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Adamts20 Adamts20 Adamts6 Adamts6 Adamts4 Adamts4 Adam9 Adam9 Adamts3 Adamts3 Adam32 Adam32 Adamts7 Adamts7 Adam34 Adam34 Adam33 Adam33 Adam8 Adam8 Adam17 Adam17 Adam1a Adam1a Adamts17 Adamts17 Adam25 Adam25 Adamts18 Adamts18 Adamts14 Adamts14 Adam22 Adam22 Adamts10 Adamts10 Adam23 Adam23 Adam4 Adam4 Adamts16 Adamts16 Adam26b Adam26b Adam1b Adam1b Gm4787 Gm4787 Adamts8 Adamts8 Adam11 Adam11 Adamts15 Adamts15 Adam39 Adam39 Adam6b Adam6b Adam12 Adam12 Adam10 Adam10 Adam30 Adam30 Adam6a Adam6a Adam34l Adam34l Adam26a Adam26a Adamts12 Adamts12 Adam20 Adam20 Adam29 Adam29 Adam5 Adam5 Adam24 Adam24 Adamts19 Adamts19 Adamts2 Adamts2 Adam3 Adam3 Adam18 Adam18 Adam15 Adam15 Adamts5 Adamts5 Adamts1 Adamts1 Adam28 Adam28 Adamdec1 Adamdec1 Adam7 Adam7 Adam2 Adam2 Adam19 Adam19 Adam21 Adam21
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Adamts20A disintegrin and metalloproteinase with thrombospondin motifs 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain. (1906 aa)
Adamts6A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6. (1117 aa)
Adamts4A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|- Ala-393' site (By similarity). (845 aa)
Adam9Disintegrin and metalloproteinase domain-containing protein 9; Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. (863 aa)
Adamts3A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. (1204 aa)
Adam32Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. (754 aa)
Adamts7A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. (1657 aa)
Adam34A disintegrin and metallopeptidase domain 34. (714 aa)
Adam33Disintegrin and metalloproteinase domain-containing protein 33. (797 aa)
Adam8Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. (826 aa)
Adam17Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of [...] (846 aa)
Adam1aDisintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion. (791 aa)
Adamts17A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17. (1122 aa)
Adam25Disintegrin and metalloproteinase domain-containing protein 25; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. (760 aa)
Adamts18A disintegrin and metalloproteinase with thrombospondin motifs 18. (1219 aa)
Adamts14A Disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 14. (1206 aa)
Adam22Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. (904 aa)
Adamts10A disintegrin and metalloproteinase with thrombospondin motifs 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues (By similarity). (1104 aa)
Adam23Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). (829 aa)
Adam4A disintegrin and metallopeptidase domain 4. (763 aa)
Adamts16A disintegrin and metalloproteinase with thrombospondin motifs 16. (1222 aa)
Adam26bA disintegrin and metallopeptidase domain 26B. (699 aa)
Adam1bDisintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. (806 aa)
Gm4787Predicted gene, EG214321. (748 aa)
Adamts8A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties. (905 aa)
Adam11Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. (778 aa)
Adamts15A disintegrin and metalloproteinase with thrombospondin motifs 15. (950 aa)
Adam39A disintegrin and metallopeptidase domain 39. (756 aa)
Adam6bA disintegrin and metallopeptidase domain 6B. (756 aa)
Adam12Disintegrin and metalloproteinase domain-containing protein 12; Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. (903 aa)
Adam10Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP) at '687-Lys-|- Leu-688' (By similarity). Contributes to the normal cleavage of the cellula [...] (749 aa)
Adam30A disintegrin and metallopeptidase domain 30. (732 aa)
Adam6aA disintegrin and metallopeptidase domain 6A. (754 aa)
Adam34lA disintegrin and metallopeptidase domain 34-like. (736 aa)
Adam26aDisintegrin and metalloproteinase domain-containing protein 26A; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. (697 aa)
Adamts12A disintegrin and metalloproteinase with thrombospondin motifs 12; Metalloprotease that plays a role in the degradation of COMP (By similarity). Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties (By similarity). (1600 aa)
Adam20A disintegrin and metallopeptidase domain 20. (760 aa)
Adam29Disintegrin and metalloproteinase domain-containing protein 29; May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein (By similarity). (763 aa)
Adam5Disintegrin and metalloproteinase domain-containing protein 5; This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). (771 aa)
Adam24Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization. (761 aa)
Adamts19A disintegrin and metalloproteinase with thrombospondin motifs 19. (1210 aa)
Adamts2A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). (1213 aa)
Adam3A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct. (822 aa)
Adam18Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein. (719 aa)
Adam15Disintegrin and metalloproteinase domain-containing protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. [...] (864 aa)
Adamts5A disintegrin and metalloproteinase with thrombospondin motifs 5; Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle de [...] (930 aa)
Adamts1A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1691- Glu-|-Leu-1692' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity (By similarity). Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture (By similarity). (968 aa)
Adam28Disintegrin and metalloproteinase domain-containing protein 28; May play a role in organogenesis and organ-specific functions such as thymic T-cell development. (793 aa)
Adamdec1ADAM DEC1; May play an important role in the control of the immune response and during pregnancy. (467 aa)
Adam7Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. (789 aa)
Adam2Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). (735 aa)
Adam19Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). (920 aa)
Adam21Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. (729 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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