	ENSMUSP00000136881	ENSMUSP00000097713	Immunoglobulin heavy variable V6-4.	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.	0.789
Ighv6-4	Jchain	ENSMUSP00000136881	ENSMUSP00000084259	Immunoglobulin heavy variable V6-4.	Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.	0.815
Ighv6-4	Pigr	ENSMUSP00000136881	ENSMUSP00000027675	Immunoglobulin heavy variable V6-4.	Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).	0.568
Ighv6-5	Ighv6-4	ENSMUSP00000136790	ENSMUSP00000136881	Ig heavy chain V-III region J606.	Immunoglobulin heavy variable V6-4.	0.565
Ighv6-5	Iglc2	ENSMUSP00000136790	ENSMUSP00000100464	Ig heavy chain V-III region J606.	Ig lambda-2 chain C region.	0.792
Ighv6-5	Igll1	ENSMUSP00000136790	ENSMUSP00000097713	Ig heavy chain V-III region J606.	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.	0.938
Ighv6-5	Jchain	ENSMUSP00000136790	ENSMUSP00000084259	Ig heavy chain V-III region J606.	Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.	0.930
Ighv6-5	Pigr	ENSMUSP00000136790	ENSMUSP00000027675	Ig heavy chain V-III region J606.	Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).	0.605
Iglc2	Ighv6-4	ENSMUSP00000100464	ENSMUSP00000136881	Ig lambda-2 chain C region.	Immunoglobulin heavy variable V6-4.	0.789
Iglc2	Ighv6-5	ENSMUSP00000100464	ENSMUSP00000136790	Ig lambda-2 chain C region.	Ig heavy chain V-III region J606.	0.792
Iglc2	Igll1	ENSMUSP00000100464	ENSMUSP00000097713	Ig lambda-2 chain C region.	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.	0.805
Iglc2	Jchain	ENSMUSP00000100464	ENSMUSP00000084259	Ig lambda-2 chain C region.	Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.	0.864
Iglc2	Pigr	ENSMUSP00000100464	ENSMUSP00000027675	Ig lambda-2 chain C region.	Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).	0.610
Igll1	Ighv6-4	ENSMUSP00000097713	ENSMUSP00000136881	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.	Immunoglobulin heavy variable V6-4.	0.789
Igll1	Ighv6-5	ENSMUSP00000097713	ENSMUSP00000136790	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.	Ig heavy chain V-III region J606.	0.938
Igll1	Iglc2	ENSMUSP00000097713	ENSMUSP00000100464	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.	Ig lambda-2 chain C region.	0.805
Igll1	Jchain	ENSMUSP00000097713	ENSMUSP00000084259	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.	Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.	0.907
Igll1	Pigr	ENSMUSP00000097713	ENSMUSP00000027675	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.	Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).	0.750