(10 nodes) Alpha crystallin/Hsp20 domain network (Mus musculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Your Input:
	Hspb7	Heat shock protein beta-7. (169 aa)
	Hspb6	Heat shock protein beta-6; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. (162 aa)
	Hspb8	Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family. (196 aa)
	Cryaa	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens (By similarity). Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). (196 aa)
	Hspb9	Heat shock protein beta-9. (199 aa)
	Hspb1	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity). (209 aa)
	Cryab	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	Hspb2	Heat shock protein beta-2; May regulate the kinase DMPK; Belongs to the small heat shock protein (HSP20) family. (182 aa)
	Hspb3	Heat shock protein beta-3; Inhibitor of actin polymerization; Belongs to the small heat shock protein (HSP20) family. (154 aa)
	Odf1	Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. (248 aa)

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cryaa	Cryab	ENSMUSP00000019192	ENSMUSP00000149803	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens (By similarity). Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity).	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.993
Cryaa	Hspb7	ENSMUSP00000019192	ENSMUSP00000099544	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens (By similarity). Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity).	Heat shock protein beta-7.	0.435
Cryaa	Hspb9	ENSMUSP00000019192	ENSMUSP00000130551	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens (By similarity). Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity).	Heat shock protein beta-9.	0.527
Cryab	Cryaa	ENSMUSP00000149803	ENSMUSP00000019192	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens (By similarity). Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity).	0.993
Cryab	Hspb1	ENSMUSP00000149803	ENSMUSP00000005077	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).	0.875
Cryab	Hspb2	ENSMUSP00000149803	ENSMUSP00000042374	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-2; May regulate the kinase DMPK; Belongs to the small heat shock protein (HSP20) family.	0.842
Cryab	Hspb6	ENSMUSP00000149803	ENSMUSP00000039172	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-6; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.	0.782
Cryab	Hspb7	ENSMUSP00000149803	ENSMUSP00000099544	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-7.	0.422
Cryab	Hspb8	ENSMUSP00000149803	ENSMUSP00000037007	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family.	0.761
Cryab	Hspb9	ENSMUSP00000149803	ENSMUSP00000130551	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-9.	0.608
Hspb1	Cryab	ENSMUSP00000005077	ENSMUSP00000149803	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.875
Hspb1	Hspb6	ENSMUSP00000005077	ENSMUSP00000039172	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).	Heat shock protein beta-6; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.	0.408
Hspb1	Hspb7	ENSMUSP00000005077	ENSMUSP00000099544	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).	Heat shock protein beta-7.	0.492
Hspb1	Hspb8	ENSMUSP00000005077	ENSMUSP00000037007	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).	Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family.	0.921
Hspb1	Hspb9	ENSMUSP00000005077	ENSMUSP00000130551	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).	Heat shock protein beta-9.	0.495
Hspb2	Cryab	ENSMUSP00000042374	ENSMUSP00000149803	Heat shock protein beta-2; May regulate the kinase DMPK; Belongs to the small heat shock protein (HSP20) family.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.842
Hspb2	Hspb3	ENSMUSP00000042374	ENSMUSP00000054193	Heat shock protein beta-2; May regulate the kinase DMPK; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein beta-3; Inhibitor of actin polymerization; Belongs to the small heat shock protein (HSP20) family.	0.917
Hspb2	Hspb7	ENSMUSP00000042374	ENSMUSP00000099544	Heat shock protein beta-2; May regulate the kinase DMPK; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein beta-7.	0.867
Hspb2	Hspb8	ENSMUSP00000042374	ENSMUSP00000037007	Heat shock protein beta-2; May regulate the kinase DMPK; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family.	0.865
Hspb2	Hspb9	ENSMUSP00000042374	ENSMUSP00000130551	Heat shock protein beta-2; May regulate the kinase DMPK; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein beta-9.	0.756